Drug & supplement interaction

Myrcia + pioglitazone, metformin

pioglitazone, metformin brand name: ActoPlus Met.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Myrcia and pioglitazone, metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for pioglitazone, metformin states a food rule worth keeping to.

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Interaction report

Myrcia and pioglitazone, metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between pioglitazone, metformin and Myrcia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Myrcia safety at a glance

Myrcia overall Not established Human safety data are very limited, so caution is advised.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining pioglitazone, metformin and Myrcia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for pioglitazone, metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. pioglitazone, metformin is filed under 8 classifications — including organic cation transporter 2 (oct2) substrates, cytochrome p450 2c8 (cyp2c8) substrates, antidiabetes drugs. Myrcia has documented interactions with 1 drug class — the most serious being levothyroxine (synthroid, others) (moderate) — and none of pioglitazone, metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Myrcia Does Interact With Other Medications

Myrcia has 3 moderate known drug interactions in our database — pioglitazone, metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 3 No known interaction 2,827 (incl. pioglitazone, metformin)
Taking anything else?

Check Another of Your Medications Against Myrcia

Covers the 2,830 medications we’ve checked against Myrcia. Pick one to open its full report.

What to actually watch for

What pioglitazone, metformin’s Own FDA Label Lists

This is not an interaction — none of it involves Myrcia. These are the most notable effects listed in the ADVERSE REACTIONS section of pioglitazone, metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • A heart attack Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • Chest pain Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Weight gain
  • Pain in an arm or leg
  • Bloating or gas

Showing the 10 most notable of 21 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for pioglitazone, metformin. Read the label on DailyMed › Myrcia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Myrcia side to compare — that is a limit of the record, not a statement that Myrcia has no side effects.

How to take them

Some pioglitazone, metformin Products Have a Food Rule — Myrcia Should Not Break It

At least one FDA label for a product containing pioglitazone, metformin says to take it with food. If you take Myrcia on an empty stomach out of habit, keep them separate — and take pioglitazone, metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two pioglitazone, metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Take orally with meals to reduce gastrointestinal adverse reactions with metformin ( 2.10 ) Individualize the starting dose based on the patient’s current regimen and titrate the dosage gradually, as needed after assessing therapeutic response and tolerability.

From the Dosage and Administration section of the FDA label we read for pioglitazone, metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With pioglitazone, metformin

This page covers Myrcia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the pioglitazone, metformin page lists 357 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 311 moderate · 40 minor.

From our pharmacist’s overview on the pioglitazone, metformin page

“ActoPlus Met pairs pioglitazone with metformin for type 2 diabetes, and the size of this list, 357 supplements in all, reflects how many herbs lower blood sugar on their own. Stacked with the drug, they can push glucose too low; most of the 311 moderate entries work exactly that way.”

Reviewed by 2 · Jul 18, 2026

Open the pioglitazone, metformin interaction page

How much people look this up

Where Myrcia and pioglitazone, metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Myrcia
Steady interest

#1,039 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication pioglitazone, metformin
Steady interest

#2,372 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Myrcia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Myrcia and pioglitazone, metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Myrcia

What is Myrcia?

  • Blood sugar support
  • Digestive upset and diarrhea
  • Mild urinary complaints
  • Astringent for the gut
  • Traditional 'pedra-hume-caa' folk remedy

Myrcia is a group of tropical shrubs and trees in the myrtle family, used in South American folk medicine—often as a tea—mainly for blood sugar and digestive complaints. Human evidence is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you have diabetes or take other medicines.

Myrtaceae · Leaves (and sometimes bark) · Tea, dried leaf, capsules, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Myrcia is a good idea for someone in your situation. Here is what our Myrcia record says about it on its own.

Myrcia: dosing

There is no established standardized dose for Myrcia. Traditional use is usually as a tea made from the dried leaves, but amounts vary widely and are not backed by clinical research.If you choose to try a commercial product, follow the directions on the label and do not exceed them.

From our Myrcia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Myrcia monograph & all interactions
Keep checking

Other Drugs & Myrcia

Browse every other medication we’ve checked against Myrcia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
3Moderate
0Minor
2,826No known interaction
3 Moderate 2,826 No interaction
Moderate

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Myrcia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Myrcia list.

See the full Myrcia interactions page
See every supplement checked against pioglitazone, metformin, ranked by severity
Evidence & sources

Myrcia References

The 2 references that drive our Myrcia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Russo EM, Reichelt AA, De Sa JR, et al. Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients. Braz J Med Biol Res 1990;23(1):11-20.
  2. Ferreira AC, Neto JC, da Silva AC, et al. Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids. Chem Res Toxicol 2006;19(3):351-55.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Myrcia and pioglitazone, metformin Together: Common Questions

Is it safe to take Myrcia with pioglitazone, metformin?
We do not list a known interaction between Myrcia and pioglitazone, metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Myrcia and pioglitazone, metformin at the same time of day?
At least one FDA label for a product containing pioglitazone, metformin says to take it with food. If you take Myrcia on an empty stomach out of habit, keep them separate and take pioglitazone, metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two pioglitazone, metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Myrcia and pioglitazone, metformin combination checked?
Interactions in our licensed database are recorded against drug classes. pioglitazone, metformin is filed under 8 classifications, and Myrcia has documented interactions with 1 drug class — none of pioglitazone, metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Myrcia interact with any other medications?
Yes. Myrcia has 3 documented drug interactions in our database — pioglitazone, metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does pioglitazone, metformin interact with any supplements?
Yes. pioglitazone, metformin has documented interactions with 357 supplements in our database — Myrcia is not one of them. The pioglitazone, metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Myrcia monograph Uses, safety profile, and every drug interaction in one place pioglitazone, metformin supplement interactions Every supplement checked against pioglitazone, metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.