Ornithine Ketoglutarate (okg) + Pemetrexed
Pemetrexed brand names: Alimta, Pemfexy.
We found no known interaction between Ornithine Ketoglutarate (okg) and Pemetrexed in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Ornithine Ketoglutarate (okg) and Pemetrexed
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pemetrexed and Ornithine Ketoglutarate (okg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Ornithine Ketoglutarate (okg) at all — not against Pemetrexed, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ornithine Ketoglutarate (okg) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Pemetrexed
This page covers Ornithine Ketoglutarate (okg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pemetrexed page lists 4 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: African Wild Potato (moderate), Banderol (moderate), Caffeic Acid (moderate) and Quercetin (moderate).
By severity: 4 moderate.
From our pharmacist’s overview on the Pemetrexed page
“Every supplement on file for pemetrexed (Alimta, Pemfexy) works the same way. Each can slow how the kidneys pull the drug out of the blood, which would let it linger and build to higher levels than intended.”
Reviewed by 2 · Jul 18, 2026
Where Ornithine Ketoglutarate (okg) and Pemetrexed Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,407 of 1,452 supplements looked up here in the last 7 days
#696 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ornithine Ketoglutarate (okg) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ornithine Ketoglutarate (okg) and Pemetrexed records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ornithine Ketoglutarate (okg)
What is Ornithine Ketoglutarate (okg)?
- Wound healing and recovery from injury
- Muscle preservation in older or hospitalized adults
- Sports and athletic performance
- Recovery from burns or surgery
- Support during malnutrition or critical illness
Ornithine ketoglutarate (OKG) is a compound made by combining the amino acids ornithine and alpha-ketoglutarate, and it has mainly been studied in hospital settings for wound healing, burns, and malnutrition. Evidence for everyday use, such as sports performance, is limited and not convincing. Talk to your pharmacist or doctor before using it, especially if you have a health condition.
Not applicable (a synthesized amino acid salt) · Powder, capsules, tablets, and as part of clinical nutrition formulas
An interaction check asks whether these two react with each other — it does not ask whether Ornithine Ketoglutarate (okg) is a good idea for someone in your situation. Here is what our Ornithine Ketoglutarate (okg) record says about it on its own.
Ornithine Ketoglutarate (okg): dosing
There is no official standardized dose of OKG for general use. In clinical studies, doses were chosen by researchers and given to specific patient groups, often under medical care.If you use a supplement, follow the directions on the product label and do not assume more is better.
From our Ornithine Ketoglutarate (okg) monograph — the full record covers uses, side effects and every documented interaction.
About Pemetrexed Injection
What Is Pemetrexed Injection Used For?
Brand names: Alimta, Pemfexy
Pemetrexed Injection is used for non-squamous non-small cell lung cancer (NSCLC) in several situations: as an initial treatment (combined with pembrolizumab and platinum chemotherapy, or with cisplatin alone), as a maintenance treatment after platinum-based chemotherapy, or as a single agent when the cancer has come back after prior chemotherapy. It is not used for squamous cell non-small cell lung cancer.
Pemetrexed Injection is also used, in combination with cisplatin, for the initial treatment of malignant pleural mesothelioma — a cancer of the lining of the lungs — in patients whose disease cannot be surgically removed or who are not good candidates for surgery.
Most-Reported Side Effects for Pemetrexed
From FAERS, the FDA’s public side-effect reporting system (37,889 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Ornithine Ketoglutarate (okg)
Browse every other medication we’ve checked against Ornithine Ketoglutarate (okg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Ornithine Ketoglutarate (okg) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amitriptyline ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bupropion ›
- Bendamustine ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ornithine Ketoglutarate (okg) list.
Ornithine Ketoglutarate (okg) References
The 3 references that drive our Ornithine Ketoglutarate (okg) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Karsegard, V. L., Raguso, C. A., Genton, L., Hirschel, B., and Pichard, C. L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004;20(6):515-520.
- Meaume, S., Kerihuel, J. C., Constans, T., Teot, L., Lerebours, E., Kern, J., and Bourdel, Marchasson, I. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J.Nutr.H PubMed
- Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ornithine Ketoglutarate (okg) and Pemetrexed Together: Common Questions
Is it safe to take Ornithine Ketoglutarate (okg) with Pemetrexed?
Do Ornithine Ketoglutarate (okg) and Pemetrexed have any of the same side effects?
Does Pemetrexed interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Pemetrexed and Ornithine Ketoglutarate (okg)?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.