Drug & supplement interaction

Mezereon + Maralixibat

Maralixibat brand name: Livmarli.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mezereon and Maralixibat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mezereon and Maralixibat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Maralixibat and Mezereon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mezereon at all — not against Maralixibat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mezereon safety at a glance

Mezereon overall Avoid Mezereon is a poisonous plant that can cause severe irritation and serious poisoning.
Pregnancy Likely Unsafe When used orally or topically; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Maralixibat and Mezereon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mezereon and Maralixibat May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain Additional detail

    Mezereon

    “Orally, mezereon is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Topically, mezereon can cause significant irritation.

    Most Common Adverse Effects:

    Orally: Abdominal pain, diarrhea, reddening and swelling of the oral mucous membranes, salivation, thirst, vomiting.

    Topically: Blistering, redness, swelling.”

    Mezereon · Natural Medicines adverse-effect record, reported in diarrhea.

    Maralixibat

    Listed in the ADVERSE REACTIONS section of the FDA label for Maralixibat. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Mezereon

    “Orally, mezereon can cause reddening and swelling of the oral mucous membranes, salivation, thirst, stomach pains, vomiting, and severe diarrhea (18).”

    Mezereon · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Maralixibat

    Listed in the ADVERSE REACTIONS section of the FDA label for Maralixibat. Read the label on DailyMed ›

Reported for Mezereon but not commonly for Maralixibat: a fast or pounding heartbeat, dizziness, headache and swelling.

Effects for Maralixibat come from the ADVERSE REACTIONS section of its FDA label; effects for Mezereon come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Mezereon in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Maralixibat

This page covers Mezereon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Maralixibat page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Maralixibat page

“Maralixibat (Livmarli) relieves the severe itching caused by rare childhood liver diseases like Alagille syndrome, and since it does its job inside the intestine, this list warrants genuine vigilance, not a shrug. All 17 supplement entries share one mechanism, ingredients that trap or slow drugs in the gut and change how much of a dose…”

Reviewed by 2 · Jul 18, 2026

Open the Maralixibat interaction page

How much people look this up

Where Mezereon and Maralixibat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mezereon
Steady interest

#1,155 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Maralixibat
Steady interest

#2,134 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mezereon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mezereon and Maralixibat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mezereon

What is Mezereon?

  • Skin conditions and ulcers (traditional)
  • Joint and rheumatic pain (traditional)
  • Counter-irritant on the skin
  • Homeopathic remedies for skin eruptions

Mezereon is a poisonous European shrub whose bark and berries have been used in traditional and homeopathic medicine, but it is highly toxic and irritating. There is no reliable scientific evidence that it safely treats any condition, and swallowing any part of the plant can be dangerous. It should not be used as a home remedy.

Daphne mezereum · Thymelaeaceae · Bark and berries (rarely the dried bark used in traditional preparations) · Homeopathic preparations, traditional tinctures, and topical ointments

An interaction check asks whether these two react with each other — it does not ask whether Mezereon is a good idea for someone in your situation. Here is what our Mezereon record says about it on its own.

Mezereon: dosing

There is no established safe dose of mezereon for any medical use. Because the plant is poisonous, pharmacists and doctors do not recommend taking it.Highly diluted homeopathic products are sometimes sold, but these are not proven to work, and you should never use raw bark, berries, or homemade tinctures.

From our Mezereon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mezereon monograph & all interactions
Medication

About Maralixibat

What Is Maralixibat Used For?

Brand name: Livmarli

Livmarli (maralixibat) is used to treat cholestatic pruritus (intense itching caused by bile acid buildup in the body) in two rare liver conditions. It is approved for patients aged 3 months and older with Alagille syndrome (ALGS), and for patients aged 12 months and older with progressive familial intrahepatic cholestasis (PFIC).

There is an important limitation for PFIC: Livmarli is not recommended for a specific subgroup of PFIC type 2 patients who have certain gene variants (ABCB11 variants) that result in a non-functional or completely absent bile salt export pump (BSEP) protein.

See full Maralixibat drug information
Keep checking

Other Drugs & Mezereon

Browse every other medication we’ve checked against Mezereon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mezereon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mezereon list.

See the full Mezereon interactions page
See every supplement checked against Maralixibat, ranked by severity
Evidence & sources

Mezereon References

The 1 references that drive our Mezereon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mezereon and Maralixibat Together: Common Questions

Is it safe to take Mezereon with Maralixibat?
We do not list a known interaction between Mezereon and Maralixibat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mezereon and Maralixibat have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Maralixibat interact with any supplements?
Yes. Maralixibat has documented interactions with 17 supplements in our database — Mezereon is not one of them. The Maralixibat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mezereon monograph Uses, safety profile, and every drug interaction in one place Maralixibat drug information The full plain-English guide to this medication Maralixibat supplement interactions Every supplement checked against Maralixibat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Maralixibat and Mezereon?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.