Drug & supplement interaction

Para-aminobenzoic Acid (paba) + Ifosfamide

Ifosfamide brand name: Ifex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Para-aminobenzoic Acid (paba) and Ifosfamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Para-aminobenzoic Acid (paba) and Ifosfamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ifosfamide and Para-aminobenzoic Acid (paba) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Para-aminobenzoic Acid (paba) safety at a glance

Para-aminobenzoic... overall Use caution Generally tolerated at low doses, but high doses may cause stomach upset and rare liver or other problems.
Pregnancy Likely Safe When used topically and appropriately. There is insufficient reliable information available about the safety of the oral use of PABA during pregnancy and breast... Read the full pregnancy detail
Breastfeeding Likely Safe When used topically and appropriately. There is insufficient reliable information available about the safety of the oral use of PABA during pregnancy and breast... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ifosfamide and Para-aminobenzoic Acid (paba)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ifosfamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ifosfamide is filed under 4 classifications — including alkylating agents, nephrotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Para-aminobenzoic Acid (paba) has documented interactions with 2 drug classes — the most serious being dapsone (avlosulfon) (major) and sulfonamide antibiotics (major) — and none of Ifosfamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Para-aminobenzoic Acid (paba) Does Interact With Other Medications

Para-aminobenzoic Acid (paba) has 17 major, known drug interactions in our database — Ifosfamide isn’t one of them. If you take anything else, check it against the full list below.

Major 17 No known interaction 2,813 (incl. Ifosfamide)
Taking anything else?

Check Another of Your Medications Against Para-aminobenzoic Acid (paba)

Covers the 2,830 medications we’ve checked against Para-aminobenzoic Acid (paba). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Para-aminobenzoic Acid (paba) and Ifosfamide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Nausea Additional detail

    Para-aminobenzoic Acid (paba)

    “Orally, the most commonly reported side effects of PABA are diarrhea, nausea, vomiting, anorexia, dyspepsia, fever, and rash. PABA should be discontinued if adverse effects prevent the patient from eating (10). In one report, up to 25% of patients discontinued PABA due to intolerance of side effects.”

    Para-aminobenzoic Acid (paba) · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 1074. Clegg DO, Reading JC, Mayes MD, et al. Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma. J Rheumatol 1994;21:105-10.
    2. 10. United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.

    Ifosfamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Ifosfamide. Read the label on DailyMed ›

Reported for Para-aminobenzoic Acid (paba) but not commonly for Ifosfamide: an allergic reaction, sun sensitivity, liver problems and a skin rash.

Effects for Ifosfamide come from the ADVERSE REACTIONS section of its FDA label; effects for Para-aminobenzoic Acid (paba) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 21,360 voluntary FDA FAERS reports for Ifosfamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Para-aminobenzoic Acid (paba) in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used topically and appropriately. There is insufficient reliable information available about the safety of the oral use of PABA during pregnancy and breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ifosfamide

This page covers Para-aminobenzoic Acid (paba) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ifosfamide page lists 149 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 5 major · 102 moderate · 42 minor.

From our pharmacist’s overview on the Ifosfamide page

“Grapefruit is the first thing I would take off the table during ifosfamide (Ifex) treatment, and this list as a whole deserves careful attention rather than a quick skim. Ifosfamide is chemotherapy, and the body activates it through the CYP3A4 enzyme, so supplements that block or speed up that enzyme can shift how much active drug you…”

Reviewed by 2 · Jul 18, 2026

Open the Ifosfamide interaction page

How much people look this up

Where Para-aminobenzoic Acid (paba) and Ifosfamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Para-aminobenzoic Acid (paba)
Steady interest

#1,439 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ifosfamide
Steady interest

#1,422 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Para-aminobenzoic Acid (paba) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Para-aminobenzoic Acid (paba) and Ifosfamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Para-aminobenzoic Acid (paba)

What is Para-aminobenzoic Acid (paba)?

  • Skin conditions like vitiligo
  • Scleroderma and skin tightening conditions
  • Graying hair
  • Sunscreen ingredient (older topical products)
  • General supplement and 'B-complex' support

PABA (para-aminobenzoic acid) is a chemical sometimes taken as a supplement or used in older sunscreens. Evidence supporting its oral use for skin conditions, hair color, and other claims is limited and outdated, and high doses can cause side effects. Talk with your pharmacist or doctor before using it.

Not a plant; PABA is a chemical compound (an amino acid-like substance) · Tablets, capsules, and topical creams or lotions

An interaction check asks whether these two react with each other — it does not ask whether Para-aminobenzoic Acid (paba) is a good idea for someone in your situation. Here is what our Para-aminobenzoic Acid (paba) record says about it on its own.

