Liver Extract + Sofosbuvir, Velpatasvir, Voxilaprevir
Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.
We found no known interaction between Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to.
Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Liver Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Liver Extract safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sofosbuvir, Velpatasvir, Voxilaprevir
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sofosbuvir, Velpatasvir, Voxilaprevir is filed under 9 classifications — including cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2c8 (cyp2c8) substrates, cytochrome p450 1a2 (cyp1a2) substrates. Liver Extract has documented interactions with 2 drug classes — the most serious being iron (minor) and warfarin (coumadin) (minor) — and none of Sofosbuvir, Velpatasvir, Voxilaprevir’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Liver Extract Does Interact With Other Medications
Liver Extract has 3 minor known drug interactions in our database — Sofosbuvir, Velpatasvir, Voxilaprevir isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Liver Extract
We haven’t checked that one against Liver Extract yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Liver Extract. Pick one to open its full report.
Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Liver Extract Should Not Break It
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Liver Extract on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Sofosbuvir, Velpatasvir, Voxilaprevir Is Prescribed For, and What Liver Extract Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Sofosbuvir, Velpatasvir, Voxilaprevir is a prescription medicine with approved uses on its FDA label. Liver Extract is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Sofosbuvir, Velpatasvir, Voxilaprevir is prescribed for: Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option. Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.
Liver Extract has been studied for:
-
Hepatitis C studied, not established Liver Extract has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Liver Extract for hepatitis c
Preliminary clinical research suggests that intravenous treatment with liver extract plus flavin adenine dinucleotide improves response to interferon-beta therapy in patients with hepatitis C. Also, giving a specific combination of liver extract and flavin adenine dinucleotide (Adelavin) intravenously or intramuscularly appears to improve hepatitis C virus RNA levels in patients with hepatitis C who are being treated…
2 sources cited
- 59952. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
- 59964. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sofosbuvir, Velpatasvir, Voxilaprevir on your own; if you are taking Liver Extract for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir
This page covers Liver Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 130 moderate · 40 minor.
From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page
“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”
Reviewed by 2 · Jul 18, 2026
Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page
Taking Liver Extract as Part of a Dietary Supplement Product? Check It for Interactions
We hold 595 real supplement products containing Liver Extract, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Liver Extract. Even though Liver Extract itself has no known interaction with Sofosbuvir, Velpatasvir, Voxilaprevir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#256 of 1,452 supplements looked up here in the last 7 days
#597 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Liver Extract reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Liver Extract
What is Liver Extract?
- Anemia and low iron
- Vitamin B12 support
- General energy and fatigue
- Nutritional support for athletes
- Liver health support
Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before purified vitamins became available, but today there is little modern evidence that it offers benefits beyond what a balanced diet or standard supplements provide. Talk with your pharmacist or doctor before using it, especially if you are pregnant, have liver disease, or have iron overload conditions.
Liver tissue, usually from cattle (beef) or pork · Capsules, tablets, powders, desiccated (dried) liver supplements, and injectable forms (prescription/historical)
An interaction check asks whether these two react with each other — it does not ask whether Liver Extract is a good idea for someone in your situation. Here is what our Liver Extract record says about it on its own.
Liver Extract: dosing
There is no official, standardized dose of liver extract, and products vary widely in how concentrated they are. Different brands also contain different amounts of vitamin A, iron, and B12.The safest approach is to follow the dose on the product label and not exceed it. They can help you decide whether you actually need it and whether a standard, purified vitamin would be a safer, more reliable choice.
From our Liver Extract monograph — the full record covers uses, side effects and every documented interaction.
About Sofosbuvir, Velpatasvir, and Voxilaprevir
What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?
Brand name: Vosevi
Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option.
Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.
Other Drugs & Liver Extract
Browse every other medication we’ve checked against Liver Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
3 interactions
No interaction 2,826 drugs checked — show the list
We also checked Liver Extract against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Methotrexate ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Isotretinoin ›
- Fluoxetine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Liver Extract list.
Liver Extract References
The 4 references that drive our Liver Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
- Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
- Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions
Is it safe to take Liver Extract with Sofosbuvir, Velpatasvir, Voxilaprevir?
Should I take Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
Are Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir used for the same thing?
How was the Liver Extract and Sofosbuvir, Velpatasvir, Voxilaprevir combination checked?
Does Liver Extract interact with any other medications?
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.