Drug & supplement interaction

Liverwort + Duvelisib

Duvelisib brand name: Copiktra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Liverwort and Duvelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Liverwort and Duvelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Duvelisib and Liverwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Liverwort at all — not against Duvelisib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Liverwort safety at a glance

Liverwort overall Use caution The fresh plant can irritate skin and mucous membranes, and human safety data are very limited.
Pregnancy Likely Unsafe When used orally or topically. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of dried liverwort while b... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Duvelisib and Liverwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Liverwort and Duvelisib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea reported in 14.0% of FDA reports for Duvelisib Additional detail

    Liverwort

    “Orally, fresh liverwort has been reported to cause diarrhea, gastrointestinal irritation (18), and kidney and urinary tract irritation (2). Topically, fresh liverwort has been reported to cause irritation, itching, and pustule formation known as ranunculus dermatitis (2). There is currently a limited amount of information available on the adverse effects of dried liverwort.”

    Liverwort · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

    “Orally, fresh liverwort has been reported to cause diarrhea and gastrointestinal irritation (18).”

    Liverwort · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Liverwort

    “Topically, fresh liverwort has been reported to cause irritation, itching, and pustule formation known as ranunculus dermatitis (2). In one case report, fresh liverwort was associated with contact hypersensitivity.”

    Liverwort · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 59971. Storrs, F. J., Mitchell, J. C., and Rasmussen, J. E. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686.

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib. Read the label on DailyMed ›

Reported for Liverwort but not commonly for Duvelisib: an allergic reaction and itching.

Effects for Duvelisib come from the ADVERSE REACTIONS section of its FDA label; effects for Liverwort come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 765 voluntary FDA FAERS reports for Duvelisib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Liverwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally or topically.

Lactation Likely Unsafe

When the fresh above ground parts are used orally or topically. There is insufficient reliable information available about the safety of dried liverwort while breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Duvelisib

This page covers Liverwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duvelisib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Duvelisib page

“Duvelisib (Copiktra) treats certain blood cancers, and its supplement list deserves genuine care because the body clears it through a single enzyme, CYP3A4. Most of the 143 ingredients either block or speed up that enzyme, which can push duvelisib levels high enough to worsen side effects or low enough to weaken its grip on the cancer.”

Reviewed by 2 · Jul 18, 2026

Open the Duvelisib interaction page

One more smart check

Taking Liverwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Liverwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Liverwort. Even though Liverwort itself has no known interaction with Duvelisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Liverwort and Duvelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Liverwort
Steady interest

#1,089 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Duvelisib
Steady interest

#1,474 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Liverwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Liverwort and Duvelisib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Liverwort

What is Liverwort?

Liverwort
  • Liver and gallbladder complaints
  • Digestive upset
  • Mild gallbladder discomfort
  • Respiratory or throat irritation
  • Skin conditions (traditional use)

Liverwort (Anemone hepatica) is a traditional herb once used for liver, gallbladder, and digestive complaints, but there is no reliable human research showing it works for any condition. The fresh plant belongs to the buttercup family and can irritate the skin and digestive tract, so it should only be used dried and with caution. Talk to your pharmacist or doctor before trying it.

Anemone hepatica · Ranunculaceae · Above-ground parts (leaves and flowers) · Tea, dried herb, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Liverwort is a good idea for someone in your situation. Here is what our Liverwort record says about it on its own.

Liverwort: dosing

There is no established or standardized dose for liverwort. Because it has not been studied in proper clinical trials, no safe and effective amount has been confirmed.If you choose to use a product that contains liverwort, follow the directions on the label and use only properly dried material, never the fresh plant. When in doubt, choose better-studied options with a clearer safety record.

From our Liverwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Liverwort monograph & all interactions
Medication

About Duvelisib

What Is Duvelisib Used For?

Brand name: Copiktra

Copiktra (duvelisib) is used in adults with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) — meaning the cancer has returned or stopped responding to treatment — after at least two prior therapies.

Copiktra is also used for relapsed or refractory follicular lymphoma (FL) after at least two prior systemic therapies. The follicular lymphoma approval is based on overall response rate and is considered an accelerated approval; continued approval may depend on results from confirmatory trials. Copiktra is not intended for use as a first- or second-line treatment for any of these cancers.

Most-Reported Side Effects for Duvelisib

From FAERS, the FDA’s public side-effect reporting system (765 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 107 reports
Fatigue 78 reports
Prescribed underdose 65 reports
Nausea 49 reports
Pneumonia 41 reports
See full Duvelisib drug information
Keep checking

Other Drugs & Liverwort

Browse every other medication we’ve checked against Liverwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Liverwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Liverwort list.

See the full Liverwort interactions page
See every supplement checked against Duvelisib, ranked by severity
Evidence & sources

Liverwort References

The 3 references that drive our Liverwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Storrs, F. J., Mitchell, J. C., and Rasmussen, J. E. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Liverwort and Duvelisib Together: Common Questions

Is it safe to take Liverwort with Duvelisib?
We do not list a known interaction between Liverwort and Duvelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Liverwort and Duvelisib have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Duvelisib interact with any supplements?
Yes. Duvelisib has documented interactions with 143 supplements in our database — Liverwort is not one of them. The Duvelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Liverwort monograph Uses, safety profile, and every drug interaction in one place Duvelisib drug information The full plain-English guide to this medication Duvelisib supplement interactions Every supplement checked against Duvelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Duvelisib and Liverwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.