Drug & supplement interaction

Mindfulness + Enzalutamide

Enzalutamide brand name: Xtandi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mindfulness and Enzalutamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mindfulness and Enzalutamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Enzalutamide and Mindfulness in our sources. This does not guarantee that the combination is completely free of risk — research on Mindfulness alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Mindfulness at all — not against Enzalutamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Mindfulness is a practice rather than something you take. Ask your care team whether the type and intensity you plan to practice are appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mindfulness safety at a glance

Mindfulness overall Generally safe Mindfulness is generally very safe for most people and has no swallowed dose or chemical risk.
Pregnancy Generally safe Mindfulness practices are generally considered safe during pregnancy and may help with stress.
Breastfeeding Generally safe There is no known risk to breastfeeding from practicing mindfulness.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Enzalutamide and Mindfulness? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Mindfulness and Enzalutamide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so practicing Mindfulness while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Anxiety or restlessness Additional detail

    Mindfulness

    “Some studies report rare cases of anger, worsening anxiety, and thoughts of self-harm in patients, but these effects could have been caused by the underlying ailment rather than practicing mindfulness.”

    Mindfulness · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 100273. Hilton L, Hempel S, Ewing BA, et al. Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis. Ann Behav Med. 2017;51(2):199-213. PubMed
    2. 105414. Zgierska AE, Burzinski CA, Mundt MP, et al. Mindfulness-based relapse prevention for alcohol dependence: Findings from a randomized controlled trial. J Subst Abuse Treat. 2019 May;100:8-17. PubMed
    3. 109368. Hoge EA, Bui E, Mete M, Dutton MA, Baker AW, Simon NM. Mindfulness-based stress reduction vs escitalopram for the treatment of adults with anxiety disorders: A randomized clinical trial. JAMA Psychiatry. 2022:e223679. PubMed

    Enzalutamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Enzalutamide. Read the label on DailyMed ›

Reported for Mindfulness but not commonly for Enzalutamide: thoughts of self-harm.

Effects for Enzalutamide come from the ADVERSE REACTIONS section of its FDA label; effects for Mindfulness come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 58,437 voluntary FDA FAERS reports for Enzalutamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Enzalutamide

This page covers Mindfulness only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enzalutamide page lists 49 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Black Tea (moderate) and Boneset (moderate).

By severity: 1 major · 36 moderate · 12 minor.

Open the Enzalutamide interaction page

How much people look this up

Where Mindfulness and Enzalutamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mindfulness
Top half

#437 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Enzalutamide
Top half

#1,391 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mindfulness reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mindfulness and Enzalutamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Mind-body practice

About Mindfulness

What is Mindfulness?

  • Stress reduction
  • Anxiety and depression
  • Chronic pain
  • Sleep problems
  • Improving focus and emotional well-being

Mindfulness is a mind-body practice—not a pill or herb—that involves paying attention to the present moment without judgment. Research suggests it can modestly help with stress, anxiety, depression, and chronic pain for many people, and it is generally very safe. It is best used alongside, not in place of, care from your doctor or pharmacist.

Not applicable (mind-body practice) · Guided meditation, breathing exercises, body scans, mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) programs, apps, classes

An interaction check asks whether these two react with each other — it does not ask whether Mindfulness is a good idea for someone in your situation. Here is what our Mindfulness record says about it on its own.

Mindfulness: dosing

There is no standardized "dose" for mindfulness. Many structured programs, such as MBSR, run for about eight weeks with daily home practice, but you do not need a formal program to benefit.A common starting point is a few minutes of practice per day, gradually building up as it feels comfortable. Even short, regular sessions can help.

From our Mindfulness monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mindfulness monograph & all interactions
Medication

About Enzalutamide

What Is Enzalutamide Used For?

Brand name: Xtandi

Xtandi (enzalutamide) is used to treat prostate cancer in three specific situations: castration-resistant prostate cancer (CRPC), metastatic castration-sensitive prostate cancer (mCSPC), and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (high-risk BCR).

Castration-resistant means the cancer has continued to grow despite low testosterone levels. Castration-sensitive means the cancer still responds to testosterone-lowering therapy. In most of these cases, Xtandi is used alongside a GnRH analog (a hormone-lowering injection) or after surgical removal of the testicles — except in the high-risk BCR setting, where it may be used with or without a GnRH analog.

Most-Reported Side Effects for Enzalutamide

From FAERS, the FDA’s public side-effect reporting system (58,437 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 10,267 reports
Malignant neoplasm progression 5,468 reports
Prostatic specific antigen increased 4,344 reports
Asthenia 4,171 reports
Hot flush 3,882 reports
See full Enzalutamide drug information
Keep checking

Other Drugs & Mindfulness

Browse every other medication we’ve checked against Mindfulness — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mindfulness against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mindfulness list.

See the full Mindfulness interactions page
See every supplement checked against Enzalutamide, ranked by severity
Evidence & sources

Mindfulness References

The 3 references that drive our Mindfulness monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hilton L, Hempel S, Ewing BA, et al. Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis. Ann Behav Med. 2017;51(2):199-213. PubMed
  2. Zgierska AE, Burzinski CA, Mundt MP, et al. Mindfulness-based relapse prevention for alcohol dependence: Findings from a randomized controlled trial. J Subst Abuse Treat. 2019 May;100:8-17. PubMed
  3. Hoge EA, Bui E, Mete M, Dutton MA, Baker AW, Simon NM. Mindfulness-based stress reduction vs escitalopram for the treatment of adults with anxiety disorders: A randomized clinical trial. JAMA Psychiatry. 2022:e223679. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Practicing Mindfulness While Taking Enzalutamide: Common Questions

Is it safe to practice Mindfulness while taking Enzalutamide?
We do not list a known interaction between Mindfulness and Enzalutamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mindfulness and Enzalutamide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Enzalutamide interact with any supplements?
Yes. Enzalutamide has documented interactions with 49 supplements in our database — Mindfulness is not one of them. The Enzalutamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mindfulness monograph Uses, safety profile, and every drug interaction in one place Enzalutamide drug information The full plain-English guide to this medication Enzalutamide supplement interactions Every supplement checked against Enzalutamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Enzalutamide and Mindfulness?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.