Drug & supplement interaction

Oleic Acid + Atovaquone, Proguanil

Atovaquone, Proguanil brand name: Malarone.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Oleic Acid and Atovaquone, Proguanil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone, Proguanil states a food rule worth keeping to.

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Interaction report

Oleic Acid and Atovaquone, Proguanil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atovaquone, Proguanil and Oleic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Oleic Acid safety at a glance

Oleic Acid overall Generally safe Generally recognized as safe when consumed in normal amounts from foods like olive oil.
Pregnancy Use caution Amounts found in foods are fine, but concentrated supplements are not well studied in pregnancy.
Breastfeeding Use caution Food amounts are considered safe, but supplement-level doses lack good safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atovaquone, Proguanil and Oleic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atovaquone, Proguanil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atovaquone, Proguanil is filed under 3 classifications — cytochrome p450 2c19 (cyp2c19) substrates, seizure threshold lowering drugs, oral drugs. Oleic Acid has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Atovaquone, Proguanil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Oleic Acid Does Interact With Other Medications

Oleic Acid has 86 moderate known drug interactions in our database — Atovaquone, Proguanil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Atovaquone, Proguanil)
Taking anything else?

Check Another of Your Medications Against Oleic Acid

Covers the 2,830 medications we’ve checked against Oleic Acid. Pick one to open its full report.

What to actually watch for

What Atovaquone, Proguanil’s Own FDA Label Lists

This is not an interaction — none of it involves Oleic Acid. These are the most notable effects listed in the ADVERSE REACTIONS section of Atovaquone, Proguanil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • Mouth irritation or sores
  • Cough
  • Reduced appetite
  • Trouble sleeping
  • Fever
  • Itching
  • Stomach pain
  • Tiredness
  • Dizziness

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Atovaquone, Proguanil. Read the label on DailyMed › Oleic Acid’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Oleic Acid side to compare — that is a limit of the record, not a statement that Oleic Acid has no side effects.

How to take them

Some Atovaquone, Proguanil Products Have a Food Rule — Oleic Acid Should Not Break It

At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Oleic Acid on an empty stomach out of habit, keep them separate — and take Atovaquone, Proguanil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone, Proguanil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The daily dose should be taken at the same time each day with food or a milky drink.

From the Dosage and Administration section of the FDA label we read for Atovaquone, Proguanil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atovaquone, Proguanil

This page covers Oleic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone, Proguanil page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).

By severity: 1 major · 40 moderate · 13 minor.

From our pharmacist’s overview on the Atovaquone, Proguanil page

“Most people taking atovaquone-proguanil (Malarone) are travelers trying to prevent malaria, so this list of 54 interacting supplements deserves real attention, since anything that weakens the drug can leave you exposed to the disease itself. The single major-rated entry is activated charcoal, a common travel remedy for stomach upset, w…”

Reviewed by 2 · Jul 18, 2026

Open the Atovaquone, Proguanil interaction page

One more smart check

Taking Oleic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,803 real supplement products containing Oleic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oleic Acid. Even though Oleic Acid itself has no known interaction with Atovaquone, Proguanil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oleic Acid and Atovaquone, Proguanil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oleic Acid
Top 25%

#185 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atovaquone, Proguanil
Steady interest

#2,082 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Oleic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Oleic Acid and Atovaquone, Proguanil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Oleic Acid

What is Oleic Acid?

  • Heart health
  • Healthy cooking fat
  • Skin moisturizing
  • Part of the Mediterranean diet
  • Anti-inflammatory support

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replacement for saturated fats, but it is still a calorie-dense fat, so amounts matter. Talk to your pharmacist or doctor before using concentrated supplements.

Fatty acid found in plant oils and animal fats · Olive oil, capsules, softgels, cooking oils, skin products

An interaction check asks whether these two react with each other — it does not ask whether Oleic Acid is a good idea for someone in your situation. Here is what our Oleic Acid record says about it on its own.

Oleic Acid: dosing

There is no official standardized dose of oleic acid as a supplement. Most people get healthy amounts simply by using olive oil and eating foods like nuts and avocados in place of less healthy fats.If you use an oleic acid product or olive oil supplement, follow the directions on the product label. Because it is a fat with calories, keep portion sizes reasonable.

From our Oleic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Oleic Acid monograph & all interactions
Medication

About Atovaquone and Proguanil

What Is Atovaquone and Proguanil Used For?

Brand name: Malarone

Atovaquone and proguanil is used for two purposes: preventing P. falciparum malaria before and during travel to areas where malaria is common, and treating an active, uncomplicated P. falciparum malaria infection. This includes regions where other antimalarials — such as chloroquine, mefloquine, halofantrine, and amodiaquine — may no longer be effective due to drug resistance.

Both the adult-strength and pediatric-strength tablet formulations share these same two approved uses. The brand Malarone is approved for both prevention and treatment of P. falciparum malaria in adults and in pediatric patients, with dosing based on body weight for children.

See full Atovaquone and Proguanil drug information
Keep checking

Other Drugs & Oleic Acid

Browse every other medication we’ve checked against Oleic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Oleic Acid page.

No interaction 2,743 drugs checked — show the list

We also checked Oleic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Oleic Acid list.

See the full Oleic Acid interactions page
See every supplement checked against Atovaquone, Proguanil, ranked by severity
Evidence & sources

Oleic Acid References

The 19 references that drive our Oleic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Oleic Acid and Atovaquone, Proguanil Together: Common Questions

Is it safe to take Oleic Acid with Atovaquone, Proguanil?
We do not list a known interaction between Oleic Acid and Atovaquone, Proguanil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Oleic Acid and Atovaquone, Proguanil at the same time of day?
At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Oleic Acid on an empty stomach out of habit, keep them separate and take Atovaquone, Proguanil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atovaquone, Proguanil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Oleic Acid and Atovaquone, Proguanil combination checked?
Interactions in our licensed database are recorded against drug classes. Atovaquone, Proguanil is filed under 3 classifications, and Oleic Acid has documented interactions with 1 drug class — none of Atovaquone, Proguanil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Oleic Acid interact with any other medications?
Yes. Oleic Acid has 86 documented drug interactions in our database — Atovaquone, Proguanil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atovaquone, Proguanil interact with any supplements?
Yes. Atovaquone, Proguanil has documented interactions with 54 supplements in our database — Oleic Acid is not one of them. The Atovaquone, Proguanil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Oleic Acid monograph Uses, safety profile, and every drug interaction in one place Atovaquone and Proguanil drug information The full plain-English guide to this medication Atovaquone, Proguanil supplement interactions Every supplement checked against Atovaquone, Proguanil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 19 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.