Laxogenin + Dextromethorphan HBr, Guaifenesin
Dextromethorphan HBr, Guaifenesin brand names: Vicks Formula 44E Cough & Chest Congestion Relief, Pediatric Vicks Formula 44e Cough & Chest Congesti.
We found no known interaction between Laxogenin and Dextromethorphan HBr, Guaifenesin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Laxogenin and Dextromethorphan HBr, Guaifenesin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dextromethorphan HBr, Guaifenesin and Laxogenin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Laxogenin at all — not against Dextromethorphan HBr, Guaifenesin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Laxogenin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Dextromethorphan HBr, Guaifenesin
This page covers Laxogenin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan HBr, Guaifenesin page lists 171 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).
By severity: 4 major · 125 moderate · 42 minor.
From our pharmacist’s overview on the Dextromethorphan HBr, Guaifenesin page
“A bad cough tends to hit when supplements are already on the counter, and anyone reaching for Vicks Formula 44E (dextromethorphan HBr and guaifenesin) should treat this list with real care, since 4 of its 171 entries carry a major rating. Two themes dominate.”
Reviewed by 2 · Jul 18, 2026
Taking Laxogenin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 17 real supplement products containing Laxogenin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Laxogenin. Even though Laxogenin itself has no known interaction with Dextromethorphan HBr, Guaifenesin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Laxogenin and Dextromethorphan HBr, Guaifenesin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,216 of 1,452 supplements looked up here in the last 7 days
#1,394 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Laxogenin is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Laxogenin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Laxogenin and Dextromethorphan HBr, Guaifenesin records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Laxogenin
What is Laxogenin?
- Muscle building and strength
- Exercise recovery
- Body recomposition / fat loss support
- Athletic performance
- Promoted as a 'natural anabolic'
Laxogenin is a plant-based steroid-like compound marketed mostly to bodybuilders for muscle growth and recovery, but there is very little human research to show it actually works. Because product quality and safety are not well studied, it is best to be cautious, and it should be avoided during pregnancy and breastfeeding.
Plant-derived steroidal sapogenin (often sourced from Smilax species or made semi-synthetically) · Capsules, tablets, liquid drops, powders, and combination 'natural anabolic' supplements
An interaction check asks whether these two react with each other — it does not ask whether Laxogenin is a good idea for someone in your situation. Here is what our Laxogenin record says about it on its own.
Laxogenin: dosing
There is no established or proven dose for laxogenin. Doses on product labels vary widely from brand to brand and are not backed by clinical research.If you choose to use it, follow the directions on the product label and do not exceed them. Choosing products that have been third-party tested (for example by NSF or USP) can help reduce the risk of contamination, though it does not prove the product works.
From our Laxogenin monograph — the full record covers uses, side effects and every documented interaction.
About Dextromethorphan HBr, Guaifenesin
Most-Reported Side Effects for Dextromethorphan HBr, Guaifenesin
From FAERS, the FDA’s public side-effect reporting system (1,675 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Laxogenin
Browse every other medication we’ve checked against Laxogenin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Laxogenin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Bupropion ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Pregabalin ›
- Gabapentin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Naproxen ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Laxogenin list.
Laxogenin References
The 3 sources that drive our Laxogenin monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Laxogenin is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Laxogenin and Dextromethorphan HBr, Guaifenesin Together: Common Questions
Is it safe to take Laxogenin with Dextromethorphan HBr, Guaifenesin?
Does Dextromethorphan HBr, Guaifenesin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.