Drug & supplement interaction

Hyland's Restless Legs + Levorphanol

Levorphanol brand name: Levo-Dromoran.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Hyland's Restless Legs and Levorphanol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Hyland's Restless Legs and Levorphanol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levorphanol and Hyland's Restless Legs in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hyland's Restless Legs at all — not against Levorphanol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hyland's Restless Legs safety at a glance

Hyland's Restless... overall Use caution Generally low risk because ingredients are highly diluted, but it is not proven to work and is not a substitute for medical evaluation.

Pregnancy Use caution Safety is not well established, so avoid use unless your doctor or pharmacist approves.

Breastfeeding Use caution Safety while breastfeeding is not well established, so check with your doctor or pharmacist first.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

In most situations, clinically significant interactions between homeopathic products and prescription or over-the-counter medications are extremely unlikely.

Homeopathic medications, which utilize the principle of 'like cures like', are often highly diluted substances. These dilutions are typically so high that the final remedy contains only a tiny amount of the original active ingredient, if any at all.

In theory, because the concentration of the active ingredient is so low, homeopathic preparations are unlikely to interact with other medications in the body.

This is certainly the case with Hyland's Restful Legs, with all the ingredients diluted at potencies of 6X or 12X. A potency of 6X means that the original substance has been diluted by a factor of 10^6, or one part in a million (i.e., for every million parts of the solution, there is one part of the original substance).

It is important to note that not all homeopathic remedies are free of potential drug interactions as some use very low dilutions (which is often the case with zinc-containing products).

Nevertheless, there are no known drug interactions between Hyland's Restful Legs and other medications. It is also thought to be safe to take along with medications to help sleep, like Benadryl, melatonin, and NyQuil, which are commonly used with the product to help sleep.

— Dr. Brian Staiger, PharmD, BCPS

Still wondering about combining Levorphanol and Hyland's Restless Legs? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Levorphanol’s Own FDA Label Lists

This is not an interaction — none of it involves Hyland's Restless Legs. These are the most notable effects listed in the ADVERSE REACTIONS section of Levorphanol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Dependence or withdrawal symptoms Worth acting on
Serotonin syndrome Worth acting on
Thoughts of self-harm Worth acting on
Memory problems Worth acting on
Trouble passing urine Worth acting on
Low blood sugar Worth acting on
A slow heartbeat Worth acting on
Confusion Worth acting on
Seizures Worth acting on
Low mood Worth acting on

Showing the 10 most notable of 30 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Levorphanol. Read the label on DailyMed › Hyland's Restless Legs’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Hyland's Restless Legs side to compare — that is a limit of the record, not a statement that Hyland's Restless Legs has no side effects.

Everything else you take

See Every Supplement That Interacts With Levorphanol

This page covers Hyland's Restless Legs only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levorphanol page lists 100 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 78 moderate · 15 minor.

From our pharmacist’s overview on the Levorphanol page

“Most of the ingredients that interact with levorphanol (Levo-Dromoran) pile onto the same hazard, deeper sedation. Because levorphanol is a potent opioid painkiller, that stacking can slow breathing rather than just cause drowsiness, so this page deserves real vigilance before you add a supplement to it.”

Reviewed by 2 · Jul 18, 2026

Open the Levorphanol interaction page

How much people look this up

Where Hyland's Restless Legs and Levorphanol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hyland's Restless Legs

Steady interest

#1,308 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Levorphanol

Top 10%

#208 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Hyland's Restless Legs is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hyland's Restless Legs reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hyland's Restless Legs and Levorphanol records this page draws on were last updated June 20, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Hyland's Restless Legs

What is Hyland's Restless Legs?

Restless legs sensations
Urge to move the legs
Leg twitching or jerking
Crawling or itching feelings in the legs
Trouble resting due to leg discomfort

Hyland's Restful Legs (often called 'Restless Legs') is a homeopathic product marketed to calm agitated legs so you can rest. Its ingredients are extremely diluted, and there is no strong scientific evidence that it relieves restless legs syndrome. If you have ongoing leg symptoms, talk with a pharmacist or doctor, since restless legs can have treatable underlying causes such as low iron.

Highly diluted homeopathic ingredients (not a single plant part) · Quick-dissolving tablets (daytime and nighttime/PM versions)

An interaction check asks whether these two react with each other — it does not ask whether Hyland's Restless Legs is a good idea for someone in your situation. Here is what our Hyland's Restless Legs record says about it on its own.

Hyland's Restless Legs: dosing

There is no scientifically established dose for this product, since it has not been proven effective in clinical trials. Always follow the directions on the package label. Do not exceed the labeled amount, and do not use it as a substitute for treatments your doctor has recommended.

From our Hyland's Restless Legs monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hyland's Restless Legs monograph & all interactions

Medication

About Levorphanol

What Is Levorphanol Used For?

Brand name: Levo-Dromoran

Levorphanol Tartrate Tablets are used to manage pain severe enough to require an opioid — specifically when non-opioid or other pain treatments haven't provided enough relief or aren't a good fit for the patient.

It is not meant for everyday or mild pain. Prescribers weigh the serious risks of opioid therapy carefully before choosing this medication, and it should be used for only as long as the pain requires it.

See full Levorphanol drug information

Keep checking

Other Drugs & Hyland's Restless Legs

Browse every other medication we’ve checked against Hyland's Restless Legs — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Hyland's Restless Legs against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hyland's Restless Legs list.

See the full Hyland's Restless Legs interactions page

See every supplement checked against Levorphanol, ranked by severity

Evidence & sources

Hyland's Restless Legs References

The 3 sources that drive our Hyland's Restless Legs monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Hyland's Restless Legs is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Homeopathy — NIH NCCIH Source
Restless Legs Syndrome — MedlinePlus Source
Homeopathic Products — U.S. Food and Drug Administration Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hyland's Restless Legs and Levorphanol Together: Common Questions

Is it safe to take Hyland's Restless Legs with Levorphanol?

We do not list a known interaction between Hyland's Restless Legs and Levorphanol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Levorphanol interact with any supplements?

Yes. Levorphanol has documented interactions with 100 supplements in our database — Hyland's Restless Legs is not one of them. The Levorphanol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hyland's Restless Legs monograph Uses, safety profile, and every drug interaction in one place Levorphanol drug information The full plain-English guide to this medication Levorphanol supplement interactions Every supplement checked against Levorphanol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levorphanol and Hyland's Restless Legs?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.