Drug & supplement interaction

Pareira + Ondansetron

Ondansetron brand name: Zofran.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pareira and Ondansetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Pareira and Ondansetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ondansetron and Pareira in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Pareira at all — not against Ondansetron, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pareira safety at a glance

Pareira overall Use caution Human safety data are limited and related plants contain potent alkaloids, so use cautiously.
Pregnancy Unsafe When used orally. Pareira may promote menstruation. Read the full pregnancy detail
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ondansetron and Pareira? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ondansetron’s Own FDA Label Lists

This is not an interaction — none of it involves Pareira. These are the most notable effects listed in the ADVERSE REACTIONS section of Ondansetron’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • An irregular heartbeat Worth acting on
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Migraine
  • A fast or pounding heartbeat
  • Numbness or tingling

From the ADVERSE REACTIONS section of the FDA label for Ondansetron. Read the label on DailyMed › Where a percentage is shown, it is the share of 121,840 voluntary FDA FAERS reports for Ondansetron that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Pareira’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pareira side to compare — that is a limit of the record, not a statement that Pareira has no side effects.

Special populations

Pareira in Pregnancy & Breastfeeding

Pregnancy Unsafe

When used orally. Pareira may promote menstruation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Pareira or Ondansetron

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pareira or Ondansetron, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ondansetron

This page covers Pareira only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ondansetron page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 145 moderate · 46 minor.

From our pharmacist’s overview on the Ondansetron page

“Ondansetron (Zofran) often stands between you and relentless nausea from chemotherapy or surgery, so read this page carefully. Four of the 195 ingredients rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Ondansetron interaction page

How much people look this up

Where Pareira and Ondansetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pareira
Steady interest

#1,193 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ondansetron
Steady interest

#1,687 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pareira reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pareira and Ondansetron records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pareira

What is Pareira?

  • Urinary tract complaints
  • Bladder irritation and inflammation
  • Kidney stones
  • Fluid retention (diuretic use)
  • Digestive upset

Pareira is a traditional plant remedy, mainly from the South American vine Chondrodendron tomentosum, that has long been used for urinary and bladder complaints. Modern scientific evidence in humans is very limited, and some related plants in this group contain powerful muscle-relaxing compounds, so it should be used cautiously and only under professional guidance.

Chondrodendron tomentosum · Menispermaceae · Root and woody stem (bark) · Dried root, tincture, fluid extract, homeopathic preparations

An interaction check asks whether these two react with each other — it does not ask whether Pareira is a good idea for someone in your situation. Here is what our Pareira record says about it on its own.

Pareira: dosing

There is no established standardized dose for pareira, and products vary widely in strength and form. Because of this, it is not possible to recommend a specific safe and effective amount.If you choose to use a pareira product, follow the directions on the label and do not exceed the recommended amount.

From our Pareira monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pareira monograph & all interactions
Medication

About Ondansetron

What Is Ondansetron Used For?

Brand name: Zofran

Ondansetron is used to prevent nausea and vomiting in several situations. Oral forms (tablets, orally disintegrating tablets, and oral solution) are approved to prevent nausea and vomiting from highly or moderately emetogenic (nausea-causing) cancer chemotherapy, from radiation therapy to the abdomen or whole body, and from surgery.

Ondansetron injection (given intravenously or intramuscularly in a clinical setting) is approved to prevent nausea and vomiting from emetogenic cancer chemotherapy — including high-dose cisplatin — in adults and children as young as 6 months old, as well as to prevent postoperative nausea and vomiting.

Most-Reported Side Effects for Ondansetron

From FAERS, the FDA’s public side-effect reporting system (121,840 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 14,459 reports
Fatigue 10,275 reports
Diarrhea 9,488 reports
Vomiting 8,777 reports
Dyspnea 5,971 reports
See full Ondansetron drug information
Keep checking

Other Drugs & Pareira

Browse every other medication we’ve checked against Pareira — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Pareira against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pareira list.

See the full Pareira interactions page
See every supplement checked against Ondansetron, ranked by severity
Evidence & sources

Pareira References

The 1 references that drive our Pareira monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pareira and Ondansetron Together: Common Questions

Is it safe to take Pareira with Ondansetron?
We do not list a known interaction between Pareira and Ondansetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ondansetron interact with any supplements?
Yes. Ondansetron has documented interactions with 195 supplements in our database — Pareira is not one of them. The Ondansetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pareira monograph Uses, safety profile, and every drug interaction in one place Ondansetron drug information The full plain-English guide to this medication Ondansetron supplement interactions Every supplement checked against Ondansetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ondansetron and Pareira?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.