Drug & supplement interaction

Pancreatic Enzyme Products + Vismodegib

Vismodegib brand name: Erivedge.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Pancreatic Enzyme Products and Vismodegib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Pancreatic Enzyme Products and Vismodegib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Vismodegib and Pancreatic Enzyme Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pancreatic Enzyme Products safety at a glance

Pancreatic Enzyme... overall Use caution Generally well-tolerated when used correctly, but should be guided by a healthcare provider, especially for medical conditions.

Pregnancy Use caution May be used when clearly needed under medical supervision, but discuss with your doctor first.

Breastfeeding Use caution Little data exists, so use only under the guidance of your healthcare provider.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Vismodegib and Pancreatic Enzyme Products? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Vismodegib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Vismodegib is filed under 4 classifications — including cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors, p-glycoprotein substrates. Pancreatic Enzyme Products has documented interactions with 1 drug class — the most serious being acarbose (precose, prandase) (moderate) — and none of Vismodegib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pancreatic Enzyme Products Does Interact With Other Medications

Pancreatic Enzyme Products has 1 moderate known drug interaction in our database — Vismodegib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Vismodegib)

Taking anything else?

Check Another of Your Medications Against Pancreatic Enzyme Products

Covers the 2,830 medications we’ve checked against Pancreatic Enzyme Products. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Pancreatic Enzyme Products and Vismodegib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Constipation / Diarrhea / Vomiting / Nausea Additional detail
Pancreatic Enzyme Products
“Orally, prescription pancreatic enzyme products can cause abdominal pain, constipation, diarrhea, dry mouth, irritation of the skin around the mouth and anus, flatulence, nausea, steatorrhea, and vomiting. However, these symptoms can be controlled by following prescription dosing recommendations.”

Pancreatic Enzyme Products · Natural Medicines adverse-effect record, reported in constipation.
6 sources cited

67617. Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed

67618. Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed

67645. Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI

67648. Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed

67651. Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76

67653. Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI
Vismodegib

Listed in the ADVERSE REACTIONS section of the FDA label for Vismodegib. Read the label on DailyMed ›

Reported for Pancreatic Enzyme Products but not commonly for Vismodegib: mouth irritation or sores, an allergic reaction, a low white blood cell count and stomach pain.

Effects for Vismodegib come from the ADVERSE REACTIONS section of its FDA label; effects for Pancreatic Enzyme Products come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Vismodegib

This page covers Pancreatic Enzyme Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Vismodegib page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 38 moderate · 17 minor.

From our pharmacist’s overview on the Vismodegib page

“St. John's wort can quietly undercut vismodegib (Erivedge), the pill for advanced basal cell carcinoma, by speeding up the gut pump that clears the drug from the body, and a cancer treatment that silently loses potency is the worst kind of interaction.”

Reviewed by 2 · Jul 18, 2026

Open the Vismodegib interaction page

One more smart check

Taking Pancreatic Enzyme Products as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Pancreatic Enzyme Products, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pancreatic Enzyme Products. Even though Pancreatic Enzyme Products itself has no known interaction with Vismodegib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pancreatic Enzyme Products and Vismodegib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pancreatic Enzyme Products

Steady interest

#911 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Vismodegib

Top half

#913 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pancreatic Enzyme Products reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pancreatic Enzyme Products and Vismodegib records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Pancreatic Enzyme Products

What is Pancreatic Enzyme Products?

Trouble digesting food (exocrine pancreatic insufficiency)
Cystic fibrosis
Chronic pancreatitis
After pancreas surgery or removal
Pancreatic cancer-related digestion problems
Bloating and gas (over-the-counter products)

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break down and absorb food. Prescription versions are well-proven and FDA-approved for conditions like cystic fibrosis and chronic pancreatitis, while over-the-counter 'pancreatin' supplements are not as tightly regulated. Always work with a doctor or pharmacist to get the right product and dose.

Pancreatic tissue (usually from pigs or cattle) · Capsules, delayed-release (enteric-coated) capsules, tablets, and powders

An interaction check asks whether these two react with each other — it does not ask whether Pancreatic Enzyme Products is a good idea for someone in your situation. Here is what our Pancreatic Enzyme Products record says about it on its own.

