Phytase + Glecaprevir, Pibrentasvir
Glecaprevir, Pibrentasvir brand name: Mavyret.
We found no known interaction between Phytase and Glecaprevir, Pibrentasvir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glecaprevir, Pibrentasvir states a food rule worth keeping to.
Phytase and Glecaprevir, Pibrentasvir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Glecaprevir, Pibrentasvir and Phytase in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Phytase at all — not against Glecaprevir, Pibrentasvir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Phytase safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Glecaprevir, Pibrentasvir Products Have a Food Rule — Phytase Should Not Break It
At least one FDA label for a product containing Glecaprevir, Pibrentasvir says to take it with food. If you take Phytase on an empty stomach out of habit, keep them separate — and take Glecaprevir, Pibrentasvir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glecaprevir, Pibrentasvir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Recommended dosage in adults: Three tablets taken at the same time orally once daily (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) with food.
From the Dosage and Administration section of the FDA label we read for Glecaprevir, Pibrentasvir — where that label names a specific product, the instruction is that product's. See the Glecaprevir, Pibrentasvir drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Glecaprevir, Pibrentasvir
This page covers Phytase only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glecaprevir, Pibrentasvir page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 103 moderate · 38 minor.
From our pharmacist’s overview on the Glecaprevir, Pibrentasvir page
“Mavyret (glecaprevir and pibrentasvir) is a short course of pills meant to cure hepatitis C, so I read its supplement list with real caution. Nearly everything on it can shift how much of the drug reaches your blood, mostly through the CYP3A4 enzyme or the P-glycoprotein transporter that handles it.”
Reviewed by 2 · Jul 18, 2026
Taking Phytase as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,063 real supplement products containing Phytase, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phytase. Even though Phytase itself has no known interaction with Glecaprevir, Pibrentasvir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Phytase and Glecaprevir, Pibrentasvir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#251 of 1,452 supplements looked up here in the last 7 days
#395 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phytase reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phytase and Glecaprevir, Pibrentasvir records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Phytase
What is Phytase?
- Improving mineral absorption
- Breaking down phytic acid (phytate) in grains and legumes
- Supporting digestion of plant-based foods
- Reducing 'anti-nutrient' effects of high-phytate diets
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used in animal feed and food processing, but human supplement research is limited, so talk to a pharmacist or doctor before using it.
Enzyme (often derived from fungi, bacteria, or plants such as wheat and rice bran) · Capsules, tablets, powder, and as an added ingredient in some digestive enzyme blends
An interaction check asks whether these two react with each other — it does not ask whether Phytase is a good idea for someone in your situation. Here is what our Phytase record says about it on its own.
Phytase: dosing
There is no established standard dose of phytase for people. Phytase activity is often measured in special enzyme units (sometimes listed as "FTU" or "phytase units") rather than simple milligrams, and products vary widely.Because of this, the best approach is to follow the directions on the product label and not exceed them.
From our Phytase monograph — the full record covers uses, side effects and every documented interaction.
About Glecaprevir and Pibrentasvir
What Is Glecaprevir and Pibrentasvir Used For?
Brand name: Mavyret
Mavyret treats acute or chronic hepatitis C virus (HCV) infection caused by genotypes 1, 2, 3, 4, 5, or 6 in adults and children 3 years and older who have no cirrhosis or have compensated cirrhosis (mild liver scarring that is still functioning).
Mavyret is also approved for adults and children 3 years and older with genotype 1 HCV who were previously treated with either an NS5A inhibitor or an NS3/4A protease inhibitor (two earlier classes of hepatitis C drugs) — but not both at the same time.
Other Drugs & Phytase
Browse every other medication we’ve checked against Phytase — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Phytase against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Rosuvastatin ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Methotrexate ›
- Isotretinoin ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Bendamustine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Quetiapine ›
- Naproxen ›
- Clonazepam ›
- Acetaminophen, Codeine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Phytase list.
Phytase References
The 7 references that drive our Phytase monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Phytase and Glecaprevir, Pibrentasvir Together: Common Questions
Is it safe to take Phytase with Glecaprevir, Pibrentasvir?
Should I take Phytase and Glecaprevir, Pibrentasvir at the same time of day?
Does Glecaprevir, Pibrentasvir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.