Perilla + Raltegravir
Raltegravir brand name: Isentress.
We found no known interaction between Perilla and Raltegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Perilla and Raltegravir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Raltegravir and Perilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Perilla at all — not against Raltegravir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Perilla safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Raltegravir Is Prescribed For, and What Perilla Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Raltegravir is a prescription medicine with approved uses on its FDA label. Perilla is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Raltegravir is prescribed for: Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own. Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.
Perilla has been studied for:
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Cancer studied, not established Perilla has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Perilla for cancer
Although there has been interest in using oral perilla for cancer, there is insufficient reliable information about the clinical effects of perilla for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Raltegravir on your own; if you are taking Perilla for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Raltegravir
This page covers Perilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Raltegravir page lists 33 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate) and Calcium (moderate).
By severity: 1 major · 22 moderate · 10 minor.
From our pharmacist’s overview on the Raltegravir page
“For someone taking raltegravir (Isentress) to keep HIV suppressed, a steady drug level is what blocks rebound and resistance, and this list deserves genuine vigilance. The lone major-rated entry is activated charcoal, which can soak up the medicine in the gut and cut what reaches your blood.”
Reviewed by 2 · Jul 18, 2026
Taking Perilla as Part of a Dietary Supplement Product? Check It for Interactions
We hold 199 real supplement products containing Perilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Perilla. Even though Perilla itself has no known interaction with Raltegravir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Perilla and Raltegravir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#514 of 1,452 supplements looked up here in the last 7 days
#2,030 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Perilla reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Perilla and Raltegravir records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Perilla
What is Perilla?
- Seasonal and food allergies
- Asthma and airway inflammation
- Atopic dermatitis (eczema)
- Digestive upset
- General anti-inflammatory support
Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it should not replace proven treatments. It is generally well tolerated as a food, but talk with your pharmacist or doctor before using concentrated supplements.
Perilla frutescens · Lamiaceae · Leaves, seeds, stem, and seed oil · Tea, capsules, seed oil, essential oil, dried leaf, culinary herb
An interaction check asks whether these two react with each other — it does not ask whether Perilla is a good idea for someone in your situation. Here is what our Perilla record says about it on its own.
Perilla: dosing
There is no well-established standard dose for perilla supplements. Products vary widely in their form and strength, from leaf teas to seed oil softgels to standardized extracts.The safest approach is to follow the directions on the product label and not to exceed them.
From our Perilla monograph — the full record covers uses, side effects and every documented interaction.
About Raltegravir
What Is Raltegravir Used For?
Brand name: Isentress
Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own.
Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.
Most-Reported Side Effects for Raltegravir
From FAERS, the FDA’s public side-effect reporting system (16,418 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Perilla
Browse every other medication we’ve checked against Perilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Perilla against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Perilla list.
Perilla References
The 4 references that drive our Perilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
- Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
- Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Perilla and Raltegravir Together: Common Questions
Is it safe to take Perilla with Raltegravir?
Are Perilla and Raltegravir used for the same thing?
Does Raltegravir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.