Pancreatic Enzyme Products: dosing

There is no single dose that fits everyone. Prescription pancreatic enzymes are dosed based on the amount of lipase units per meal, the person's body weight (especially in children), and how severe the enzyme shortage is. Your doctor will adjust the dose based on your symptoms, weight, and nutrition.In general, these products are taken with meals and snacks, often with the dose split so part is taken at the start of the meal. Enteric-coated capsules should usually be swallowed whole and not crushed or chewed.

From our Pancreatic Enzyme Products monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pancreatic Enzyme Products monograph & all interactions

Medication

About Vismodegib

What Is Vismodegib Used For?

Brand name: Erivedge

Erivedge (vismodegib) is used to treat adults with basal cell carcinoma — the most common type of skin cancer — in two specific situations: when the cancer has spread to other parts of the body (metastatic basal cell carcinoma), or when it is locally advanced and has returned after surgery, or when surgery and radiation are not options.

It is not approved for use in children.

Most-Reported Side Effects for Vismodegib

From FAERS, the FDA’s public side-effect reporting system (8,850 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Muscle spasms 2,065 reports

Alopecia 1,401 reports

Ageusia 1,011 reports

Fatigue 970 reports

Dysgeusia 747 reports

See full Vismodegib drug information

Keep checking

Other Drugs & Pancreatic Enzyme Products

Browse every other medication we’ve checked against Pancreatic Enzyme Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

1Moderate

0Minor

2,828No known interaction

1 Moderate 2,828 No interaction

Moderate

1 interaction

Acarbose ›

No interaction 2,828 drugs checked — show the list

We also checked Pancreatic Enzyme Products against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Pancreatic Enzyme Products list.

