Drug & supplement interaction

Oleic Acid + Dulaglutide

Dulaglutide brand name: Trulicity.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Oleic Acid has a moderate interaction with Dulaglutide. Theoretically, oleic acid might increase the effects of antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Oleic Acid and Dulaglutide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Dulaglutide

Dulaglutide falls under ANTIDIABETES DRUGS — the group Oleic Acid interacts with.

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Trulicity (dulaglutide) and oleic acid: this isn't a chemical clash. Dulaglutide is a weekly injection that already lowers blood sugar, and oleic acid (the main fat in olive oil) may give blood sugar a gentle nudge downward too. The concern is simple addition, not one drug speeding up or slowing down the other. So in theory their combined effect could pull your numbers a little lower than expected.

Honestly, the evidence here is thin and based mostly on diet studies, not concentrated supplements, so I wouldn't lose sleep over olive oil on your salad. Just keep an eye out for low blood sugar signs (shakiness, sweating, dizziness), especially if you also take insulin or a sulfonylurea. Before starting any concentrated oleic acid supplement, run it by your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Oleic Acid Also Interacts With Other Medications

Oleic Acid has 85 moderate known drug interactions in our database — the Dulaglutide one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Dulaglutide)
Taking anything else?

Check Another of Your Medications Against Oleic Acid

Covers the 2,830 medications we’ve checked against Oleic Acid. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dulaglutide

This page covers Oleic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dulaglutide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Dulaglutide page

“Because dulaglutide (Trulicity) already lowers blood sugar in people with type 2 diabetes, nearly every entry on this page deserves genuine respect, and one demands it outright. Almost all of these supplements pull glucose in one direction or the other, so the danger that matters most is hypoglycemia, blood sugar dropping too low.”

Reviewed by 2 · Jul 18, 2026

Open the Dulaglutide interaction page

One more smart check

Taking Oleic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,803 real supplement products containing Oleic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oleic Acid. Your product may carry other ingredients that interact with Dulaglutide too, on top of Oleic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oleic Acid and Dulaglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oleic Acid
Top 25%

#185 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dulaglutide
Steady interest

#1,793 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Oleic Acid

What is Oleic Acid?

  • Heart health
  • Healthy cooking fat
  • Skin moisturizing
  • Part of the Mediterranean diet
  • Anti-inflammatory support

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replacement for saturated fats, but it is still a calorie-dense fat, so amounts matter. Talk to your pharmacist or doctor before using concentrated supplements.

Read the full Oleic Acid monograph & all interactions
Medication

About Dulaglutide Injection

What Is Dulaglutide Injection Used For?

Brand name: Trulicity

Trulicity (dulaglutide) injection is used alongside diet and exercise to improve blood sugar control in adults and children 10 years and older with type 2 diabetes mellitus. It is not for type 1 diabetes.

Trulicity is also used in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors to lower the risk of major heart events — specifically cardiovascular death, non-fatal heart attack, or non-fatal stroke.

See full Dulaglutide Injection drug information
Keep checking

Other Drugs & Oleic Acid

Browse every other medication we’ve checked against Oleic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Oleic Acid page.

No interaction 2,744 drugs checked — show the list

We also checked Oleic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Oleic Acid list.

See the full Oleic Acid interactions page
See every supplement checked against Dulaglutide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Oleic Acid monograph › Uses, safety, and every drug interaction in one place Dulaglutide supplement interactions › Every supplement checked against Dulaglutide, ranked by severity Dulaglutide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Oleic Acid and Dulaglutide Together: Common Questions

Can you take Oleic Acid with Dulaglutide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Oleic Acid and Dulaglutide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dulaglutide and Oleic Acid?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.