Drug & supplement interaction

Nadh + Linaclotide

Linaclotide brand name: Linzess.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Nadh and Linaclotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Linaclotide states a food rule worth keeping to.

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Interaction report

Nadh and Linaclotide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Linaclotide and Nadh in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Nadh at all — not against Linaclotide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nadh safety at a glance

Nadh overall Use caution Generally well tolerated short-term, but long-term safety and quality data are limited.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Linaclotide and Nadh? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Linaclotide’s Own FDA Label Lists

This is not an interaction — none of it involves Nadh. These are the most notable effects listed in the ADVERSE REACTIONS section of Linaclotide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on
  • Heartburn
  • Bloating or gas mentioned in 4.4% of FDA reports for Linaclotide
  • Diarrhea mentioned in 17.7% of FDA reports for Linaclotide
  • Constipation mentioned in 7.5% of FDA reports for Linaclotide
  • Stomach pain mentioned in 4.0% of FDA reports for Linaclotide
  • Headache mentioned in 3.9% of FDA reports for Linaclotide
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Linaclotide. Read the label on DailyMed › Where a percentage is shown, it is the share of 26,525 voluntary FDA FAERS reports for Linaclotide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Nadh’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Nadh side to compare — that is a limit of the record, not a statement that Nadh has no side effects.

How to take them

Some Linaclotide Products Have a Food Rule — Nadh Should Not Break It

At least one FDA label for a product containing Linaclotide says to take it on an empty stomach. Most supplements — Nadh included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Linaclotide on its own and move Nadh to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Linaclotide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Preparation and Administration Instructions • Take LINZESS on an empty stomach, at least 30 minutes prior to a meal at approximately the same time each day.

From the Dosage and Administration section of the FDA label we read for Linaclotide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Nadh or Linaclotide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Nadh or Linaclotide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Linaclotide

This page covers Nadh only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linaclotide page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Linaclotide page

“Linaclotide (Linzess) treats IBS with constipation by acting inside the intestine itself, so the capsule's contents have to reach the gut unbound to do their job. That is exactly what the 17 supplements on this page can interfere with, and I would read the list with genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Linaclotide interaction page

One more smart check

Taking Nadh as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Nadh, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nadh. Even though Nadh itself has no known interaction with Linaclotide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Nadh and Linaclotide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nadh
Steady interest

#960 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Linaclotide
Steady interest

#1,879 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Nadh is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nadh reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nadh and Linaclotide records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Nadh

What is Nadh?

  • Chronic fatigue syndrome
  • Low energy and tiredness
  • Athletic performance
  • Mental clarity and focus
  • Parkinson's disease (investigational)
  • Jet lag

NADH is the active, electron-carrying form of niacin (vitamin B3) that your body uses to make energy in cells. Some people take it as a supplement for fatigue, mental sharpness, and athletic performance, but solid human evidence is limited and mostly preliminary. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before trying it.

Not applicable (a coenzyme form of vitamin B3/niacin) · Tablets, capsules, sublingual lozenges, sometimes intravenous (clinical settings)

An interaction check asks whether these two react with each other — it does not ask whether Nadh is a good idea for someone in your situation. Here is what our Nadh record says about it on its own.

Nadh: dosing

There is no official, standardized dose of NADH. Doses used in studies have varied, and product strengths differ from brand to brand. Sublingual (under-the-tongue) forms are marketed as being better absorbed, though strong proof for this is limited.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Taking it earlier in the day may help avoid sleep problems.

From our Nadh monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nadh monograph & all interactions
Medication

About Linaclotide

What Is Linaclotide Used For?

Brand name: Linzess

Linzess (linaclotide) treats three related conditions that cause difficult, infrequent bowel movements. In adults, it is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC — ongoing constipation with no identified cause). In children ages 7 and older, Linzess is approved for IBS-C. In children ages 2 and older, Linzess is approved for functional constipation (FC).

Most-Reported Side Effects for Linaclotide

From FAERS, the FDA’s public side-effect reporting system (26,525 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 4,703 reports
Constipation 1,998 reports
Nausea 1,476 reports
Fatigue 1,171 reports
Abdominal distension 1,170 reports
See full Linaclotide drug information
Keep checking

Other Drugs & Nadh

Browse every other medication we’ve checked against Nadh — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Nadh against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nadh list.

See the full Nadh interactions page
See every supplement checked against Linaclotide, ranked by severity
Evidence & sources

Nadh References

The 1 sources that drive our Nadh monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Nadh is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Niacin - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nadh and Linaclotide Together: Common Questions

Is it safe to take Nadh with Linaclotide?
We do not list a known interaction between Nadh and Linaclotide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Nadh and Linaclotide at the same time of day?
At least one FDA label for a product containing Linaclotide says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Linaclotide on its own and move Nadh to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Linaclotide interact with any supplements?
Yes. Linaclotide has documented interactions with 17 supplements in our database — Nadh is not one of them. The Linaclotide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nadh monograph Uses, safety profile, and every drug interaction in one place Linaclotide drug information The full plain-English guide to this medication Linaclotide supplement interactions Every supplement checked against Linaclotide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Linaclotide and Nadh?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.