Orris + Progestin, Oral Contraceptive
Progestin, Oral Contraceptive brand name: Slynd.
We found no known interaction between Orris and Progestin, Oral Contraceptive in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Orris and Progestin, Oral Contraceptive
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Progestin, Oral Contraceptive and Orris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Orris at all — not against Progestin, Oral Contraceptive, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Orris safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Progestin, Oral Contraceptive
This page covers Orris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Progestin, Oral Contraceptive page lists 139 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 95 moderate · 41 minor.
From our pharmacist’s overview on the Progestin, Oral Contraceptive page
“If you take Slynd, a progestin-only birth control pill, treat this list with real care, because anything that lowers the hormone level can weaken protection against pregnancy. Slynd is cleared by the CYP3A4 enzyme, and nearly all 139 ingredients on file touch that pathway one way or another.”
Reviewed by 2 · Jul 18, 2026
Taking Orris as Part of a Dietary Supplement Product? Check It for Interactions
We hold 36 real supplement products containing Orris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orris. Even though Orris itself has no known interaction with Progestin, Oral Contraceptive, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Orris and Progestin, Oral Contraceptive Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,153 of 1,452 supplements looked up here in the last 7 days
#287 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orris reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Orris and Progestin, Oral Contraceptive records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Orris
What is Orris?
- Fragrance and flavoring (perfumes, gin, cosmetics)
- Traditional remedy for coughs and congestion
- Skin and breath freshening
- Teething soothers for infants (traditional, not recommended)
- Digestive complaints (traditional use)
Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very little reliable human evidence that it treats any medical condition, and the fresh root can be irritating, so it is best thought of as a fragrance ingredient rather than a remedy. Talk to your pharmacist or doctor before using it for any health purpose.
Iris germanica · Iridaceae · Dried rhizome (orris root) and its essential oil/extract (orris butter) · Dried root pieces, powder, essential oil (orris butter), tinctures, and as a flavoring or fragrance ingredient
An interaction check asks whether these two react with each other — it does not ask whether Orris is a good idea for someone in your situation. Here is what our Orris record says about it on its own.
Orris: dosing
There is no established or standardized medicinal dose for orris root. Its main everyday uses—as a perfume ingredient or a flavoring—involve very small amounts and are not the same as taking it as a supplement.If you are considering a product that contains orris, follow the directions on the label and do not exceed them.
From our Orris monograph — the full record covers uses, side effects and every documented interaction.
About Progestin-Only (drospirenone) Oral Contraceptives
What Is Progestin-Only (drospirenone) Oral Contraceptives Used For?
Brand name: Slynd
-
Progestin-only (drospirenone) oral contraceptives are used to prevent pregnancy. Progestin is a female hormone. It works by preventing the release of eggs from the ovaries (ovulation) and changing the cervical mucus and the lining of the uterus. Progestin-only oral contraceptives are a very effective method of birth control, but they do not prevent the spread of of human immunodeficiency virus (HIV, the virus that causes acquired immunodeficiency syndrome [AIDS]) and other sexually transmitted diseases.
Other Drugs & Orris
Browse every other medication we’ve checked against Orris — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Orris against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orris list.
Orris References
The 3 references that drive our Orris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Orris and Progestin, Oral Contraceptive Together: Common Questions
Is it safe to take Orris with Progestin, Oral Contraceptive?
Does Progestin, Oral Contraceptive interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Progestin, Oral Contraceptive and Orris?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.