Drug & supplement interaction

Pao Pereira + Cisplatin

Cisplatin brand name: Platinol-AQ.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pao Pereira and Cisplatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pao Pereira and Cisplatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cisplatin and Pao Pereira in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pao Pereira at all — not against Cisplatin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pao Pereira safety at a glance

Pao Pereira overall Use caution Human safety data are limited, so use with care and professional guidance.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cisplatin and Pao Pereira? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Cisplatin’s Own FDA Label Lists

This is not an interaction — none of it involves Pao Pereira. These are the most notable effects listed in the ADVERSE REACTIONS section of Cisplatin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on
  • Loss of vision Worth acting on
  • Low magnesium Worth acting on
  • Hearing loss Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Dehydration Worth acting on
  • Low sodium Worth acting on
  • A low white blood cell count Worth acting on mentioned in 12.2% of FDA reports for Cisplatin
  • Low potassium Worth acting on
  • A heart attack Worth acting on

Showing the 10 most notable of 33 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cisplatin. Read the label on DailyMed › Where a percentage is shown, it is the share of 77,669 voluntary FDA FAERS reports for Cisplatin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pao Pereira’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pao Pereira side to compare — that is a limit of the record, not a statement that Pao Pereira has no side effects.

Overlapping uses

What Cisplatin Is Prescribed For, and What Pao Pereira Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Cisplatin is a prescription medicine with approved uses on its FDA label. Pao Pereira is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Cisplatin is prescribed for: Cisplatin Injection is used to treat three types of cancer. For metastatic testicular tumors and metastatic ovarian tumors, it is used as part of combination chemotherapy — alongside other approved cancer medicines — in patients who have already had surgery and/or radiation therapy. For metastatic ovarian tumors, it can also be used alone as a second-line treatment when standard chemotherapy has stopped working and cisplatin has not been tried before. For advanced bladder cancer (specifically transitional cell bladder cancer) that can no longer be treated with surgery or radiation, Cisplatin Injection is used as a single agent.

Pao Pereira has been studied for:

  • Cancer studied, not established Pao Pereira has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Pao Pereira for cancer

    Although there has been interest in using oral pao pereira for cancer, there is insufficient reliable information about the clinical effects of pao pereira for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cisplatin on your own; if you are taking Pao Pereira for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Cisplatin

This page covers Pao Pereira only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cisplatin page lists 90 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Acerola (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 75 moderate · 12 minor.

From our pharmacist’s overview on the Cisplatin page

“Kidney damage is the risk I would flag first for anyone receiving cisplatin (Platinol-AQ). Cisplatin is a chemotherapy drug that already stresses the kidneys, and two of the three major-rated interactions on this list, Siberian cocklebur and asarabacca, involve herbs that can injure the kidneys on their own, stacking harm on an organ t…”

Reviewed by 2 · Jul 18, 2026

Open the Cisplatin interaction page

One more smart check

Taking Pao Pereira as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Pao Pereira, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pao Pereira. Even though Pao Pereira itself has no known interaction with Cisplatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pao Pereira and Cisplatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pao Pereira
Steady interest

#1,155 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cisplatin
Steady interest

#1,598 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Pao Pereira is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pao Pereira reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pao Pereira and Cisplatin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pao Pereira

What is Pao Pereira?

  • Immune support
  • Cancer support (complementary use)
  • Antimalarial/fever (traditional)
  • Digestive complaints (traditional)
  • General tonic

Pao Pereira is a bark extract from a South American tree that is marketed mainly as a complementary cancer and immune-support supplement. Human evidence is very limited, and most research comes from laboratory and animal studies, so it should not be used in place of proven medical care. Talk with your pharmacist or doctor before trying it, especially if you have a serious health condition.

Geissospermum laeve · Apocynaceae · Bark (and bark extract) · Capsules, tinctures, liquid extracts, powdered bark

An interaction check asks whether these two react with each other — it does not ask whether Pao Pereira is a good idea for someone in your situation. Here is what our Pao Pereira record says about it on its own.

Pao Pereira: dosing

There is no established or standardized dose for Pao Pereira. Different products contain different amounts and strengths of bark extract.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Pao Pereira monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pao Pereira monograph & all interactions
Medication

About Cisplatin Injection

What Is Cisplatin Injection Used For?

Brand name: Platinol-AQ

Cisplatin Injection is used to treat three types of cancer. For metastatic testicular tumors and metastatic ovarian tumors, it is used as part of combination chemotherapy — alongside other approved cancer medicines — in patients who have already had surgery and/or radiation therapy. For metastatic ovarian tumors, it can also be used alone as a second-line treatment when standard chemotherapy has stopped working and cisplatin has not been tried before.

For advanced bladder cancer (specifically transitional cell bladder cancer) that can no longer be treated with surgery or radiation, Cisplatin Injection is used as a single agent.

Most-Reported Side Effects for Cisplatin

From FAERS, the FDA’s public side-effect reporting system (77,669 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 5,437 reports
Neutropenia 4,877 reports
Disease progression 4,657 reports
Febrile neutropenia 4,606 reports
Vomiting 4,566 reports
See full Cisplatin Injection drug information
Keep checking

Other Drugs & Pao Pereira

Browse every other medication we’ve checked against Pao Pereira — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pao Pereira against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pao Pereira list.

See the full Pao Pereira interactions page
See every supplement checked against Cisplatin, ranked by severity
Evidence & sources

Pao Pereira References

The 4 sources that drive our Pao Pereira monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Pao Pereira is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  4. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pao Pereira and Cisplatin Together: Common Questions

Is it safe to take Pao Pereira with Cisplatin?
We do not list a known interaction between Pao Pereira and Cisplatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Pao Pereira and Cisplatin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Pao Pereira in each. That is a conversation for your prescriber, especially if Cisplatin is being adjusted to a target.
Does Cisplatin interact with any supplements?
Yes. Cisplatin has documented interactions with 90 supplements in our database — Pao Pereira is not one of them. The Cisplatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pao Pereira monograph Uses, safety profile, and every drug interaction in one place Cisplatin Injection drug information The full plain-English guide to this medication Cisplatin supplement interactions Every supplement checked against Cisplatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cisplatin and Pao Pereira?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.