Drug & supplement interaction

K2/spice + Desflurane

Desflurane brand name: Suprane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between K2/spice and Desflurane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

K2/spice and Desflurane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Desflurane and K2/spice in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

K2/spice safety at a glance

K2/spice overall Avoid These products are illegal, unregulated, and have caused serious harm and death.
Pregnancy Avoid Never use during pregnancy; it can seriously harm both mother and baby.
Breastfeeding Avoid Avoid while breastfeeding; chemicals can pass to the infant and cause harm.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Desflurane and K2/spice? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Desflurane

Interactions in our licensed database are recorded against drug classes, not just single drug names. Desflurane is filed under 2 classifications — anesthesia, oral drugs. K2/spice has documented interactions with 2 drug classes — the most serious being anticonvulsants (moderate) and qt interval-prolonging drugs (moderate) — and none of Desflurane’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

K2/spice Does Interact With Other Medications

K2/spice has 208 moderate known drug interactions in our database — Desflurane isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 No known interaction 2,622 (incl. Desflurane)
Taking anything else?

Check Another of Your Medications Against K2/spice

Covers the 2,830 medications we’ve checked against K2/spice. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests K2/spice and Desflurane May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 10 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice has been associated with rhabdomyolysis. In one case series, 8 of 30 patients requiring critical care for K2/spice use experienced rhabdomyolysis. Also, a 23-year-old male who smoked K2/spice daily for two weeks presented to the emergency department with psychosis, severe agitation, and highly elevated creatine phosphokinase (CPK) levels.”

    K2/spice · Natural Medicines adverse-effect record, reported in muscle breakdown.

    2 sources cited
    1. 98848. Durand D, Delgado LL, de la Parra-Pellot DM, Nichols-Vinueza D. Psychosis and severe rhabdomyolysis associated with synthetic cannabinoid use: a case report. Clin Schizophr Relat Psychoses 2015;8(4):205-8. DOI
    2. 103080. Kourouni I, Mourad B, Khouli H, Shapiro JM, Mathew JP. Critical Illness Secondary to Synthetic Cannabinoid Ingestion. JAMA Netw Open. 2020;3(7):e208516. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • A slow heartbeat / An irregular heartbeat / Raised blood pressure Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice can cause serious adverse cardiovascular effects, including tachycardia or bradycardia, hypertension or hypotension, coronary vasospasm, acute coronary syndrome, congestive heart failure, ventricular fibrillation, QT prolongation, myocardial ischemia/infarction, stroke, cardiac arrest, cardiomyopathy, and sudden cardiac death.”

    K2/spice · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 98843. Andonian DO, Seaman SR, Josephson EB. Profound hypotension and bradycardia in the setting of synthetic cannabinoid intoxication - a case series. Am J Emerg Med 2017;35(6):940.e5-940.e6. PubMed
    2. 98844. McIlroy G, Ford L, Khan JM. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacol Toxicol 2016;17:2. PubMed
    3. 98846. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
    4. 98849. Freeman MJ, Rose DZ, Myers MA, Gooch CL, Bozeman AC, Burgin WS. Ischemic stroke after use of the synthetic marijuana "spice". Neurology 2013;81(24):2090-3. PubMed
    5. 99617. Law R, Schier J, Martin C, Chang A, Wolkin A; Centers for Disease Control (CDC). Notes from the field: increase in reported adverse health effects related to synthetic cannabinoid use - United States, January-May 2015. MMWR Morb Mortal Wkly Rep 2015;64(22
    6. 99619. Monte AA, Calello DP, Gerona RR, et al. Characteristics and treatment of patients with clinical illness due to synthetic cannabinoid inhalation reported by medical toxicologists: a ToxIC database study. J Med Toxicol 2017;13(2):146-52. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • A heart attack Worth acting on Additional detail

    K2/spice

    Recorded for K2/spice in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice can cause drowsiness, lethargy, vertigo, ataxia, hyperreflexia, nystagmus, confusion, anxiety, cognitive impairment, emotional dysregulation, seizures, and coma. Numerous cases of seizures secondary to K2/spice use have been reported.”

