Drug & supplement interaction

Immortelle + Imiquimod

Imiquimod brand names: Aldara, Zyclara, Vyloma.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Immortelle and Imiquimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Immortelle and Imiquimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Imiquimod and Immortelle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Immortelle at all — not against Imiquimod, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Immortelle safety at a glance

Immortelle overall Use caution Generally used in food and tea amounts, but human safety data for supplements is limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid unless cleared by your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Imiquimod and Immortelle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Imiquimod’s Own FDA Label Lists

This is not an interaction — none of it involves Immortelle. These are the most notable effects listed in the ADVERSE REACTIONS section of Imiquimod’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on
  • Back pain
  • Fever
  • Itching
  • Swelling
  • Tiredness
  • Dizziness
  • Diarrhea
  • Headache

From the ADVERSE REACTIONS section of the FDA label for Imiquimod. Read the label on DailyMed › Immortelle’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Immortelle side to compare — that is a limit of the record, not a statement that Immortelle has no side effects.

Everything else you take

See Every Supplement That Interacts With Imiquimod

This page covers Immortelle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Imiquimod page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Imiquimod page

“Imiquimod (Aldara, Zyclara, Vyloma) is a cream for warts, precancerous spots, and certain skin cancers, and its supplement list is short and workable for most people. Only 3 ingredients are on file, none rated major, and all involve products applied to the skin rather than swallowed.”

Reviewed by 2 · Jul 18, 2026

Open the Imiquimod interaction page

One more smart check

Taking Immortelle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Immortelle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Immortelle. Even though Immortelle itself has no known interaction with Imiquimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Immortelle and Imiquimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Immortelle
Steady interest

#1,195 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Imiquimod
Steady interest

#1,576 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Immortelle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Immortelle and Imiquimod records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Immortelle

What is Immortelle?

  • Digestive and liver support
  • Skin health and wound care
  • Mild inflammation
  • Antioxidant support
  • Cough and respiratory complaints

Immortelle (Helichrysum) is a Mediterranean flowering herb used traditionally for digestion, skin, and mild inflammation. Human evidence for these uses is very limited, so it should be seen as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Helichrysum arenarium · Asteraceae · Flowers (flower heads) and essential oil · Tea, dried flowers, tincture, capsules, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Immortelle is a good idea for someone in your situation. Here is what our Immortelle record says about it on its own.

Immortelle: dosing

There is no official, standardized dose of immortelle. Traditional use involves brewing the dried flowers as a tea or using a tincture, but the amount of active compounds can vary a lot between products.If you use a commercial supplement, follow the directions on the product label and do not exceed them. Essential oil is for external or aromatherapy use only and must be diluted.

From our Immortelle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Immortelle monograph & all interactions
Medication

About Imiquimod Topical

What Is Imiquimod Topical Used For?

Brand names: Aldara, Zyclara, Vyloma

Imiquimod cream is used to treat three skin conditions in adults: actinic keratoses (rough, scaly patches on the skin caused by sun damage) on the face or scalp; superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, or limbs when surgery is not the best option; and external genital and perianal warts (condyloma acuminata) in patients 12 years and older.

It is not effective for molluscum contagiosum in children ages 2–12, and it has not been proven safe or effective in people with weakened immune systems. It should not be used for warts inside the urethra, vagina, cervix, rectum, or anal canal.

Most-Reported Side Effects for Imiquimod

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Erythema 183 reports
Fatigue 179 reports
Nausea 114 reports
Influenza like illness 102 reports
Application site erythema 100 reports
See full Imiquimod Topical drug information
Keep checking

Other Drugs & Immortelle

Browse every other medication we’ve checked against Immortelle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Immortelle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Immortelle list.

See the full Immortelle interactions page
See every supplement checked against Imiquimod, ranked by severity
Evidence & sources

Immortelle References

The 1 references that drive our Immortelle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Immortelle and Imiquimod Together: Common Questions

Is it safe to take Immortelle with Imiquimod?
We do not list a known interaction between Immortelle and Imiquimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Imiquimod interact with any supplements?
Yes. Imiquimod has documented interactions with 3 supplements in our database — Immortelle is not one of them. The Imiquimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Immortelle monograph Uses, safety profile, and every drug interaction in one place Imiquimod Topical drug information The full plain-English guide to this medication Imiquimod supplement interactions Every supplement checked against Imiquimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Imiquimod and Immortelle?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.