Drug & supplement interaction

Pancreatic Enzyme Products + Cefprozil

Cefprozil brand name: Cefzil.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Pancreatic Enzyme Products and Cefprozil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pancreatic Enzyme Products and Cefprozil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefprozil and Pancreatic Enzyme Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pancreatic Enzyme Products safety at a glance

Pancreatic Enzyme... overall Use caution Generally well-tolerated when used correctly, but should be guided by a healthcare provider, especially for medical conditions.
Pregnancy Use caution May be used when clearly needed under medical supervision, but discuss with your doctor first.
Breastfeeding Use caution Little data exists, so use only under the guidance of your healthcare provider.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefprozil and Pancreatic Enzyme Products? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefprozil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefprozil is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Pancreatic Enzyme Products has documented interactions with 1 drug class — the most serious being acarbose (precose, prandase) (moderate) — and none of Cefprozil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pancreatic Enzyme Products Does Interact With Other Medications

Pancreatic Enzyme Products has 1 moderate known drug interaction in our database — Cefprozil isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Pancreatic Enzyme Products

Covers the 2,830 medications we’ve checked against Pancreatic Enzyme Products. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pancreatic Enzyme Products and Cefprozil May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Diarrhea / Vomiting / Nausea Additional detail

    Pancreatic Enzyme Products

    “Orally, prescription pancreatic enzyme products can cause abdominal pain, constipation, diarrhea, dry mouth, irritation of the skin around the mouth and anus, flatulence, nausea, steatorrhea, and vomiting. However, these symptoms can be controlled by following prescription dosing recommendations.”

    Pancreatic Enzyme Products · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 67617. Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed
    2. 67618. Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed
    3. 67645. Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI
    4. 67648. Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed
    5. 67651. Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76
    6. 67653. Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI

    Cefprozil

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefprozil. Read the label on DailyMed ›

Reported for Pancreatic Enzyme Products but not commonly for Cefprozil: mouth irritation or sores, an allergic reaction, a low white blood cell count and high blood sugar.

Effects for Cefprozil come from the ADVERSE REACTIONS section of its FDA label; effects for Pancreatic Enzyme Products come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 780 voluntary FDA FAERS reports for Cefprozil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Pancreatic Enzyme Products or Cefprozil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pancreatic Enzyme Products or Cefprozil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cefprozil

This page covers Pancreatic Enzyme Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefprozil page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefprozil page

“Cefprozil (Cefzil) is a cephalosporin antibiotic, usually a short course for ear, sinus, throat, or skin infections, and three of the 60 supplements on this list warrant real caution even for a week of pills. Activated charcoal can bind the drug and pull it out of your system before it works.”

Reviewed by 2 · Jul 18, 2026

Open the Cefprozil interaction page

One more smart check

Taking Pancreatic Enzyme Products as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Pancreatic Enzyme Products, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pancreatic Enzyme Products. Even though Pancreatic Enzyme Products itself has no known interaction with Cefprozil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pancreatic Enzyme Products and Cefprozil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pancreatic Enzyme Products
Steady interest

#1,447 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefprozil
Steady interest

#1,986 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pancreatic Enzyme Products reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pancreatic Enzyme Products and Cefprozil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pancreatic Enzyme Products

What is Pancreatic Enzyme Products?

  • Trouble digesting food (exocrine pancreatic insufficiency)
  • Cystic fibrosis
  • Chronic pancreatitis
  • After pancreas surgery or removal
  • Pancreatic cancer-related digestion problems
  • Bloating and gas (over-the-counter products)

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break down and absorb food. Prescription versions are well-proven and FDA-approved for conditions like cystic fibrosis and chronic pancreatitis, while over-the-counter 'pancreatin' supplements are not as tightly regulated. Always work with a doctor or pharmacist to get the right product and dose.