    K2/spice · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 99616. Lamy FR, Daniulaityte R, Nahhas RW, et al. Increases in synthetic cannabinoids-related harms: results from a longitudinal web-based content analysis. Int J Drug Policy. 2017;44:121-9. PubMed
    2. 99617. Law R, Schier J, Martin C, Chang A, Wolkin A; Centers for Disease Control (CDC). Notes from the field: increase in reported adverse health effects related to synthetic cannabinoid use - United States, January-May 2015. MMWR Morb Mortal Wkly Rep 2015;64(22
    3. 99619. Monte AA, Calello DP, Gerona RR, et al. Characteristics and treatment of patients with clinical illness due to synthetic cannabinoid inhalation reported by medical toxicologists: a ToxIC database study. J Med Toxicol 2017;13(2):146-52. PubMed
    4. 99621. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR. A common source outbreak of severe delirium associated with exposure to the novel synthetic cannabinoid ADB-PINACA. J Emerg Med 2015;48(5):573-80. PubMed
    5. 99624. Tait RJ, Caldicott D, Mountain D, Hill SL, Lenton S. A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol (Phila) 2016;54(1):1-13. PubMed
    6. 103080. Kourouni I, Mourad B, Khouli H, Shapiro JM, Mathew JP. Critical Illness Secondary to Synthetic Cannabinoid Ingestion. JAMA Netw Open. 2020;3(7):e208516. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Kidney problems Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice can cause acute kidney injury. More than 50 cases requiring hospitalization have been reported in patients who smoked K2/spice.”

    K2/spice · Natural Medicines adverse-effect record, reported in acute kidney injury (aki).

    3 sources cited
    1. 98847. Davidson C, Opacka-Juffry J, Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E, Molina-Holgado F. Spicing up pharmacology: a review of synthetic cannabinoids from structure to adverse events. Adv Pharmacol 2017;80:135-68. PubMed
    2. 99624. Tait RJ, Caldicott D, Mountain D, Hill SL, Lenton S. A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol (Phila) 2016;54(1):1-13. PubMed
    3. 111236. D'Errico S, Zanon M, Radaelli D, et al. Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers. Biomedicines 2022;10(8):1936. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Shortness of breath Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice has been associated with dyspnea, dysregulated breathing, pulmonary infiltrates, respiratory failure, pneumothorax, and acute respiratory distress syndrome. Long-term use of K2/spice has been associated with chronic cough.

    In one case series, 21 of 30 patients requiring critical care for K2/spice use also required mechanical ventilation.”

    K2/spice · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    6 sources cited
    1. 98845. Chinnadurai T, Shrestha S, Ayinla R. A curious case of inhalation fever caused by synthetic cannabinoid. Am J Case Rep 2016;17:379-83. PubMed
    2. 98847. Davidson C, Opacka-Juffry J, Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E, Molina-Holgado F. Spicing up pharmacology: a review of synthetic cannabinoids from structure to adverse events. Adv Pharmacol 2017;80:135-68. PubMed
    3. 99629. Yamanoglu A, Cakmak S, Celebi Yamanoglu NG, Sogut O. A new side effect of synthetic cannabinoid use by the bucket (waterpipe) method: acute respiratory distress syndrome (ARDS). Turk J Emerg Med 2017;18(1):42-4. PubMed
    4. 103080. Kourouni I, Mourad B, Khouli H, Shapiro JM, Mathew JP. Critical Illness Secondary to Synthetic Cannabinoid Ingestion. JAMA Netw Open. 2020;3(7):e208516. PubMed
    5. 108487. Ruiz-Maldonado TM, Dorey A, Christensen ED, Campbell KA. Near-fatal spice intoxication of a toddler. Pediatrics. 2021 Aug;148(2):e2021050888. PubMed
    6. 111236. D'Errico S, Zanon M, Radaelli D, et al. Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers. Biomedicines 2022;10(8):1936. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    K2/spice

    “When inhaled, K2/spice has been associated with hepatitis. In one case, a 45-year-old male presenting with somnolence, lethargy, and fatigue after smoking 2 grams of K2/spice daily for one week was found to have evidence of hepatocellular necrosis and worsening liver failure. The patient was treated with N-acetylcysteine and made a full recovery.”

    K2/spice · Natural Medicines adverse-effect record, reported in fatigue.

    2 sources cited
    1. 99622. Sheikh IA, Luksic M, Ferstenberg R, Culpepper-Morgan JA. Spice/K2 synthetic marijuana-induced toxic hepatitis treated with N-acetylcysteine. Am J Case Rep 2014;15:584-8. PubMed
    2. 104896. Ahmed ST, Alam A, Hassan A, Kamal S, Mahmood M. Acute Liver Failure Caused by Synthetic Marijuana Use. Am J Ther. 2020. doi: 10.1097/MJT.0000000000001181. PubMed

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Bleeding or bruising Worth acting on Additional detail

    K2/spice

    “When inhaled long-term, K2/spice has been associated with immune thrombocytopenia. In one case, a 23-year-old male with a one-year history of K2/spice abuse presented with epistaxis and petechial rashes on both legs. Laboratory testing confirmed a diagnosis of immune thrombocytopenia, and the patient was successfully treated with prednisolone.”

