Drug & supplement interaction

Bulbous Buttercup + Sotalol

Sotalol brand names: Betapace AF, Betapace, Sotacor, Sorine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bulbous Buttercup and Sotalol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bulbous Buttercup and Sotalol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sotalol and Bulbous Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Bulbous Buttercup at all — not against Sotalol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bulbous Buttercup safety at a glance

Bulbous Buttercup overall Avoid The fresh plant is toxic and irritating; only highly diluted homeopathic forms are used, and these are unproven.
Pregnancy Likely Unsafe When used orally or topically; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sotalol and Bulbous Buttercup? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Bulbous Buttercup and Sotalol May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Bulbous Buttercup

    “Orally, ingestion of bulbous buttercup can cause severe irritation of the urinary and gastrointestinal tracts, with colic and diarrhea (18).

    Topically, skin contact can cause blisters and burns that are difficult to heal (18).”

    Bulbous Buttercup · Natural Medicines adverse-effect record, reported in burns.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, ingestion of bulbous buttercup may cause severe irritation of the gastrointestinal tract, with colic and diarrhea (18).”

    Bulbous Buttercup · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Sotalol

    Listed in the ADVERSE REACTIONS section of the FDA label for Sotalol. Read the label on DailyMed ›

Effects for Sotalol come from the ADVERSE REACTIONS section of its FDA label; effects for Bulbous Buttercup come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bulbous Buttercup in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sotalol

This page covers Bulbous Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sotalol page lists 43 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 26 moderate · 9 minor.

From our pharmacist’s overview on the Sotalol page

“Sotalol controls heart rhythm by lengthening the heart's electrical reset time, the QT interval, which is why this list of 43 interacting supplements deserves a careful read, not a skim. Eight are rated major, and most of the serious entries stack further QT prolongation on top of what sotalol already causes, raising the risk of a dang…”

Reviewed by 2 · Jul 18, 2026

Open the Sotalol interaction page

One more smart check

Taking Bulbous Buttercup as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Bulbous Buttercup, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bulbous Buttercup. Even though Bulbous Buttercup itself has no known interaction with Sotalol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bulbous Buttercup and Sotalol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bulbous Buttercup
Steady interest

#1,365 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sotalol
Top 25%

#505 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bulbous Buttercup reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bulbous Buttercup and Sotalol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bulbous Buttercup

What is Bulbous Buttercup?

  • Nerve pain and shingles-related discomfort (homeopathic use)
  • Muscle and chest wall pain
  • Skin blistering and eruptions (traditional)
  • Rheumatic aches (folk use)

Bulbous buttercup is a wild flowering plant that is toxic and irritating when fresh, and it is used today mainly in heavily diluted homeopathic remedies. There is no solid scientific evidence that it treats any medical condition, and the raw plant can cause serious skin and digestive harm, so it should not be eaten or applied directly.

Ranunculus bulbosus · Ranunculaceae · Whole fresh plant, leaves, and flowers (mainly used in homeopathic preparations) · Homeopathic dilutions (pellets, liquid), rarely topical folk preparations

An interaction check asks whether these two react with each other — it does not ask whether Bulbous Buttercup is a good idea for someone in your situation. Here is what our Bulbous Buttercup record says about it on its own.

Bulbous Buttercup: dosing

There is no established safe or effective dose of bulbous buttercup for any health condition. The raw plant should not be taken at all.If a homeopathic product is used, follow the directions on the label, since potencies and dosing vary widely between products.

From our Bulbous Buttercup monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bulbous Buttercup monograph & all interactions
Medication

About Sotalol

What Is Sotalol Used For?

Brand names: Betapace AF, Betapace, Sotacor, Sorine

Sotalol is used to treat documented, life-threatening ventricular arrhythmias (dangerous irregular heart rhythms originating in the lower chambers of the heart), such as sustained ventricular tachycardia (a rapid, sustained abnormal heartbeat). Because it carries real risks of its own, it is generally reserved for arrhythmias serious enough to be life-threatening — not for mild or symptom-only rhythm problems.

It is not recommended for people with less severe arrhythmias, even if those arrhythmias cause symptoms, and it should be avoided in people with asymptomatic (no-symptom) extra heartbeats called ventricular premature contractions.

See full Sotalol drug information
Keep checking

Other Drugs & Bulbous Buttercup

Browse every other medication we’ve checked against Bulbous Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Bulbous Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Bulbous Buttercup list.

See the full Bulbous Buttercup interactions page
See every supplement checked against Sotalol, ranked by severity
Evidence & sources

Bulbous Buttercup References

The 1 references that drive our Bulbous Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bulbous Buttercup and Sotalol Together: Common Questions

Is it safe to take Bulbous Buttercup with Sotalol?
We do not list a known interaction between Bulbous Buttercup and Sotalol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bulbous Buttercup and Sotalol have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Sotalol interact with any supplements?
Yes. Sotalol has documented interactions with 43 supplements in our database — Bulbous Buttercup is not one of them. The Sotalol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bulbous Buttercup monograph Uses, safety profile, and every drug interaction in one place Sotalol drug information The full plain-English guide to this medication Sotalol supplement interactions Every supplement checked against Sotalol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sotalol and Bulbous Buttercup?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.