Medication interaction hub

What Supplements Interact with Sotalol?

Sotalol brand names: Betapace AF, Betapace, Sotacor, Sorine, Sotylize. Every interaction below applies to the brands too.

43 Interactions 8 Major 26 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sotalol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sotalol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Sotalol controls heart rhythm by lengthening the heart's electrical reset time, the QT interval, which is why this list of 43 interacting supplements deserves a careful read, not a skim. Eight are rated major, and most of the serious entries stack further QT prolongation on top of what sotalol already causes, raising the risk of a dangerous rhythm. Grapefruit in large amounts sits on that major list, and so does ephedra.

The rest runs lower stakes but is worth knowing. Seventeen entries, everyday calcium among them, can change how much sotalol you absorb, most by blunting it, so space those doses well apart and check the full entries for timing. A few add to the drug's blood pressure and heart rate effects, and six may nudge the seizure threshold down. Among the 26 moderate and 9 minor ratings, absorption problems dominate; the eight majors are the ones to learn first.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 26 Minor 9 No known interaction 1,409

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Sotalol: Top Interactions at a Glance

The Sotalol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 43 interacting ingredients — plus 1,409 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Sotalol Combinations Today

The Sotalol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Bitter Orange + Sotaloli

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Read the full interaction Major Likelihood Probable Grapefruit + Sotaloli

Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT interval-prolonging drug...

Read the full interaction Moderate Likelihood Possible Guar Gum + Sotaloli

Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Sotaloli

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Sotaloli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Sotaloli

Arsenic trioxide can prolong the QT interval.

Read the full interaction
The complete list

Every Supplement Checked Against Sotalol

All 1,452 ingredients in our database, ranked by severity — 43 with a Sotalol interaction on file and 1,409 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sotalol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bitter Orange with Sotalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Sotalol answer

Can you take Grapefruit with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT inte...

Full Grapefruit + Sotalol answer

Can you take Guar Gum with Sotalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Sotalol answer

Can you take Blond Psyllium with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Sotalol answer

Can you take Slippery Elm with Sotalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Sotalol answer

Can you take Thuja with Sotalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Sotalol answer

Can you take Tragacanth with Sotalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Sotalol answer

Can you take Thyroid Extract with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Sotalol answer

Can you take Agar with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Sotalol answer

Can you take Algin with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Sotalol answer

Can you take Black Psyllium with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Sotalol answer

Can you take Carob with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Sotalol answer

Can you take Karaya Gum with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Sotalol answer

Can you take Marshmallow with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Sotalol answer

Can you take Xanthan Gum with Sotalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Sotalol answer

Can you take Activated Charcoal with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Sotalol answer

Can you take Arsenic with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Sotalol answer

Can you take Cesium with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Sotalol answer

Can you take Ephedra with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Sotalol answer

Can you take Indian Snakeroot with Sotalol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking Indian snakeroot with beta-blockers might increase the risk of bradycardia and/or hypotension.

Full Indian Snakeroot + Sotalol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sotalol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sotalol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sotalol sits in 5 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Sotalol through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Sotalol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Sotalol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Sotalol through this category.

Sotalol (Betapace) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Sotalol through this category.

About Sotalol

Sotalol is a prescription heart-rhythm medicine used to treat serious, life-threatening irregular heartbeats.

Generic name: Sotalol  ·  Brand names: Betapace AF, Betapace, Sotacor, Sorine, Sotylize.

See the full Sotalol drug information

Related: does Sotalol deplete any nutrients?

Sotalol has 4 reported nutrient associations in the research literature — see the Sotalol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sotalol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sotalol.

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Pharmacist Counseling Corner

Sotalol & Supplements: Common Questions

What supplements interact with Sotalol?
Our database currently documents 43 ingredients with a known Sotalol interaction (8 major, 26 moderate, 9 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 43. The highest-ranked right now: Activated Charcoal, Arsenic, Cesium.
Which Sotalol supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Arsenic, Cesium, Ephedra and Grapefruit, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Sotalol?
Plenty of supplements coexist fine with Sotalol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Betapace AF have the same supplement interactions as Sotalol?
Yes — Betapace AF, Betapace, Sotacor, Sorine, Sotylize all contain Sotalol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Sotalol deplete any vitamins or nutrients?
It might — Sotalol has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Sotalol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Sotalol and my other medications?
This page covers Sotalol against supplements and herbal ingredients. Checking Sotalol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Sotalol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.