Kamala + Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.
We found no known interaction between Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Diphenhydramine Hydrochloride, Naproxen Sodium states a food rule worth keeping to.
Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Diphenhydramine Hydrochloride, Naproxen Sodium and Kamala in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Kamala at all — not against Diphenhydramine Hydrochloride, Naproxen Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Kamala safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Diphenhydramine Hydrochloride, Naproxen Sodium Products Have a Food Rule — Kamala Should Not Break It
At least one FDA label for a product containing Diphenhydramine Hydrochloride, Naproxen Sodium says to take it with food. If you take Kamala on an empty stomach out of habit, keep them separate — and take Diphenhydramine Hydrochloride, Naproxen Sodium with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Diphenhydramine Hydrochloride, Naproxen Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Directions • do not take more than directed • drink a full glass of water with each dose • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours • if taken with food, this product may take longer to work
From the Dosage and Administration section of the FDA label we read for Diphenhydramine Hydrochloride, Naproxen Sodium — where that label names a specific product, the instruction is that product's.
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium
This page covers Kamala only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 13 major · 320 moderate · 45 minor.
From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page
“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”
Reviewed by 2 · Jul 18, 2026
Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page
Taking Kamala as Part of a Dietary Supplement Product? Check It for Interactions
We hold 6 real supplement products containing Kamala, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kamala. Even though Kamala itself has no known interaction with Diphenhydramine Hydrochloride, Naproxen Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,036 of 1,452 supplements looked up here in the last 7 days
#71 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Kamala
What is Kamala?
- Intestinal worms (especially tapeworm)
- Skin conditions and parasites
- Constipation/laxative effect
- Wound care (traditional)
- Use as a natural orange-red dye
Kamala is a red powder from the fruit of the Mallotus philippensis tree, used in traditional medicine mainly to expel intestinal worms and as a dye. Modern human evidence for its safety and effectiveness is very limited, and it can cause significant digestive upset, so it should only be used under professional guidance, if at all.
Mallotus philippensis · Euphorbiaceae · Red powder (glands and hairs) from the surface of the fruit; sometimes bark and leaves · Powder, capsules, traditional preparations; also used historically as a dye
An interaction check asks whether these two react with each other — it does not ask whether Kamala is a good idea for someone in your situation. Here is what our Kamala record says about it on its own.
Kamala: dosing
There is no well-established, standardized dose of Kamala supported by modern clinical research. Do not exceed the recommended amount, and avoid using it for self-treatment of worm infections without medical guidance, since safer and better-studied options are available.
From our Kamala monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Kamala
Browse every other medication we’ve checked against Kamala — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Kamala against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Sertraline ›
- Rosuvastatin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Clopidogrel ›
- Escitalopram ›
- Atorvastatin ›
- Rivaroxaban ›
- Warfarin Sodium ›
- Tirzepatide ›
- Isotretinoin ›
- Ibuprofen ›
- Levothyroxine, Liothyronine ›
- Metformin ›
- Docusate ›
- Prednisone ›
- Tadalafil ›
- Amlodipine Besylate ›
- Amitriptyline ›
- Semaglutide ›
- Propranolol ›
- Amphetamine ›
- Methamphetamine ›
- Lisdexamfetamine ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Lisinopril ›
- Amoxicillin ›
- Methotrexate ›
- Bupropion ›
- Azithromycin ›
- Fluoxetine ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Dextroamphetamine ›
- Lamotrigine ›
- Clonazepam ›
- Quetiapine ›
- Buspirone ›
- Acyclovir ›
- Bendamustine ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Kamala list.
Sources & How We Checked
We checked Kamala against Diphenhydramine Hydrochloride, Naproxen Sodium in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diphenhydramine Hydrochloride, Naproxen Sodium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diphenhydramine Hydrochloride, Naproxen Sodium as a medicine that can lower these. This is not an interaction with Kamala — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diphenhydramine Hydrochloride, Naproxen Sodium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions
Is it safe to take Kamala with Diphenhydramine Hydrochloride, Naproxen Sodium?
Should I take Kamala and Diphenhydramine Hydrochloride, Naproxen Sodium at the same time of day?
Does Diphenhydramine Hydrochloride, Naproxen Sodium interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Diphenhydramine Hydrochloride, Naproxen Sodium and Kamala?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.