See the full Pancreatic Enzyme Products interactions page

See every supplement checked against Vismodegib, ranked by severity

Evidence & sources

Pancreatic Enzyme Products References

The 40 references that drive our Pancreatic Enzyme Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. PubMed
Bergner A, Bergner RK. Pulmonary hypersensitivity associated with pancreatin powder exposure. Pediatrics 1975;55:814-7. DOI
Wiessmann KJ, Baur X. Occupational lung disease following long-term inhalation of pancreatic extracts. Eur J Respir Dis 1985;66:13-20.
Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed
Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed
O'Keefe, S. J., Cariem, A. K., and Levy, M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol. 2001;32(4):319-323. PubMed
Shin, S. Y., Hur, G. Y., Ye, Y. M., and Park, H. S. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci. 2008;23(2):347-349. PubMed
Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI
Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed
Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76
Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI
Beverley, D. W., Kelleher, J., Macdonald, A., Littlewood, J. M., Robinson, T., and Walters, M. P. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis.Child 1987;62(6):564-568. PubMed
Silber, W. Pankreoflat in benign diseases of the oesophagus: a blind therapeutic trial. S.Afr.Med J 7-7-1973;47(26):1137-1138.
Sack, J., Blau, H., Goldfarb, D., Ben-Zaray, S., and Katznelson, D. Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel. Isr.J Med Sci. 1980;16(6):417-419.
Oades, P. J., Bush, A., Ong, P. S., and Brereton, R. J. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1-8-1994;343(8889):109. DOI
Mac Sweeney, E. J., Oades, P. J., Buchdahl, R., Rosenthal, M., and Bush, A. Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet 3-25-1995;345(8952):752-756. PubMed
Jones, R., Franklin, K., Spicer, R., and Berry, J. Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet 8-19-1995;346(8973):499. DOI
Taylor, C. J. and Steiner, G. M. Fibrosing colonopathy in a child on low-dose pancreatin. Lancet 10-21-1995;346(8982):1106-1107. PubMed
Ong, P. S., Oades, P. J., Bush, A., and Brereton, R. J. Colonic stricture in a boy with cystic fibrosis. Postgrad.Med J 1995;71(835):309-312. PubMed
Milla, C. E., Wielinski, C. L., and Warwick, W. J. High-strength pancreatic enzymes. Lancet 3-5-1994;343(8897):599. DOI
McHugh, K., Thomson, A., and Tam, P. Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis. Br.J Radiol. 1994;67(801):900-901. PubMed
Nouisa-Arvanitakis, S., Stapleton, F. B., Linshaw, M. A., and Kennedy, J. Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr 1977;90(2):302-305. PubMed
Lancellotti, L., Cabrini, G., Zanolla, L., and Mastella, G. High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. J Pediatr.Gastroenterol.Nutr. 1996;22(1):73-78. DOI
FitzSimmons, S. C., Burkhart, G. A., Borowitz, D., Grand, R. J., Hammerstrom, T., Durie, P. R., Lloyd-Still, J. D., and Lowenfels, A. B. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N.Engl.J Med 5-1- PubMed
Stapleton, F. B., Kennedy, J., Nousia-Arvanitakis, S., and Linshaw, M. A. Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N.Engl.J Med 7-29-1976;295(5):246-248. PubMed
Bruno, M. J., Haverkort, E. B., Tijssen, G. P., Tytgat, G. N., and van Leeuwen, D. J. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut 1998;42(1):92-96. PubMed
Miyoshi, H. and Kanzaki, T. Drug eruption (erythema multiforme type) due to a digestive enzyme drug. J Dermatol. 1998;25(1):28-31. PubMed
Chazalette, J. P. A Double-Blind Placebo-Controlled Trial of a Pancreatic Enzyme Formulation (Panzytrat 25 000) in the Treatment of Impaired Lipid Digestion in Patients with Cystic Fibrosis. Drug Investigation 1993;5(5):274. DOI
Seiler CM, Izbicki J, Varga-Szabó L, et al. Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a
Lee SK, Kim MS, Lee UH. Acute generalized exanthematous pustulosis induced by a digestive enzyme drug, Festal(®). Clin Exp Dermatol. 2018;43(3):321-323.
Whitcomb DC, Bodhani A, Beckmann K, et al. Efficacy and safety of pancrelipase/pancreatin in patients with exocrine pancreatic insufficiency and a medical history of diabetes mellitus. Pancreas. 2016;45(5):679-86. PubMed
Ramesh H, Reddy N, Bhatia S, et al. A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis. Pancre PubMed
Toskes PP, Secci A, Thieroff-Ekerdt R; ZENPEP Study Group. Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis. Pancreas. 2011;40(3):376-82. PubMed
Kahl S, Schütte K, Glasbrenner B, et al. The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study. JOP. 2014;15(2):165-74.
Trapnell BC, Maguiness K, Graff GR, Boyd D, Beckmann K, Caras S. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2009;8(6):370-7. PubMed
Carroccio A, Guarino A, Zuin G, et al. Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients. Aliment Pharmacol Ther. 2001;15(10):1619-25. PubMed
Guidance for Industry Exocrine Pancreatic Insufficiency Drug Products - Submitting NDAs. Available at: https://www.fda.gov/ucm/groups/fdagov-public/@fdagov-drugs-gen/documents/document/ucm071651.pdf. Accessed March 29, 2019.
Amoateng R, Hardman B, Liu C, Austin S. Rare case of pancrelipase therapy-induced neutropaenia. BMJ Case Rep 2021;14(3):e241799. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pancreatic Enzyme Products and Vismodegib Together: Common Questions

Is it safe to take Pancreatic Enzyme Products with Vismodegib?

We do not list a known interaction between Pancreatic Enzyme Products and Vismodegib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Pancreatic Enzyme Products and Vismodegib have any of the same side effects?

Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Pancreatic Enzyme Products and Vismodegib combination checked?

Interactions in our licensed database are recorded against drug classes. Vismodegib is filed under 4 classifications, and Pancreatic Enzyme Products has documented interactions with 1 drug class — none of Vismodegib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Pancreatic Enzyme Products interact with any other medications?

Yes. Pancreatic Enzyme Products has 1 documented drug interaction in our database — Vismodegib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Vismodegib interact with any supplements?

Yes. Vismodegib has documented interactions with 57 supplements in our database — Pancreatic Enzyme Products is not one of them. The Vismodegib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pancreatic Enzyme Products monograph Uses, safety profile, and every drug interaction in one place Vismodegib drug information The full plain-English guide to this medication Vismodegib supplement interactions Every supplement checked against Vismodegib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 40 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Vismodegib and Pancreatic Enzyme Products?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.