Drug & supplement interaction

Horseradish + Botulinum Toxin Type A

Botulinum Toxin Type A brand name: Botox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Horseradish and Botulinum Toxin Type A in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Horseradish and Botulinum Toxin Type A

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Botulinum Toxin Type A and Horseradish in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Horseradish safety at a glance

Horseradish overall Use caution Food amounts are generally safe, but concentrated supplements may irritate the digestive tract and mucous membranes.
Pregnancy Avoid Avoid medicinal amounts during pregnancy because safety has not been established.
Breastfeeding Likely Safe When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Botulinum Toxin Type A and Horseradish? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Horseradish Does Interact With Other Medications

Horseradish has 16 moderate known drug interactions in our database — Botulinum Toxin Type A isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Botulinum Toxin Type A)
Taking anything else?

Check Another of Your Medications Against Horseradish

Covers the 2,830 medications we’ve checked against Horseradish. Pick one to open its full report.

What to actually watch for

What Horseradish Itself Has Been Linked To

This is not an interaction — nothing below involves Botulinum Toxin Type A. It is the side-effect record for Horseradish on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Horseradish, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Fainting Worth acting on Additional detail

    “Orally, consuming large amounts of horseradish can cause vasovagal syncope in rare cases. At least two cases of vasovagal syncope associated with horseradish consumption have been reported. In one case, a 56-year-old male experienced a sharp burning sensation in his stomach followed by tachycardia, weakness, and excessive perspiration after consuming an oyster topped with an olive-sized dollop of fresh horseradish.”

    Horseradish · Natural Medicines adverse-effect record, reported in irregular heartbeat.

    1 source cited
    1. 111724. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed
  • An allergic reaction Worth acting on Additional detail

    Recorded for Horseradish in the same Natural Medicines adverse-effect record shown under Fainting above.

  • Sweating / A fast or pounding heartbeat Additional detail

    Recorded for Horseradish in the same Natural Medicines adverse-effect record shown under Fainting above.

  • Stomach upset / Diarrhea / Vomiting Additional detail

    “Orally, consuming large amounts of horseradish can cause gastrointestinal upset, bloody vomiting and diarrhea (2,6), and irritation of mucous membranes (2,4).”

    Horseradish · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Everything above comes from the Natural Medicines adverse-effect record for Horseradish — expand a row for the licensed statement it rests on. We haven’t matched Botulinum Toxin Type A to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Botulinum Toxin Type A.

Special populations

Horseradish in Pregnancy & Breastfeeding

Lactation Likely Safe

When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US.

Lactation Likely Unsafe

When used orally in large amounts. The mustard oils produced by glucosinolates from horseradish are considered toxins that can be excreted through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Horseradish or Botulinum Toxin Type A

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Horseradish or Botulinum Toxin Type A, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Horseradish as Part of a Dietary Supplement Product? Check It for Interactions

We hold 245 real supplement products containing Horseradish, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Horseradish. Even though Horseradish itself has no known interaction with Botulinum Toxin Type A, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Horseradish and Botulinum Toxin Type A Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Horseradish
Top half

#395 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Botulinum Toxin Type A
Top half

#1,022 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Horseradish reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Horseradish and Botulinum Toxin Type A records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Horseradish

What is Horseradish?

  • Sinus and respiratory congestion
  • Urinary tract infections
  • Digestive support
  • Antimicrobial
  • Culinary flavoring

Horseradish is a pungent root used as a food and folk remedy, most often for sinus congestion and urinary tract complaints. Human evidence is limited, and while culinary amounts are generally well tolerated, concentrated supplements can irritate the stomach and should be used cautiously. Talk with your pharmacist or doctor before using horseradish as a medicine.

Armoracia rusticana · Brassicaceae · Root (fresh or dried) · Fresh grated root, dried root powder, prepared condiment (sauce), capsules, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Horseradish is a good idea for someone in your situation. Here is what our Horseradish record says about it on its own.

Horseradish: dosing

There is no well-established standardized medicinal dose for horseradish. Amounts used in research and traditional practice vary widely depending on the form (fresh root, dried powder, or extract).If you use a commercial supplement, follow the directions on the product label and do not exceed the recommended amount. Avoid taking large or concentrated amounts in hopes of stronger effects, since this mainly increases the risk of irritation and side effects.

From our Horseradish monograph — the full record covers uses, side effects and every documented interaction.

Read the full Horseradish monograph & all interactions
Medication

About OnabotulinumtoxinA Injection

What Is OnabotulinumtoxinA Injection Used For?

Brand name: Botox

Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older.

BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products. Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Most-Reported Side Effects for Botulinum Toxin Type A

From FAERS, the FDA’s public side-effect reporting system (12,344 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,596 reports
Drug intolerance 1,333 reports
Nausea 1,266 reports
Migraine 1,176 reports
Dizziness 1,126 reports
See full OnabotulinumtoxinA Injection drug information
Keep checking

Other Drugs & Horseradish

Browse every other medication we’ve checked against Horseradish — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
16Moderate
0Minor
2,813No known interaction
16 Moderate 2,813 No interaction
Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Horseradish against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Horseradish list.

See the full Horseradish interactions page
See every supplement checked against Botulinum Toxin Type A, ranked by severity
Evidence & sources

Horseradish References

The 6 references that drive our Horseradish monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. PubMed
  6. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Horseradish and Botulinum Toxin Type A Together: Common Questions

Is it safe to take Horseradish with Botulinum Toxin Type A?
We do not list a known interaction between Horseradish and Botulinum Toxin Type A. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Horseradish interact with any other medications?
Yes. Horseradish has 16 documented drug interactions in our database — Botulinum Toxin Type A is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Horseradish monograph Uses, safety profile, and every drug interaction in one place OnabotulinumtoxinA Injection drug information The full plain-English guide to this medication Botulinum Toxin Type A supplement interactions Every supplement checked against Botulinum Toxin Type A, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Botulinum Toxin Type A and Horseradish?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.