    K2/spice · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    1 source cited
    1. 99620. Öztürk E, Oral A, Özdemir M, Bambul N. Synthetic marijuana "K2" induced ITP. Platelets 2015;26(3):258-9. PubMed

    “When inhaled, K2/spice has been linked to hematologic complications. An outbreak of synthetic cannabinoid-associated coagulopathy was reported in Illinois in 2018. Anticoagulant testing in 15 patients with suspected synthetic cannabinoid-associated coagulopathy suggested that K2/spice contaminated with brodifacoum, a 4-hydroxycoumarin derivative was to blame.”

    K2/spice · Natural Medicines adverse-effect record, reported in thrombocytopenia.

    5 sources cited
    1. 98850. Kelkar AH, Smith NA, Martial A, Moole H, Tarantino MD, Roberts JC. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med 2018;379(13):1216-23. PubMed
    2. 99620. Öztürk E, Oral A, Özdemir M, Bambul N. Synthetic marijuana "K2" induced ITP. Platelets 2015;26(3):258-9. PubMed
    3. 99626. Zheng CY, Minniti CP, Chaitowitz MH. Sickle cell crisis complicated by synthetic cannabinoid abuse: a case report. Hemoglobin 2016;40(3):220-2. PubMed
    4. 111236. D'Errico S, Zanon M, Radaelli D, et al. Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers. Biomedicines 2022;10(8):1936. PubMed
    5. 104901. Godwin PO, Unterman S, Elfessi ZZ, Bhagat JD, Kolman K. Management of Rodenticide Poisoning Associated with Synthetic Cannabinoids. Fed Pract. 2019;36(5):237-241.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

Showing the 10 most notable of 19 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for K2/spice but not commonly for Desflurane: heart failure, confusion, memory problems and dependence or withdrawal symptoms.

Effects for Desflurane come from the ADVERSE REACTIONS section of its FDA label; effects for K2/spice come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Desflurane

This page covers K2/spice only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desflurane page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Fever Bark (major), Cannabis (moderate), Coffee Charcoal (moderate) and Cowhage (moderate).

By severity: 2 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Desflurane page

“The interaction to understand first is fever bark with desflurane, the inhaled anesthetic that keeps patients asleep during surgery. Fever bark contains reserpine, tied to unstable heart function and blood pressure under general anesthesia, and it carries one of two major ratings among the 22 supplements on file.”

Reviewed by 2 · Jul 18, 2026

Open the Desflurane interaction page

How much people look this up

Where K2/spice and Desflurane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement K2/spice
Steady interest

#814 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Desflurane
Steady interest

#2,259 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every K2/spice reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The K2/spice and Desflurane records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About K2/spice

What is K2/spice?

  • Recreational drug ('legal high')
  • Marijuana substitute
  • Mood or perception changes
  • Sometimes used to avoid drug testing

K2/Spice is NOT a herbal supplement — it is plant material sprayed with man-made synthetic cannabinoid chemicals. It is dangerous, unpredictable, and has caused seizures, heart problems, psychosis, and deaths, so it should not be used.

Not a plant part; synthetic chemicals sprayed onto dried plant material · Dried plant material that is smoked or vaped; sometimes sold as liquid for vaping

An interaction check asks whether these two react with each other — it does not ask whether K2/spice is a good idea for someone in your situation. Here is what our K2/spice record says about it on its own.

K2/spice: dosing

There is no safe or recommended dose of K2/Spice. Because these are unregulated, illegal products with unknown and constantly changing ingredients, no dose can be considered safe. The strength can vary wildly even within a single package.This is not a supplement that should be taken at any amount. If you are looking for help with substance use, please reach out to a healthcare provider, pharmacist, or a substance-use support service.

From our K2/spice monograph — the full record covers uses, side effects and every documented interaction.

Read the full K2/spice monograph & all interactions
Medication

About Desflurane

What Is Desflurane Used For?

Brand name: Suprane

Desflurane (available as Desflurane USP and Suprane) is a general anesthetic given by inhalation during surgery. In adults, it is approved both to start (induce) anesthesia and to keep it going (maintain) throughout inpatient and outpatient procedures.