Para-aminobenzoic Acid (paba): dosing

There is no well-established standard dose of PABA for any condition, and high doses have been associated with toxicity. Some older studies used relatively large amounts under medical supervision, but these are not appropriate for routine self-treatment.If you choose to use a PABA product, follow the directions on the label and do not exceed the recommended amount.

From our Para-aminobenzoic Acid (paba) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Para-aminobenzoic Acid (paba) monograph & all interactions
Medication

About Ifosfamide Injection

What Is Ifosfamide Injection Used For?

Brand name: Ifex

Ifosfamide Injection (brands: Ifex, IFOSFAMIDE) is indicated for use in combination with certain other approved cancer medicines as third-line chemotherapy for germ cell testicular cancer. It is always given alongside mesna, a protective drug that helps prevent serious bladder bleeding.

Most-Reported Side Effects for Ifosfamide

From FAERS, the FDA’s public side-effect reporting system (21,360 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 2,701 reports
Disease progression 2,122 reports
Neutropenia 1,905 reports
Thrombocytopenia 1,548 reports
Anemia 1,258 reports
See full Ifosfamide Injection drug information
Keep checking

Other Drugs & Para-aminobenzoic Acid (paba)

Browse every other medication we’ve checked against Para-aminobenzoic Acid (paba) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

17Major
0Moderate
0Minor
2,812No known interaction
17 Major 2,812 No interaction
Major

17 interactions

No interaction 2,812 drugs checked — show the list

We also checked Para-aminobenzoic Acid (paba) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,812 medications checked with no known interaction — see the full Para-aminobenzoic Acid (paba) list.

See the full Para-aminobenzoic Acid (paba) interactions page
See every supplement checked against Ifosfamide, ranked by severity
Evidence & sources

Para-aminobenzoic Acid (paba) References

The 11 references that drive our Para-aminobenzoic Acid (paba) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.
  2. Facts and Comparisons staff. Drug Facts and Comparisons. St Louis: Wolters Kluwer Company (updated monthly).
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Worobec S, LaChine A. Dangers of orally administered para-aminobenzoic acid. JAMA 1984;251:2348. DOI
  5. Zarafonetis CJ, Dabich L, DeVol EB, et al. Potassium para-aminobenzoate and liver function test findings. J Am Acad Dermatol 1986;15:144-9. PubMed
  6. Clegg DO, Reading JC, Mayes MD, et al. Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma. J Rheumatol 1994;21:105-10.
  7. Ludwig G. Evaluation of conservative therapeutic approaches to Peyronie's disease (fibrotic induration of the penis). Urol Int 1991;47:236-9. PubMed
  8. Kantor GR, Ratz JL. Liver toxicity from potassium para-aminobenzoate. J Am Acad Dermatol 1985;13:671-2. PubMed
  9. Wiesel LL, Barritt AS, Stumpe WM. The synergistic action of para-aminobenzoic acid and cortisone in the treatment of rheumatoid arthritis. Am J Med Sci 1951;243-8. DOI
  10. Taylor, S. E. and Dorris, R. L. Modification of local anesthetic toxicity by vasoconstrictors. Anesth.Prog 1989;36(3):79-87.
  11. Davies, D. M. and Cavanagh, J. Jaundice from potassium p-aminobenzoate. Lancet 4-22-1967;1(7495):896. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Para-aminobenzoic Acid (paba) and Ifosfamide Together: Common Questions

Is it safe to take Para-aminobenzoic Acid (paba) with Ifosfamide?
We do not list a known interaction between Para-aminobenzoic Acid (paba) and Ifosfamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Para-aminobenzoic Acid (paba) and Ifosfamide have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Para-aminobenzoic Acid (paba) and Ifosfamide combination checked?
Interactions in our licensed database are recorded against drug classes. Ifosfamide is filed under 4 classifications, and Para-aminobenzoic Acid (paba) has documented interactions with 2 drug classes — none of Ifosfamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Para-aminobenzoic Acid (paba) interact with any other medications?
Yes. Para-aminobenzoic Acid (paba) has 17 documented drug interactions in our database — Ifosfamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ifosfamide interact with any supplements?
Yes. Ifosfamide has documented interactions with 149 supplements in our database — Para-aminobenzoic Acid (paba) is not one of them. The Ifosfamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Para-aminobenzoic Acid (paba) monograph Uses, safety profile, and every drug interaction in one place Ifosfamide Injection drug information The full plain-English guide to this medication Ifosfamide supplement interactions Every supplement checked against Ifosfamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ifosfamide and Para-aminobenzoic Acid (paba)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.