Medication interaction hub

What Supplements Interact with Cisplatin?

Cisplatin brand name: Platinol-AQ. Every interaction below applies to the brands too.

90 Interactions 3 Major 75 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cisplatin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cisplatin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Kidney damage is the risk I would flag first for anyone receiving cisplatin (Platinol-AQ). Cisplatin is a chemotherapy drug that already stresses the kidneys, and two of the three major-rated interactions on this list, Siberian cocklebur and asarabacca, involve herbs that can injure the kidneys on their own, stacking harm on an organ this treatment needs intact. The third major, activated charcoal, can bind medicines and lower the body's exposure to them. Of all the lists on this site, this one deserves genuine wariness.

Most of the remaining 87 entries, 75 of them rated moderate, follow two patterns. Fifty-three are immune-stimulating herbs and mushroom extracts that could push back against treatment, and a cluster of antioxidant supplements may dull the cell-killing effect the chemotherapy depends on. A few others change how oral medicines absorb, so any pills should be spaced well apart from charcoal-type products. Given the stakes, every supplement belongs on the oncology team's radar, beginning with anything that touches the kidneys.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 75 Minor 12 No known interaction 1,362

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cisplatin: Top Interactions at a Glance

The Cisplatin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 90 interacting ingredients — plus 1,362 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cisplatin Combinations Today

The Cisplatin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin C + Cisplatini

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Coenzyme Q10 + Cisplatini

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Acerola + Cisplatini

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Minor Likelihood Unlikely Asian Water Plantain + Cisplatini

Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does...

Read the full interaction Moderate Likelihood Possible Zinc + Cisplatini

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.

Read the full interaction Moderate Likelihood Possible Elderberry + Cisplatini

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.

Read the full interaction
The complete list

Every Supplement Checked Against Cisplatin

All 1,452 ingredients in our database, ranked by severity — 90 with a Cisplatin interaction on file and 1,362 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cisplatin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Cisplatin answer

Can you take Coenzyme Q10 with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Cisplatin answer

Can you take Acerola with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Cisplatin answer

Can you take Asian Water Plantain with Cisplatin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Cisplatin answer

Can you take Zinc with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zinc might interfere with the therapeutic effects of cisplatin.

Full Zinc + Cisplatin answer

Can you take Melatonin with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might interfere with immunosuppressive therapy.

Full Melatonin + Cisplatin answer

Can you take Mountain Ash with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Cisplatin answer

Can you take Neem with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem might decrease the effectiveness of immunosuppressants.

Full Neem + Cisplatin answer

Can you take Panax Ginseng with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng use might interfere with immunosuppressive therapy.

Full Panax Ginseng + Cisplatin answer

Can you take Picrorhiza with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Picrorhiza seems to have immunostimulating activity.

Full Picrorhiza + Cisplatin answer

Can you take Quillaia with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Full Quillaia + Cisplatin answer

Can you take Rhodiola with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Full Rhodiola + Cisplatin answer

Can you take Rhubarb with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Cisplatin answer

Can you take Rice Bran Arabinoxylan Compound with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Full Rice Bran Arabinoxylan Compound + Cisplatin answer

Can you take Rose Hip with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative d...

Full Rose Hip + Cisplatin answer

Can you take Selenium with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.

Full Selenium + Cisplatin answer

Can you take Shark Cartilage with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shark cartilage might interfere with immunosuppressive therapy.

Full Shark Cartilage + Cisplatin answer

Can you take Shiitake Mushroom with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Full Shiitake Mushroom + Cisplatin answer

Can you take Slippery Elm with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Cisplatin answer

Can you take Sodium Bicarbonate with Cisplatin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients receiving cisplatin.

Full Sodium Bicarbonate + Cisplatin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cisplatin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cisplatin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cisplatin sits in 6 interaction categories. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Cisplatin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Cisplatin through this category.

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Cisplatin through this category.

Cisplatin (Platinol-Aq) 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cisplatin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cisplatin through this category.

Platinum Agents 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Cisplatin through this category.

About Cisplatin

Cisplatin Injection is a platinum-based chemotherapy given intravenously to treat metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer.

Generic name: Cisplatin  ·  Brand name: Platinol-AQ.

See the full Cisplatin Injection drug information

Related: does Cisplatin deplete any nutrients?

Cisplatin has 6 reported nutrient associations in the research literature — see the Cisplatin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cisplatin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cisplatin.

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Pharmacist Counseling Corner

Cisplatin & Supplements: Common Questions

What supplements interact with Cisplatin?
More than you might expect — 90 in total, though they are far from equal: 3 are rated major, 75 moderate, and 12 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Asarabacca.
Which Cisplatin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Cisplatin?
Usually yes — most people on Cisplatin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Platinol-AQ have the same supplement interactions as Cisplatin?
Yes — Platinol-AQ all contain Cisplatin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Cisplatin deplete any vitamins or nutrients?
It might — Cisplatin has 6 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Cisplatin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Cisplatin and my other medications?
This page covers Cisplatin against supplements and herbal ingredients. Checking Cisplatin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cisplatin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.