In infants and children, desflurane is approved only for maintaining anesthesia — and only after anesthesia has first been started with a different agent and the child has been intubated (a breathing tube placed). It is not approved to start anesthesia in children, and it must not be used to maintain anesthesia in children who are not intubated.

See full Desflurane drug information
Keep checking

Other Drugs & K2/spice

Browse every other medication we’ve checked against K2/spice — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
0Minor
2,621No known interaction
208 Moderate 2,621 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the K2/spice page.

No interaction 2,621 drugs checked — show the list

We also checked K2/spice against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,621 medications checked with no known interaction — see the full K2/spice list.

See the full K2/spice interactions page
See every supplement checked against Desflurane, ranked by severity
Evidence & sources

K2/spice References

The 40 references that drive our K2/spice monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Amar JY, Ruta J, Rahimian D, Dillinger RL, Katz P. Toxic leukoencephalopathy with extrapyramidal dysfunction due to synthetic cannabinoids. J Clin Neurosci 2018;58:213-4. PubMed
  2. Andonian DO, Seaman SR, Josephson EB. Profound hypotension and bradycardia in the setting of synthetic cannabinoid intoxication - a case series. Am J Emerg Med 2017;35(6):940.e5-940.e6. PubMed
  3. McIlroy G, Ford L, Khan JM. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacol Toxicol 2016;17:2. PubMed
  4. Chinnadurai T, Shrestha S, Ayinla R. A curious case of inhalation fever caused by synthetic cannabinoid. Am J Case Rep 2016;17:379-83. PubMed
  5. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  6. Davidson C, Opacka-Juffry J, Arevalo-Martin A, Garcia-Ovejero D, Molina-Holgado E, Molina-Holgado F. Spicing up pharmacology: a review of synthetic cannabinoids from structure to adverse events. Adv Pharmacol 2017;80:135-68. PubMed
  7. Durand D, Delgado LL, de la Parra-Pellot DM, Nichols-Vinueza D. Psychosis and severe rhabdomyolysis associated with synthetic cannabinoid use: a case report. Clin Schizophr Relat Psychoses 2015;8(4):205-8. DOI
  8. Freeman MJ, Rose DZ, Myers MA, Gooch CL, Bozeman AC, Burgin WS. Ischemic stroke after use of the synthetic marijuana "spice". Neurology 2013;81(24):2090-3. PubMed
  9. Kelkar AH, Smith NA, Martial A, Moole H, Tarantino MD, Roberts JC. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med 2018;379(13):1216-23. PubMed
  10. Lamy FR, Daniulaityte R, Nahhas RW, et al. Increases in synthetic cannabinoids-related harms: results from a longitudinal web-based content analysis. Int J Drug Policy. 2017;44:121-9. PubMed
  11. Law R, Schier J, Martin C, Chang A, Wolkin A; Centers for Disease Control (CDC). Notes from the field: increase in reported adverse health effects related to synthetic cannabinoid use - United States, January-May 2015. MMWR Morb Mortal Wkly Rep 2015;64(22
  12. Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA. Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 2014;144:12-41. PubMed
  13. Monte AA, Calello DP, Gerona RR, et al. Characteristics and treatment of patients with clinical illness due to synthetic cannabinoid inhalation reported by medical toxicologists: a ToxIC database study. J Med Toxicol 2017;13(2):146-52. PubMed
  14. Öztürk E, Oral A, Özdemir M, Bambul N. Synthetic marijuana "K2" induced ITP. Platelets 2015;26(3):258-9. PubMed
  15. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR. A common source outbreak of severe delirium associated with exposure to the novel synthetic cannabinoid ADB-PINACA. J Emerg Med 2015;48(5):573-80. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking K2/spice and Desflurane Together: Common Questions

Is it safe to take K2/spice with Desflurane?
We do not list a known interaction between K2/spice and Desflurane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do K2/spice and Desflurane have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the K2/spice and Desflurane combination checked?
Interactions in our licensed database are recorded against drug classes. Desflurane is filed under 2 classifications, and K2/spice has documented interactions with 2 drug classes — none of Desflurane's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does K2/spice interact with any other medications?
Yes. K2/spice has 208 documented drug interactions in our database — Desflurane is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Desflurane interact with any supplements?
Yes. Desflurane has documented interactions with 22 supplements in our database — K2/spice is not one of them. The Desflurane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

K2/spice monograph Uses, safety profile, and every drug interaction in one place Desflurane drug information The full plain-English guide to this medication Desflurane supplement interactions Every supplement checked against Desflurane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 40 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Desflurane and K2/spice?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.