Medication interaction hub

What Supplements Interact with Glecaprevir, Pibrentasvir?

Glecaprevir, Pibrentasvir brand name: Mavyret. Every interaction below applies to the brands too.

144 Interactions 3 Major 103 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glecaprevir, Pibrentasvir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glecaprevir, Pibrentasvir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mavyret (glecaprevir and pibrentasvir) is a short course of pills meant to cure hepatitis C, so I read its supplement list with real caution. Nearly everything on it can shift how much of the drug reaches your blood, mostly through the CYP3A4 enzyme or the P-glycoprotein transporter that handles it. St. John's wort and activated charcoal can pull levels down, which risks the treatment falling short of a cure, while grapefruit can push them high enough to add side effects. Those three carry the major ratings.

Because treatment usually runs a matter of weeks, a dip in drug levels during that window costs more than it would with most medicines. The moderate entries mostly work those same pathways with weaker evidence, and a few bulky fiber products can blunt absorption unless swallowed well apart from a dose. Of the 144 ingredients on file, 103 rate moderate and 38 minor, but sorting out the three majors before your first dose matters most.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 103 Minor 38 No known interaction 1,308

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Glecaprevir, Pibrentasvir: Top Interactions at a Glance

The most significant Glecaprevir, Pibrentasvir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 144 interacting ingredients — plus 1,308 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Glecaprevir, Pibrentasvir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Glecaprevir, Pibrentasviri

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Glecaprevir, Pibrentasviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Glecaprevir, Pibrentasviri

St.

Read the full interaction
The complete list

Every Supplement Checked Against Glecaprevir, Pibrentasvir

All 1,452 ingredients in our database, ranked by severity — 144 with a Glecaprevir, Pibrentasvir interaction on file and 1,308 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glecaprevir, Pibrentasvir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take St. John's Wort with Glecaprevir, Pibrentasvir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Glecaprevir, Pibrentasvir answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Delta-9-tetrahydrocannabinol (thc) + Glecaprevir, Pibrentasvir answer

Can you take Kava with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Glecaprevir, Pibrentasvir answer

Can you take Kratom with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Glecaprevir, Pibrentasvir answer

Can you take Lemongrass with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Glecaprevir, Pibrentasvir answer

Can you take Lentinan with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Glecaprevir, Pibrentasvir answer

Can you take Licorice with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Glecaprevir, Pibrentasvir answer

Can you take Lime with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Glecaprevir, Pibrentasvir answer

Can you take Methoxylated Flavones with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Glecaprevir, Pibrentasvir answer

Can you take Moringa with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Glecaprevir, Pibrentasvir answer

Can you take Neem with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Glecaprevir, Pibrentasvir answer

Can you take Oregon Grape with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Glecaprevir, Pibrentasvir answer

Can you take Padang Cassia with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Glecaprevir, Pibrentasvir answer

Can you take Panax Ginseng with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.

Full Panax Ginseng + Glecaprevir, Pibrentasvir answer

Can you take Peony with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Glecaprevir, Pibrentasvir answer

Can you take Peppermint with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Glecaprevir, Pibrentasvir answer

Can you take Phellodendron with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.

Full Phellodendron + Glecaprevir, Pibrentasvir answer

Can you take Propolis with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Glecaprevir, Pibrentasvir answer

Can you take Quercetin with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Glecaprevir, Pibrentasvir answer

Can you take Rabdosia Rubescens with Glecaprevir, Pibrentasvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Glecaprevir, Pibrentasvir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glecaprevir, Pibrentasvir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glecaprevir, Pibrentasvir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glecaprevir, Pibrentasvir sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Glecaprevir, Pibrentasvir through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Glecaprevir, Pibrentasvir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glecaprevir, Pibrentasvir through this category.

About Glecaprevir, Pibrentasvir

Glecaprevir and pibrentasvir is a combination antiviral used to treat hepatitis C virus (HCV) infection across all major genotypes in adults and children aged 3 and older.

Generic name: Glecaprevir, Pibrentasvir  ·  Brand name: Mavyret.

See the full Glecaprevir and Pibrentasvir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glecaprevir, Pibrentasvir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glecaprevir, Pibrentasvir.

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Pharmacist Counseling Corner

Glecaprevir, Pibrentasvir & Supplements: Common Questions

What supplements interact with Glecaprevir, Pibrentasvir?
In our interaction database, 144 supplement and herbal ingredients have an interaction with Glecaprevir, Pibrentasvir on file — 3 rated major, 103 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Glecaprevir, Pibrentasvir supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Glecaprevir, Pibrentasvir?
That depends entirely on which supplement. The honest answer for Glecaprevir, Pibrentasvir is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Mavyret have the same supplement interactions as Glecaprevir, Pibrentasvir?
Yes — Mavyret all contain Glecaprevir, Pibrentasvir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Glecaprevir, Pibrentasvir and my other medications?
This page covers Glecaprevir, Pibrentasvir against supplements and herbal ingredients. Checking Glecaprevir, Pibrentasvir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Glecaprevir and Pibrentasvir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.