Mezereon + Atovaquone
Atovaquone brand name: Mepron.
We found no known interaction between Mezereon and Atovaquone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Mezereon and Atovaquone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Atovaquone and Mezereon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Mezereon at all — not against Atovaquone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Mezereon safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Mezereon in Pregnancy & Breastfeeding
When used orally or topically; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Atovaquone Products Have a Food Rule — Mezereon Should Not Break It
At least one FDA label for a product containing Atovaquone says to take it with food. If you take Mezereon on an empty stomach out of habit, keep them separate — and take Atovaquone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
jirovecii Pneumonia The recommended oral dosage is 1,500 mg (10 mL) once daily administered with food.
From the Dosage and Administration section of the FDA label we read for Atovaquone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Atovaquone
This page covers Mezereon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Atovaquone page
“Atovaquone (Mepron) is usually taken to prevent or treat Pneumocystis pneumonia, often when the immune system is already weakened, so a dose that never absorbs is a treatment failure, not a nuisance. All 17 supplement interactions on file act in the gut, changing how much of the drug reaches the blood, and I read this list as one deser…”
Reviewed by 2 · Jul 18, 2026
Where Mezereon and Atovaquone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,135 of 1,452 supplements looked up here in the last 7 days
#425 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mezereon reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mezereon and Atovaquone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Mezereon
What is Mezereon?
- Skin conditions and ulcers (traditional)
- Joint and rheumatic pain (traditional)
- Counter-irritant on the skin
- Homeopathic remedies for skin eruptions
Mezereon is a poisonous European shrub whose bark and berries have been used in traditional and homeopathic medicine, but it is highly toxic and irritating. There is no reliable scientific evidence that it safely treats any condition, and swallowing any part of the plant can be dangerous. It should not be used as a home remedy.
Daphne mezereum · Thymelaeaceae · Bark and berries (rarely the dried bark used in traditional preparations) · Homeopathic preparations, traditional tinctures, and topical ointments
An interaction check asks whether these two react with each other — it does not ask whether Mezereon is a good idea for someone in your situation. Here is what our Mezereon record says about it on its own.
Mezereon: dosing
There is no established safe dose of mezereon for any medical use. Because the plant is poisonous, pharmacists and doctors do not recommend taking it.Highly diluted homeopathic products are sometimes sold, but these are not proven to work, and you should never use raw bark, berries, or homemade tinctures.
From our Mezereon monograph — the full record covers uses, side effects and every documented interaction.
About Atovaquone
What Is Atovaquone Used For?
Brand name: Mepron
Atovaquone oral suspension — available as the brand Mepron and as generic products — is used in adults and adolescents aged 13 and older who cannot tolerate trimethoprim-sulfamethoxazole (TMP-SMX), the usual first-choice treatment.
It is approved for two purposes: preventing PCP in people at high risk, and treating mild-to-moderate PCP in those who already have it. It has not been studied for severe PCP or for people whose PCP is not responding to TMP-SMX, so it is not used in those situations.
Other Drugs & Mezereon
Browse every other medication we’ve checked against Mezereon — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Mezereon against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mezereon list.
Mezereon References
The 1 references that drive our Mezereon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Mezereon and Atovaquone Together: Common Questions
Is it safe to take Mezereon with Atovaquone?
Do Mezereon and Atovaquone have any of the same side effects?
Should I take Mezereon and Atovaquone at the same time of day?
Does Atovaquone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Atovaquone and Mezereon?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.