Drug & supplement interaction

Methylstenbolone + Silodosin

Silodosin brand name: Rapaflo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Methylstenbolone and Silodosin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Silodosin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Methylstenbolone and Silodosin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Silodosin and Methylstenbolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Methylstenbolone at all — not against Silodosin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Methylstenbolone safety at a glance

Methylstenbolone overall Avoid It is an unapproved synthetic anabolic steroid linked to serious liver and hormonal harm.
Pregnancy Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Silodosin and Methylstenbolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Methylstenbolone and Silodosin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    Methylstenbolone

    “There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to 1 month. Liver enzyme levels gradually decreased after discontinuation.”

    Methylstenbolone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108298. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

    Silodosin

    Listed in the ADVERSE REACTIONS section of the FDA label for Silodosin. Read the label on DailyMed ›

  • Itching Additional detail

    Methylstenbolone

    Recorded for Methylstenbolone in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

    Silodosin

    Listed in the ADVERSE REACTIONS section of the FDA label for Silodosin. Read the label on DailyMed ›

Reported for Methylstenbolone but not commonly for Silodosin: liver problems.

Effects for Silodosin come from the ADVERSE REACTIONS section of its FDA label; effects for Methylstenbolone come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Methylstenbolone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Silodosin Products Have a Food Rule — Methylstenbolone Should Not Break It

At least one FDA label for a product containing Silodosin says to take it with food. If you take Methylstenbolone on an empty stomach out of habit, keep them separate — and take Silodosin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Silodosin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION 8 mg capsules taken orally once daily with a meal.

From the Dosage and Administration section of the FDA label we read for Silodosin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Methylstenbolone or Silodosin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Methylstenbolone or Silodosin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Silodosin

This page covers Methylstenbolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Silodosin page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 104 moderate · 38 minor.

From our pharmacist’s overview on the Silodosin page

“Grapefruit is the first risk I'd flag for anyone taking silodosin (Rapaflo) for an enlarged prostate. It blocks CYP3A4, the enzyme that clears silodosin, so blood levels rise, and higher levels mean more dizziness, lightheadedness, and fainting when standing.”

Reviewed by 2 · Jul 18, 2026

Open the Silodosin interaction page

One more smart check

Taking Methylstenbolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Methylstenbolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Methylstenbolone. Even though Methylstenbolone itself has no known interaction with Silodosin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Methylstenbolone and Silodosin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Methylstenbolone
Steady interest

#1,079 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Silodosin
Steady interest

#2,026 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylstenbolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Methylstenbolone and Silodosin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Methylstenbolone

What is Methylstenbolone?

  • Muscle building (bodybuilding)
  • Strength gains
  • Body recomposition
  • Athletic performance enhancement

Methylstenbolone is a synthetic, oral anabolic-androgenic steroid that has been sold in some 'prosteroid' or 'designer supplement' products, not a natural herb. It is not an approved or safe dietary supplement, it carries real risks including serious liver damage, and it is banned in sports and prohibited in many countries. We strongly recommend against using it and urge you to speak with a doctor or pharmacist first.

Synthetic compound (not derived from a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Methylstenbolone is a good idea for someone in your situation. Here is what our Methylstenbolone record says about it on its own.

Methylstenbolone: dosing

There is no established, safe, or approved dose for methylstenbolone. It is not a recognized medicine or legitimate dietary supplement, so no medical dosing guidance exists.We will not provide dosing amounts because doing so could encourage harmful use. If you have taken a product that contains methylstenbolone, stop and talk with a healthcare professional. Never assume a product is safe just because it is sold online or in a store.

From our Methylstenbolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Methylstenbolone monograph & all interactions
Medication

About Silodosin

What Is Silodosin Used For?

Brand name: Rapaflo

Silodosin capsules are approved to treat the signs and symptoms of benign prostatic hyperplasia (BPH) — the non-cancerous enlargement of the prostate that can make urination difficult, weak, or frequent. It helps ease those urinary symptoms so urine can flow more freely.

It is important to know that silodosin is not approved for treating high blood pressure, even though it affects certain receptors that can influence blood pressure.

Most-Reported Side Effects for Silodosin

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 156 reports
Fatigue 149 reports
Dizziness 141 reports
Acute kidney injury 139 reports
Anemia 126 reports
See full Silodosin drug information
Keep checking

Other Drugs & Methylstenbolone

Browse every other medication we’ve checked against Methylstenbolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Methylstenbolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methylstenbolone list.

See the full Methylstenbolone interactions page
See every supplement checked against Silodosin, ranked by severity
Evidence & sources

Methylstenbolone References

The 2 references that drive our Methylstenbolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Methylstenbolone and Silodosin Together: Common Questions

Is it safe to take Methylstenbolone with Silodosin?
We do not list a known interaction between Methylstenbolone and Silodosin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Methylstenbolone and Silodosin have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Methylstenbolone and Silodosin at the same time of day?
At least one FDA label for a product containing Silodosin says to take it with food. If you take Methylstenbolone on an empty stomach out of habit, keep them separate and take Silodosin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Silodosin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Silodosin interact with any supplements?
Yes. Silodosin has documented interactions with 145 supplements in our database — Methylstenbolone is not one of them. The Silodosin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Methylstenbolone monograph Uses, safety profile, and every drug interaction in one place Silodosin drug information The full plain-English guide to this medication Silodosin supplement interactions Every supplement checked against Silodosin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Silodosin and Methylstenbolone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.