Perilla + Epirubicin
Epirubicin brand name: Ellence.
We found no known interaction between Perilla and Epirubicin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Perilla and Epirubicin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Epirubicin and Perilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Perilla at all — not against Epirubicin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Perilla safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Epirubicin Is Prescribed For, and What Perilla Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Epirubicin is a prescription medicine with approved uses on its FDA label. Perilla is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Epirubicin is prescribed for: Ellence (epirubicin), given as an intravenous injection, is used as part of adjuvant (post-surgery) combination chemotherapy in patients with breast cancer who have evidence of tumor involvement in the axillary lymph nodes (lymph nodes under the arm) following surgical removal of the primary tumor. It is not used alone — Ellence is always given as part of a multi-drug regimen alongside other chemotherapy agents.
Perilla has been studied for:
-
Cancer studied, not established Perilla has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Perilla for cancer
Although there has been interest in using oral perilla for cancer, there is insufficient reliable information about the clinical effects of perilla for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Epirubicin on your own; if you are taking Perilla for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Epirubicin
This page covers Perilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Epirubicin page lists 24 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).
By severity: 1 major · 14 moderate · 9 minor.
From our pharmacist’s overview on the Epirubicin page
“Epirubicin (Ellence) is chemotherapy, most often used for breast cancer, and when a supplement can weaken the treatment itself, the 24 ingredients on this list deserve real caution. The lone major entry is activated charcoal, which can pull the drug back out of the body even though epirubicin is given by IV, since the medicine recircul…”
Reviewed by 2 · Jul 18, 2026
Taking Perilla as Part of a Dietary Supplement Product? Check It for Interactions
We hold 199 real supplement products containing Perilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Perilla. Even though Perilla itself has no known interaction with Epirubicin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Perilla and Epirubicin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,005 of 1,452 supplements looked up here in the last 7 days
#1,083 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perilla reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Perilla and Epirubicin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Perilla
What is Perilla?
- Seasonal and food allergies
- Asthma and airway inflammation
- Atopic dermatitis (eczema)
- Digestive upset
- General anti-inflammatory support
Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it should not replace proven treatments. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.
Perilla frutescens · Lamiaceae · Leaves, seeds, stem, and seed oil · Tea, capsules, seed oil, essential oil, dried leaf, culinary herb
An interaction check asks whether these two react with each other — it does not ask whether Perilla is a good idea for someone in your situation. Here is what our Perilla record says about it on its own.
Perilla: dosing
There is no well-established standard dose for perilla supplements. Products vary widely in their form and strength, from leaf teas to seed oil softgels to standardized extracts.The safest approach is to follow the directions on the product label and not to exceed them.
From our Perilla monograph — the full record covers uses, side effects and every documented interaction.
About Epirubicin
What Is Epirubicin Used For?
Brand name: Ellence
Ellence (epirubicin), given as an intravenous injection, is used as part of adjuvant (post-surgery) combination chemotherapy in patients with breast cancer who have evidence of tumor involvement in the axillary lymph nodes (lymph nodes under the arm) following surgical removal of the primary tumor.
It is not used alone — Ellence is always given as part of a multi-drug regimen alongside other chemotherapy agents.
Other Drugs & Perilla
Browse every other medication we’ve checked against Perilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Perilla against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perilla list.
Perilla References
The 4 references that drive our Perilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
- Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
- Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Perilla and Epirubicin Together: Common Questions
Is it safe to take Perilla with Epirubicin?
Do Perilla and Epirubicin have any of the same side effects?
Are Perilla and Epirubicin used for the same thing?
Does Epirubicin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Epirubicin and Perilla?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.