Drug & supplement interaction

Perilla + Nivolumab, Relatlimab-rmbw

Nivolumab, Relatlimab-rmbw brand name: Opdualag.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Perilla and Nivolumab, Relatlimab-rmbw in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Perilla and Nivolumab, Relatlimab-rmbw

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nivolumab, Relatlimab-rmbw and Perilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Perilla at all — not against Nivolumab, Relatlimab-rmbw, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Perilla safety at a glance

Perilla overall Use caution Generally well tolerated as a food, but supplement-strength products are not well studied.
Pregnancy Avoid Not enough safety data; avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid medicinal amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nivolumab, Relatlimab-rmbw and Perilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Perilla and Nivolumab, Relatlimab-rmbw May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Perilla

    “Topically, perilla may cause contact dermatitis (6,68664,94313).”

    Perilla · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 68664. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
    3. 94313. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed

    Nivolumab, Relatlimab-rmbw

    Listed in the ADVERSE REACTIONS section of the FDA label for Nivolumab, Relatlimab-rmbw. Read the label on DailyMed ›

Reported for Perilla but not commonly for Nivolumab, Relatlimab-rmbw: a severe allergic reaction and wheezing.

Effects for Nivolumab, Relatlimab-rmbw come from the ADVERSE REACTIONS section of its FDA label; effects for Perilla come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Nivolumab, Relatlimab-rmbw Is Prescribed For, and What Perilla Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Nivolumab, Relatlimab-rmbw is a prescription medicine with approved uses on its FDA label. Perilla is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Nivolumab, Relatlimab-rmbw is prescribed for: Opdualag is approved to treat unresectable or metastatic melanoma — melanoma that cannot be surgically removed or has spread to other parts of the body. It is approved for adults and for pediatric patients 12 years of age or older who weigh at least 40 kg (about 88 lbs). A safe and effective dose for patients younger than 12, or for those 12 and older who weigh less than 40 kg, has not been established.

Perilla has been studied for:

  • Cancer studied, not established Perilla has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Perilla for cancer

    Although there has been interest in using oral perilla for cancer, there is insufficient reliable information about the clinical effects of perilla for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Nivolumab, Relatlimab-rmbw on your own; if you are taking Perilla for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Perilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 199 real supplement products containing Perilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Perilla. Even though Perilla itself has no known interaction with Nivolumab, Relatlimab-rmbw, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Perilla and Nivolumab, Relatlimab-rmbw Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Perilla
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nivolumab, Relatlimab-rmbw
Steady interest

#1,615 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Perilla and Nivolumab, Relatlimab-rmbw records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Perilla

What is Perilla?

Perilla
  • Seasonal and food allergies
  • Asthma and airway inflammation
  • Atopic dermatitis (eczema)
  • Digestive upset
  • General anti-inflammatory support

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it should not replace proven treatments. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Perilla frutescens · Lamiaceae · Leaves, seeds, stem, and seed oil · Tea, capsules, seed oil, essential oil, dried leaf, culinary herb

An interaction check asks whether these two react with each other — it does not ask whether Perilla is a good idea for someone in your situation. Here is what our Perilla record says about it on its own.

Perilla: dosing

There is no well-established standard dose for perilla supplements. Products vary widely in their form and strength, from leaf teas to seed oil softgels to standardized extracts.The safest approach is to follow the directions on the product label and not to exceed them.

From our Perilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Perilla monograph & all interactions
Medication

About Nivolumab and relatlimab-rmbw

What Is Nivolumab and relatlimab-rmbw Used For?

Brand name: Opdualag

Opdualag is approved to treat unresectable or metastatic melanoma — melanoma that cannot be surgically removed or has spread to other parts of the body. It is approved for adults and for pediatric patients 12 years of age or older who weigh at least 40 kg (about 88 lbs).

A safe and effective dose for patients younger than 12, or for those 12 and older who weigh less than 40 kg, has not been established.

See full Nivolumab and relatlimab-rmbw drug information
Keep checking

Other Drugs & Perilla

Browse every other medication we’ve checked against Perilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Perilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perilla list.

See the full Perilla interactions page
See every supplement checked against Nivolumab, Relatlimab-rmbw, ranked by severity
Evidence & sources

Perilla References

The 4 references that drive our Perilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Perilla and Nivolumab, Relatlimab-rmbw Together: Common Questions

Is it safe to take Perilla with Nivolumab, Relatlimab-rmbw?
We do not list a known interaction between Perilla and Nivolumab, Relatlimab-rmbw. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Perilla and Nivolumab, Relatlimab-rmbw have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Perilla and Nivolumab, Relatlimab-rmbw used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Perilla in each. That is a conversation for your prescriber, especially if Nivolumab, Relatlimab-rmbw is being adjusted to a target.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Perilla monograph Uses, safety profile, and every drug interaction in one place Nivolumab and relatlimab-rmbw drug information The full plain-English guide to this medication Nivolumab, Relatlimab-rmbw supplement interactions Every supplement checked against Nivolumab, Relatlimab-rmbw, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nivolumab, Relatlimab-rmbw and Perilla?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.