Medication interaction hub

What Supplements Interact with Progestin, Oral Contraceptive?

Progestin, Oral Contraceptive brand name: Slynd. Every interaction below applies to the brands too.

139 Interactions 3 Major 95 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Progestin, Oral Contraceptive? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Progestin, Oral Contraceptive against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take Slynd, a progestin-only birth control pill, treat this list with real care, because anything that lowers the hormone level can weaken protection against pregnancy. Slynd is cleared by the CYP3A4 enzyme, and nearly all 139 ingredients on file touch that pathway one way or another. St. John's wort is the one to rule out first; it speeds the hormone's breakdown enough to matter. Grapefruit pushes in the opposite direction, raising levels, and activated charcoal can bind the dose in your gut before it ever absorbs.

Most of the moderate entries nudge hormone levels up or down through that same enzyme, while a smaller cluster of charcoals and thick fibers can blunt absorption of anything swallowed, so space those well apart from your pill. Read the three major entries before the rest; the other 136 split into 95 moderates and 41 minors.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 95 Minor 41 No known interaction 1,313

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Progestin, Oral Contraceptive: Top Interactions at a Glance

The Progestin, Oral Contraceptive supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 139 interacting ingredients — plus 1,313 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Progestin, Oral Contraceptive Combinations Today

The Progestin, Oral Contraceptive + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Progestin, Oral Contraceptivei

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Green Tea + Progestin, Oral Contraceptivei

Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Kratom + Progestin, Oral Contraceptivei

Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Echinacea + Progestin, Oral Contraceptivei

Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Read the full interaction Minor Likelihood Possible Ashwagandha + Progestin, Oral Contraceptivei

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Progestin, Oral Contraceptivei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Progestin, Oral Contraceptive

All 1,452 ingredients in our database, ranked by severity — 139 with a Progestin, Oral Contraceptive interaction on file and 1,313 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Progestin, Oral Contraceptive?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Progestin, Oral Contraceptive answer

Can you take Green Tea with Progestin, Oral Contraceptive?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Progestin, Oral Contraceptive answer

Can you take Kratom with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Progestin, Oral Contraceptive answer

Can you take Echinacea with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Progestin, Oral Contraceptive answer

Can you take Ashwagandha with Progestin, Oral Contraceptive?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Progestin, Oral Contraceptive answer

Can you take Pregnenolone with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pregnenolone might enhance the effects of progestin.

Full Pregnenolone + Progestin, Oral Contraceptive answer

Can you take Propolis with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Progestin, Oral Contraceptive answer

Can you take Quercetin with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Progestin, Oral Contraceptive answer

Can you take Rabdosia Rubescens with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Progestin, Oral Contraceptive answer

Can you take Resveratrol with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Progestin, Oral Contraceptive answer

Can you take Rooibos with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP3A4 substrates may increase the effects of CYP3A4 substrates.

Full Rooibos + Progestin, Oral Contraceptive answer

Can you take Sage with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Sage + Progestin, Oral Contraceptive answer

Can you take Schizonepeta with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Progestin, Oral Contraceptive answer

Can you take Slippery Elm with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Progestin, Oral Contraceptive answer

Can you take Sulforaphane with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Progestin, Oral Contraceptive answer

Can you take Sweet Annie with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Progestin, Oral Contraceptive answer

Can you take Syrian Rue with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Progestin, Oral Contraceptive answer

Can you take Terminalia with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Progestin, Oral Contraceptive answer

Can you take Thunder God Vine with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Progestin, Oral Contraceptive answer

Can you take Tragacanth with Progestin, Oral Contraceptive?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Progestin, Oral Contraceptive answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Progestin, Oral Contraceptive is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Progestin, Oral Contraceptive, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Progestin, Oral Contraceptive sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Progestin, Oral Contraceptive through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Progestin, Oral Contraceptive through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Progestin, Oral Contraceptive through this category.

About Progestin, Oral Contraceptive

Progestin, Oral Contraceptive is a prescription medication also sold under the brand name Slynd. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Progestin, Oral Contraceptive  ·  Brand name: Slynd.

See the full Progestin-Only (drospirenone) Oral Contraceptives drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Progestin, Oral Contraceptive

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Progestin, Oral Contraceptive.

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Pharmacist Counseling Corner

Progestin, Oral Contraceptive & Supplements: Common Questions

What supplements interact with Progestin, Oral Contraceptive?
Our database currently documents 139 ingredients with a known Progestin, Oral Contraceptive interaction (3 major, 95 moderate, 41 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 139. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Progestin, Oral Contraceptive supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Progestin, Oral Contraceptive?
Plenty of supplements coexist fine with Progestin, Oral Contraceptive; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Slynd have the same supplement interactions as Progestin, Oral Contraceptive?
Yes — Slynd all contain Progestin, Oral Contraceptive, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Progestin, Oral Contraceptive and my other medications?
This page covers Progestin, Oral Contraceptive against supplements and herbal ingredients. Checking Progestin, Oral Contraceptive against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Progestin-Only (drospirenone) Oral Contraceptives drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.