Methasterone + Amphetamine
Amphetamine brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER.
We found no known interaction between Methasterone and Amphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Methasterone and Amphetamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Amphetamine and Methasterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Methasterone at all — not against Amphetamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Methasterone safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Methasterone in Pregnancy & Breastfeeding
When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Amphetamine Is Prescribed For, and What Methasterone Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Amphetamine is a prescription medicine with approved uses on its FDA label. Methasterone is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Amphetamine is prescribed for: Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group. Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.
Methasterone has been studied for:
-
Obesity studied, not established Methasterone has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Methasterone for obesity
Although there is interest in using methasterone for weight loss, there is insufficient reliable information about the clinical effects of methasterone for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amphetamine on your own; if you are taking Methasterone for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Methasterone or Amphetamine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Methasterone or Amphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can Vyvanse Chewable Tablets Be Crushed? ›
- Concerned About A Friend Taking Adderall XR Capsules The Wrong Way ›
- Adderall With Alka-Seltzer Interaction Details ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Amphetamine
This page covers Methasterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amphetamine page lists 130 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Bitter Orange (major), Brewer's Yeast (major) and Cowhage (major).
By severity: 16 major · 97 moderate · 17 minor.
From our pharmacist’s overview on the Amphetamine page
“Amphetamine (Dyanavel XR, Adzenys ER, Mydayis) is a prescription stimulant, usually taken for ADHD, and its interaction list is one to approach with genuine care. Of the 130 supplements and herbal ingredients on file, 16 carry a major rating, and many of those work the same way, either inhibiting monoamine oxidase, as yohimbe does, or…”
Reviewed by 2 · Jul 18, 2026
Where Methasterone and Amphetamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#754 of 1,452 supplements looked up here in the last 7 days
#29 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methasterone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Methasterone and Amphetamine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Methasterone
What is Methasterone?
- Muscle building
- Athletic performance
- Strength gains
- Body recomposition
Methasterone (also called methyldrostanolone or 'Superdrol') is a synthetic, oral anabolic steroid — not a dietary supplement, herb, or natural product. It is a controlled substance in the United States and has been linked to serious liver damage and other harms, so it should not be used outside of legitimate medical or research settings.
Synthetic compound (not derived from a plant) · Oral capsules or tablets (illicit/gray-market products)
An interaction check asks whether these two react with each other — it does not ask whether Methasterone is a good idea for someone in your situation. Here is what our Methasterone record says about it on its own.
Methasterone: dosing
There is no safe or medically established dose for methasterone. It is not an approved medicine or legitimate supplement, and we will not provide dosing guidance for it.Because of its serious risks and its status as a controlled substance, the safest amount is none.
From our Methasterone monograph — the full record covers uses, side effects and every documented interaction.
About Amphetamine
What Is Amphetamine Used For?
Brand names: Dyanavel XR, Adensys XR-ODT, Mydayis, Adzenys ER
Amphetamine treats Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. Adzenys XR-ODT, Dyanavel XR, and the amphetamine extended-release orally disintegrating tablet formulations are specifically approved for ADHD in this age group.
Amphetamine Sulfate tablets and Evekeo (amphetamine sulfate tablets) are also approved for narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness) and as a short-term aid in a calorie-restricted weight-loss program for exogenous obesity (weight gain from external factors like overeating) in patients who have not responded to other approaches.
Most-Reported Side Effects for Amphetamine
From FAERS, the FDA’s public side-effect reporting system (50,216 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Methasterone
Browse every other medication we’ve checked against Methasterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Methasterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Amlodipine Besylate ›
- Docusate ›
- Methamphetamine ›
- Amitriptyline ›
- Prednisone ›
- Metformin ›
- Tadalafil ›
- Lisdexamfetamine ›
- Semaglutide ›
- Hydroxyurea ›
- Valacyclovir ›
- Propranolol ›
- Sumatriptan ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Fluoxetine ›
- Bupropion ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Acetaminophen, Aspirin, Caffeine ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Lamotrigine ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methasterone list.
Methasterone References
The 1 references that drive our Methasterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Methasterone and Amphetamine Together: Common Questions
Is it safe to take Methasterone with Amphetamine?
Are Methasterone and Amphetamine used for the same thing?
Does Amphetamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Amphetamine and Methasterone?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.