Drug & supplement interaction

Ornithine + Atovaquone, Proguanil

Atovaquone, Proguanil brand name: Malarone.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ornithine and Atovaquone, Proguanil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone, Proguanil states a food rule worth keeping to.

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Interaction report

Ornithine and Atovaquone, Proguanil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atovaquone, Proguanil and Ornithine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ornithine at all — not against Atovaquone, Proguanil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ornithine safety at a glance

Ornithine overall Use caution Generally well tolerated short-term, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Atovaquone, Proguanil and Ornithine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Atovaquone, Proguanil’s Own FDA Label Lists

This is not an interaction — none of it involves Ornithine. These are the most notable effects listed in the ADVERSE REACTIONS section of Atovaquone, Proguanil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • Mouth irritation or sores
  • Cough
  • Reduced appetite
  • Trouble sleeping
  • Fever
  • Itching
  • Stomach pain
  • Tiredness
  • Dizziness

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Atovaquone, Proguanil. Read the label on DailyMed › Ornithine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ornithine side to compare — that is a limit of the record, not a statement that Ornithine has no side effects.

How to take them

Some Atovaquone, Proguanil Products Have a Food Rule — Ornithine Should Not Break It

At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Ornithine on an empty stomach out of habit, keep them separate — and take Atovaquone, Proguanil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone, Proguanil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The daily dose should be taken at the same time each day with food or a milky drink.

From the Dosage and Administration section of the FDA label we read for Atovaquone, Proguanil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Atovaquone, Proguanil

This page covers Ornithine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone, Proguanil page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).

By severity: 1 major · 40 moderate · 13 minor.

From our pharmacist’s overview on the Atovaquone, Proguanil page

“Most people taking atovaquone-proguanil (Malarone) are travelers trying to prevent malaria, so this list of 54 interacting supplements deserves real attention, since anything that weakens the drug can leave you exposed to the disease itself. The single major-rated entry is activated charcoal, a common travel remedy for stomach upset, w…”

Reviewed by 2 · Jul 18, 2026

Open the Atovaquone, Proguanil interaction page

One more smart check

Taking Ornithine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 751 real supplement products containing Ornithine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ornithine. Even though Ornithine itself has no known interaction with Atovaquone, Proguanil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ornithine and Atovaquone, Proguanil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ornithine
Top 25%

#260 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atovaquone, Proguanil
Steady interest

#2,203 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Ornithine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ornithine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ornithine and Atovaquone, Proguanil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ornithine

What is Ornithine?

  • Athletic performance and recovery
  • Reducing fatigue
  • Sleep and stress support
  • Liver and ammonia metabolism support
  • Wound healing

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep, but human evidence is limited and mixed. Talk to your pharmacist or doctor before using it, especially if you have a medical condition.

Amino acid (not a plant part) · Capsules, tablets, powder, often as L-ornithine or ornithine alpha-ketoglutarate (OKG)

An interaction check asks whether these two react with each other — it does not ask whether Ornithine is a good idea for someone in your situation. Here is what our Ornithine record says about it on its own.

Ornithine: dosing

There is no official, standardized dose of ornithine for any supplement use. Amounts used in studies have varied widely, and there is not enough strong evidence to recommend a specific dose.The safest approach is to follow the directions on the product label and not exceed them.

From our Ornithine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ornithine monograph & all interactions
Medication

About Atovaquone and Proguanil

What Is Atovaquone and Proguanil Used For?

Brand name: Malarone

Atovaquone and proguanil is used for two purposes: preventing P. falciparum malaria before and during travel to areas where malaria is common, and treating an active, uncomplicated P. falciparum malaria infection. This includes regions where other antimalarials — such as chloroquine, mefloquine, halofantrine, and amodiaquine — may no longer be effective due to drug resistance.

Both the adult-strength and pediatric-strength tablet formulations share these same two approved uses. The brand Malarone is approved for both prevention and treatment of P. falciparum malaria in adults and in pediatric patients, with dosing based on body weight for children.

See full Atovaquone and Proguanil drug information
Keep checking

Other Drugs & Ornithine

Browse every other medication we’ve checked against Ornithine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ornithine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ornithine list.

See the full Ornithine interactions page
See every supplement checked against Atovaquone, Proguanil, ranked by severity
Evidence & sources

Ornithine References

The 1 sources that drive our Ornithine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Ornithine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ornithine and Atovaquone, Proguanil Together: Common Questions

Is it safe to take Ornithine with Atovaquone, Proguanil?
We do not list a known interaction between Ornithine and Atovaquone, Proguanil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Ornithine and Atovaquone, Proguanil at the same time of day?
At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Ornithine on an empty stomach out of habit, keep them separate and take Atovaquone, Proguanil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atovaquone, Proguanil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Atovaquone, Proguanil interact with any supplements?
Yes. Atovaquone, Proguanil has documented interactions with 54 supplements in our database — Ornithine is not one of them. The Atovaquone, Proguanil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ornithine monograph Uses, safety profile, and every drug interaction in one place Atovaquone and Proguanil drug information The full plain-English guide to this medication Atovaquone, Proguanil supplement interactions Every supplement checked against Atovaquone, Proguanil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atovaquone, Proguanil and Ornithine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.