Nadh + Pembrolizumab
Pembrolizumab brand name: Keytruda.
We found no known interaction between Nadh and Pembrolizumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Nadh and Pembrolizumab
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pembrolizumab and Nadh in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Nadh at all — not against Pembrolizumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Nadh safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Pembrolizumab
This page covers Nadh only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pembrolizumab page lists 1 supplement it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Pawpaw (minor).
By severity: 1 minor.
From our pharmacist’s overview on the Pembrolizumab page
“For a drug used against so many different cancers, pembrolizumab (Keytruda) has a remarkably short supplement file. Just one ingredient appears on it, American pawpaw, and even that lone entry is rated minor and judged unlikely to cause real trouble.”
Reviewed by 2 · Jul 18, 2026
Taking Nadh as Part of a Dietary Supplement Product? Check It for Interactions
We hold 3 real supplement products containing Nadh, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nadh. Even though Nadh itself has no known interaction with Pembrolizumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Nadh and Pembrolizumab Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#971 of 1,452 supplements looked up here in the last 7 days
#831 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Nadh is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nadh reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nadh and Pembrolizumab records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Nadh
What is Nadh?
- Chronic fatigue syndrome
- Low energy and tiredness
- Athletic performance
- Mental clarity and focus
- Parkinson's disease (investigational)
- Jet lag
NADH is the active, electron-carrying form of niacin (vitamin B3) that your body uses to make energy in cells. Some people take it as a supplement for fatigue, mental sharpness, and athletic performance, but solid human evidence is limited and mostly preliminary. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before trying it.
Not applicable (a coenzyme form of vitamin B3/niacin) · Tablets, capsules, sublingual lozenges, sometimes intravenous (clinical settings)
An interaction check asks whether these two react with each other — it does not ask whether Nadh is a good idea for someone in your situation. Here is what our Nadh record says about it on its own.
Nadh: dosing
There is no official, standardized dose of NADH. Doses used in studies have varied, and product strengths differ from brand to brand. Sublingual (under-the-tongue) forms are marketed as being better absorbed, though strong proof for this is limited.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Taking it earlier in the day may help avoid sleep problems.
From our Nadh monograph — the full record covers uses, side effects and every documented interaction.
About Pembrolizumab Injection
What Is Pembrolizumab Injection Used For?
Brand name: Keytruda
Pembrolizumab is used to treat a wide range of cancers — including melanoma (skin cancer), lung cancer, head and neck cancers, bladder cancer, certain colorectal cancers, cervical cancer, kidney cancer, liver cancer, and many others. It can be used alone or combined with chemotherapy, depending on the cancer type and stage.
For some cancers, it's given before surgery (neoadjuvant), after surgery (adjuvant), or both — to help shrink tumors or reduce the chance the cancer comes back. Some uses require a lab test to confirm your tumor has certain markers (like PD-L1 expression) before starting treatment.
Most-Reported Side Effects for Pembrolizumab
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Nadh
Browse every other medication we’ve checked against Nadh — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Nadh against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Abemaciclib ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Clopidogrel ›
- Escitalopram ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bendamustine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nadh list.
Nadh References
The 1 sources that drive our Nadh monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Nadh is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Niacin - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Nadh and Pembrolizumab Together: Common Questions
Is it safe to take Nadh with Pembrolizumab?
Does Pembrolizumab interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Pembrolizumab and Nadh?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.