Drug & supplement interaction

Lunasin + Sotalol

Sotalol brand names: Betapace AF, Betapace, Sotacor, Sorine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lunasin and Sotalol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lunasin and Sotalol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sotalol and Lunasin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lunasin at all — not against Sotalol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lunasin safety at a glance

Lunasin overall Not established Lunasin is found in common foods, but the safety of concentrated supplements has not been well studied.
Pregnancy Avoid There is not enough safety data, so concentrated supplements should be avoided during pregnancy.
Breastfeeding Avoid There is not enough safety data, so concentrated supplements should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sotalol and Lunasin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Lunasin and Sotalol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Nausea Additional detail

    Lunasin

    “There is currently a limited amount of information on the adverse effects of lunasin. Orally, adverse effects reported in clinical research include nausea, constipation (including obstipation), diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

    “Orally, lunasin can cause nausea, constipation, diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence. Two cases of obstipation requiring hospitalization have been reported following administration of lunasin.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

    Sotalol

    Listed in the ADVERSE REACTIONS section of the FDA label for Sotalol. Read the label on DailyMed ›

Reported for Lunasin but not commonly for Sotalol: reduced appetite, stomach pain, constipation and bloating or gas.

Effects for Sotalol come from the ADVERSE REACTIONS section of its FDA label; effects for Lunasin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Sotalol

This page covers Lunasin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sotalol page lists 43 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 26 moderate · 9 minor.

From our pharmacist’s overview on the Sotalol page

“Sotalol controls heart rhythm by lengthening the heart's electrical reset time, the QT interval, which is why this list of 43 interacting supplements deserves a careful read, not a skim. Eight are rated major, and most of the serious entries stack further QT prolongation on top of what sotalol already causes, raising the risk of a dang…”

Reviewed by 2 · Jul 18, 2026

Open the Sotalol interaction page

How much people look this up

Where Lunasin and Sotalol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lunasin
Steady interest

#915 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sotalol
Top 25%

#591 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lunasin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lunasin and Sotalol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lunasin

What is Lunasin?

  • Cholesterol and heart health
  • General immune support
  • Antioxidant support
  • Anti-inflammatory support
  • Cancer-prevention interest (unproven)

Lunasin is a small protein (peptide) found naturally in soybeans and some other seeds and grains. Laboratory and animal studies suggest it may have antioxidant, anti-inflammatory, and cholesterol-related effects, but solid human evidence is very limited. Talk with your pharmacist or doctor before using a lunasin supplement.

Seeds (most studied in soybean) · Capsules, powders, and protein extracts (often soy-derived)

An interaction check asks whether these two react with each other — it does not ask whether Lunasin is a good idea for someone in your situation. Here is what our Lunasin record says about it on its own.

Lunasin: dosing

There is no established standard dose for lunasin supplements. The amounts used in research vary, and product labels differ from brand to brand.If you choose to try a product, follow the directions on the label and do not exceed them. Because quality and purity of supplements can vary, look for brands that use independent third-party testing.

From our Lunasin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lunasin monograph & all interactions
Medication

About Sotalol

What Is Sotalol Used For?

Brand names: Betapace AF, Betapace, Sotacor, Sorine

Sotalol is used to treat documented, life-threatening ventricular arrhythmias (dangerous irregular heart rhythms originating in the lower chambers of the heart), such as sustained ventricular tachycardia (a rapid, sustained abnormal heartbeat). Because it carries real risks of its own, it is generally reserved for arrhythmias serious enough to be life-threatening — not for mild or symptom-only rhythm problems.

It is not recommended for people with less severe arrhythmias, even if those arrhythmias cause symptoms, and it should be avoided in people with asymptomatic (no-symptom) extra heartbeats called ventricular premature contractions.

See full Sotalol drug information
Keep checking

Other Drugs & Lunasin

Browse every other medication we’ve checked against Lunasin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lunasin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lunasin list.

See the full Lunasin interactions page
See every supplement checked against Sotalol, ranked by severity
Evidence & sources

Lunasin References

The 2 references that drive our Lunasin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
  2. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lunasin and Sotalol Together: Common Questions

Is it safe to take Lunasin with Sotalol?
We do not list a known interaction between Lunasin and Sotalol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lunasin and Sotalol have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Sotalol interact with any supplements?
Yes. Sotalol has documented interactions with 43 supplements in our database — Lunasin is not one of them. The Sotalol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lunasin monograph Uses, safety profile, and every drug interaction in one place Sotalol drug information The full plain-English guide to this medication Sotalol supplement interactions Every supplement checked against Sotalol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sotalol and Lunasin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.