Pancreatic tissue (usually from pigs or cattle) · Capsules, delayed-release (enteric-coated) capsules, tablets, and powders

An interaction check asks whether these two react with each other — it does not ask whether Pancreatic Enzyme Products is a good idea for someone in your situation. Here is what our Pancreatic Enzyme Products record says about it on its own.

Pancreatic Enzyme Products: dosing

There is no single dose that fits everyone. Prescription pancreatic enzymes are dosed based on the amount of lipase units per meal, the person's body weight (especially in children), and how severe the enzyme shortage is. Your doctor will adjust the dose based on your symptoms, weight, and nutrition.In general, these products are taken with meals and snacks, often with the dose split so part is taken at the start of the meal. Enteric-coated capsules should usually be swallowed whole and not crushed or chewed.

From our Pancreatic Enzyme Products monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pancreatic Enzyme Products monograph & all interactions
Medication

About Cefprozil

What Is Cefprozil Used For?

Brand name: Cefzil

Cefprozil tablets and oral suspension are both used to treat mild to moderate bacterial infections in adults and children. Approved uses include pharyngitis/tonsillitis (strep throat), acute sinusitis, otitis media (ear infections), acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin and skin-structure infections.

Cefprozil tablets are also approved for secondary bacterial infection of acute bronchitis. Because antibiotic resistance is a real concern, cefprozil should only be used when the infection is proven or strongly suspected to be caused by bacteria that respond to it.

Most-Reported Side Effects for Cefprozil

From FAERS, the FDA’s public side-effect reporting system (780 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Chronic kidney disease 89 reports
Drug hypersensitivity 73 reports
Cough 64 reports
Acute kidney injury 59 reports
Dyspnea 59 reports
See full Cefprozil drug information
Keep checking

Other Drugs & Pancreatic Enzyme Products

Browse every other medication we’ve checked against Pancreatic Enzyme Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list
Evidence & sources

Pancreatic Enzyme Products References

The 40 references that drive our Pancreatic Enzyme Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. PubMed
  4. Bergner A, Bergner RK. Pulmonary hypersensitivity associated with pancreatin powder exposure. Pediatrics 1975;55:814-7. DOI
  5. Wiessmann KJ, Baur X. Occupational lung disease following long-term inhalation of pancreatic extracts. Eur J Respir Dis 1985;66:13-20.
  6. Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed
  7. Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed
  8. O'Keefe, S. J., Cariem, A. K., and Levy, M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol. 2001;32(4):319-323. PubMed
  9. Shin, S. Y., Hur, G. Y., Ye, Y. M., and Park, H. S. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci. 2008;23(2):347-349. PubMed
  10. Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI
  11. Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed
  12. Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76
  13. Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI
  14. Beverley, D. W., Kelleher, J., Macdonald, A., Littlewood, J. M., Robinson, T., and Walters, M. P. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis.Child 1987;62(6):564-568. PubMed
  15. Silber, W. Pankreoflat in benign diseases of the oesophagus: a blind therapeutic trial. S.Afr.Med J 7-7-1973;47(26):1137-1138.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pancreatic Enzyme Products and Cefprozil Together: Common Questions

Is it safe to take Pancreatic Enzyme Products with Cefprozil?
We do not list a known interaction between Pancreatic Enzyme Products and Cefprozil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Pancreatic Enzyme Products and Cefprozil have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Pancreatic Enzyme Products and Cefprozil combination checked?
Interactions in our licensed database are recorded against drug classes. Cefprozil is filed under 6 classifications, and Pancreatic Enzyme Products has documented interactions with 1 drug class — none of Cefprozil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pancreatic Enzyme Products interact with any other medications?
Yes. Pancreatic Enzyme Products has 1 documented drug interaction in our database — Cefprozil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefprozil interact with any supplements?
Yes. Cefprozil has documented interactions with 60 supplements in our database — Pancreatic Enzyme Products is not one of them. The Cefprozil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cefprozil and Pancreatic Enzyme Products?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.