Drug & supplement interaction

Indian Gooseberry + Metaxalone

Metaxalone brand name: Skelaxin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Indian Gooseberry and Metaxalone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Indian Gooseberry and Metaxalone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metaxalone and Indian Gooseberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indian Gooseberry safety at a glance

Indian Gooseberry overall Use caution Generally well tolerated as a food, but supplement safety is less studied.
Pregnancy Avoid Not enough safety data for supplement doses, so it is best to avoid.
Breastfeeding Avoid There is too little reliable safety information during breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metaxalone and Indian Gooseberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metaxalone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metaxalone is filed under 2 classifications — skeletal muscle relaxants, oral drugs. Indian Gooseberry has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and aspirin (moderate) — and none of Metaxalone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indian Gooseberry Does Interact With Other Medications

Indian Gooseberry has 208 moderate known drug interactions in our database — Metaxalone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Metaxalone)
Taking anything else?

Check Another of Your Medications Against Indian Gooseberry

Covers the 2,830 medications we’ve checked against Indian Gooseberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Indian Gooseberry and Metaxalone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Indian Gooseberry

    “Orally, epigastric discomfort or dyspepsia have been reported by up to four individuals in clinical trials.”

    Indian Gooseberry · Natural Medicines adverse-effect record, reported in dyspepsia.

    2 sources cited
    1. 105354. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
    2. 105356. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed

    Metaxalone

    Listed in the ADVERSE REACTIONS section of the FDA label for Metaxalone. Read the label on DailyMed ›

  • Itching Additional detail

    Indian Gooseberry

    “Orally, itching has been reported by one individual in a clinical trial.”

    Indian Gooseberry · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 105354. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro

    Metaxalone

    Listed in the ADVERSE REACTIONS section of the FDA label for Metaxalone. Read the label on DailyMed ›

Reported for Indian Gooseberry but not commonly for Metaxalone: muscle pain and tiredness.

Effects for Metaxalone come from the ADVERSE REACTIONS section of its FDA label; effects for Indian Gooseberry come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,328 voluntary FDA FAERS reports for Metaxalone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Indian Gooseberry or Metaxalone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Indian Gooseberry or Metaxalone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metaxalone

This page covers Indian Gooseberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metaxalone page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Metaxalone page

“Most of what interacts with metaxalone (Skelaxin), a muscle relaxant prescribed for painful muscle spasms, works by getting between the pill and your bloodstream. Fiber gums, mucilage herbs like slippery elm, and above all activated charcoal can bind or slow the drug in the gut, leaving you with less relief than your dose should deliver.”

Reviewed by 2 · Jul 18, 2026

Open the Metaxalone interaction page

One more smart check

Taking Indian Gooseberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,248 real supplement products containing Indian Gooseberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indian Gooseberry. Even though Indian Gooseberry itself has no known interaction with Metaxalone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indian Gooseberry and Metaxalone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indian Gooseberry
Top 10%

#106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metaxalone
Steady interest

#1,838 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indian Gooseberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Indian Gooseberry and Metaxalone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indian Gooseberry

What is Indian Gooseberry?

Indian Gooseberry
  • Antioxidant support
  • Cholesterol and heart health
  • Immune support
  • Digestive health
  • Skin and hair care

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some uses like cholesterol, but most claims are not yet proven by strong human studies. It is generally well tolerated as a food, but talk to your pharmacist or doctor before taking concentrated supplements.

Phyllanthus emblica · Phyllanthaceae · Fruit (sometimes seeds, leaves, and bark) · Capsules, tablets, powder, juice, dried fruit, and extracts

An interaction check asks whether these two react with each other — it does not ask whether Indian Gooseberry is a good idea for someone in your situation. Here is what our Indian Gooseberry record says about it on its own.

Indian Gooseberry: dosing

There is no official, standardized dose of Indian gooseberry. The right amount depends on the product, whether it is a juice, powder, or extract, and how concentrated it is.Because doses vary so much between products, the safest approach is to follow the directions on the product label. They can help you decide whether it is appropriate for you.

From our Indian Gooseberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indian Gooseberry monograph & all interactions
Medication

About Metaxalone

What Is Metaxalone Used For?

Brand name: Skelaxin

Metaxalone tablets are used to help relieve discomfort caused by acute (short-term), painful musculoskeletal conditions — things like muscle strains, sprains, and similar injuries. It is meant to be used together with rest, physical therapy, and other treatments, not as a stand-alone fix.

This use applies to adults and adolescents 13 years of age and older. Metaxalone tablets are available as the branded product Skelaxin and as a generic.

Most-Reported Side Effects for Metaxalone

From FAERS, the FDA’s public side-effect reporting system (3,328 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Completed suicide 261 reports
Nausea 198 reports
Fatigue 196 reports
Headache 172 reports
Toxicity to various agents 164 reports
See full Metaxalone drug information
Keep checking

Other Drugs & Indian Gooseberry

Browse every other medication we’ve checked against Indian Gooseberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Indian Gooseberry page.

No interaction 2,621 drugs checked — show the list

We also checked Indian Gooseberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full Indian Gooseberry list.

See the full Indian Gooseberry interactions page
See every supplement checked against Metaxalone, ranked by severity
Evidence & sources

Indian Gooseberry References

The 6 references that drive our Indian Gooseberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indian Gooseberry and Metaxalone Together: Common Questions

Is it safe to take Indian Gooseberry with Metaxalone?
We do not list a known interaction between Indian Gooseberry and Metaxalone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Indian Gooseberry and Metaxalone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Indian Gooseberry and Metaxalone combination checked?
Interactions in our licensed database are recorded against drug classes. Metaxalone is filed under 2 classifications, and Indian Gooseberry has documented interactions with 4 drug classes — none of Metaxalone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Indian Gooseberry interact with any other medications?
Yes. Indian Gooseberry has 208 documented drug interactions in our database — Metaxalone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metaxalone interact with any supplements?
Yes. Metaxalone has documented interactions with 20 supplements in our database — Indian Gooseberry is not one of them. The Metaxalone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indian Gooseberry monograph Uses, safety profile, and every drug interaction in one place Metaxalone drug information The full plain-English guide to this medication Metaxalone supplement interactions Every supplement checked against Metaxalone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metaxalone and Indian Gooseberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.