Drug & supplement interaction

Senega + Glecaprevir, Pibrentasvir

Glecaprevir, Pibrentasvir brand name: Mavyret.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Senega and Glecaprevir, Pibrentasvir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glecaprevir, Pibrentasvir states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Senega and Glecaprevir, Pibrentasvir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glecaprevir, Pibrentasvir and Senega in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Senega at all — not against Glecaprevir, Pibrentasvir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Senega safety at a glance

Senega overall Use caution May be used short-term in traditional doses, but it can irritate the stomach and human evidence is limited.
Pregnancy Likely Unsafe When used orally; senega appears to have uterine and menstrual flow stimulant effects. There is insufficient reliable information available about the safety of... Read the full pregnancy detail
Breastfeeding Avoid There is too little safety information, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glecaprevir, Pibrentasvir and Senega? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Senega and Glecaprevir, Pibrentasvir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea / Diarrhea / Vomiting reported in 10.4% of FDA reports for Glecaprevir, Pibrentasvir Additional detail

    Senega

    “Orally, senega seems to be well tolerated. The most common adverse effects are gastrointestinal irritation, dyspepsia, diarrhea, queasiness, vomiting, and dizziness. These adverse effects are usually associated with large doses or prolonged use (2,4,8,18,96992).”

    Senega · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    3. 8. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
    4. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    5. 96992. Shin KY, Lee JY, Won BY, et al. BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 2009;465(2):157-9. PubMed

    “Orally, senega can cause mild dyspepsia. Prolonged use of senega can cause gastrointestinal irritation (2). Large doses of senega can cause diarrhea (8), queasiness (18), and vomiting (4).”

    Senega · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 96992. Shin KY, Lee JY, Won BY, et al. BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 2009;465(2):157-9. PubMed
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    3. 8. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
    4. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    5. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Glecaprevir, Pibrentasvir

    Listed in the ADVERSE REACTIONS section of the FDA label for Glecaprevir, Pibrentasvir, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Senega but not commonly for Glecaprevir, Pibrentasvir: stomach upset, dizziness, a stuffy or runny nose and wheezing.

Effects for Glecaprevir, Pibrentasvir come from the ADVERSE REACTIONS section of its FDA label; effects for Senega come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 10,923 voluntary FDA FAERS reports for Glecaprevir, Pibrentasvir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Senega in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; senega appears to have uterine and menstrual flow stimulant effects. There is insufficient reliable information available about the safety of the topical use of senega during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Glecaprevir, Pibrentasvir Products Have a Food Rule — Senega Should Not Break It

At least one FDA label for a product containing Glecaprevir, Pibrentasvir says to take it with food. If you take Senega on an empty stomach out of habit, keep them separate — and take Glecaprevir, Pibrentasvir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glecaprevir, Pibrentasvir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended dosage in adults: Three tablets taken at the same time orally once daily (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) with food.

From the Dosage and Administration section of the FDA label we read for Glecaprevir, Pibrentasvir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Glecaprevir, Pibrentasvir

This page covers Senega only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glecaprevir, Pibrentasvir page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Glecaprevir, Pibrentasvir page

“Mavyret (glecaprevir and pibrentasvir) is a short course of pills meant to cure hepatitis C, so I read its supplement list with real caution. Nearly everything on it can shift how much of the drug reaches your blood, mostly through the CYP3A4 enzyme or the P-glycoprotein transporter that handles it.”

Reviewed by 2 · Jul 18, 2026

Open the Glecaprevir, Pibrentasvir interaction page

How much people look this up

Where Senega and Glecaprevir, Pibrentasvir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Senega
Steady interest

#1,366 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glecaprevir, Pibrentasvir
Top 10%

#166 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Senega reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Senega and Glecaprevir, Pibrentasvir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Senega

What is Senega?

  • Cough and chest congestion
  • Bronchitis
  • Phlegm (as an expectorant)
  • Sore throat
  • Asthma symptoms (traditional)

Senega is a traditional herbal remedy made from the root of the Polygala senega plant, used mainly as an expectorant to help loosen mucus and ease coughs. Solid human evidence for its effects is limited, and it can upset the stomach, so talk with a pharmacist or doctor before using it—especially if you are pregnant, breastfeeding, or have a chronic health condition.

Polygala senega · Polygalaceae · Dried root and rhizome · Dried root, tea, tincture, liquid extract, syrup, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Senega is a good idea for someone in your situation. Here is what our Senega record says about it on its own.

Senega: dosing

There is no well-established standardized dose for senega, and the amount can vary widely between products such as teas, tinctures, and syrups. Because of this, the safest approach is to follow the directions on the specific product label.Do not exceed the recommended amount, since higher doses mainly increase the risk of stomach upset rather than benefit.

From our Senega monograph — the full record covers uses, side effects and every documented interaction.

Read the full Senega monograph & all interactions
Medication

About Glecaprevir and Pibrentasvir

What Is Glecaprevir and Pibrentasvir Used For?

Brand name: Mavyret

Mavyret treats acute or chronic hepatitis C virus (HCV) infection caused by genotypes 1, 2, 3, 4, 5, or 6 in adults and children 3 years and older who have no cirrhosis or have compensated cirrhosis (mild liver scarring that is still functioning).

Mavyret is also approved for adults and children 3 years and older with genotype 1 HCV who were previously treated with either an NS5A inhibitor or an NS3/4A protease inhibitor (two earlier classes of hepatitis C drugs) — but not both at the same time.

See full Glecaprevir and Pibrentasvir drug information
Keep checking

Other Drugs & Senega

Browse every other medication we’ve checked against Senega — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Senega against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Senega list.

See the full Senega interactions page
See every supplement checked against Glecaprevir, Pibrentasvir, ranked by severity
Evidence & sources

Senega References

The 9 references that drive our Senega monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Park HK, Jeon SG, Kim TB, et al. Occupational asthma and rhinitis induced by a herbal medicine, Wonji (Polygala tenuifolia). J Korean Med Sci. 2005;20(1):46-9. PubMed
  8. Lee JY, Kim KY, Shin KY, Won BY, Jung HY, Suh YH. Effects of BT-11 on memory in healthy humans. Neurosci Lett. 2009;454(2):111-4. PubMed
  9. Shin KY, Lee JY, Won BY, et al. BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 2009;465(2):157-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Senega and Glecaprevir, Pibrentasvir Together: Common Questions

Is it safe to take Senega with Glecaprevir, Pibrentasvir?
We do not list a known interaction between Senega and Glecaprevir, Pibrentasvir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Senega and Glecaprevir, Pibrentasvir have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Senega and Glecaprevir, Pibrentasvir at the same time of day?
At least one FDA label for a product containing Glecaprevir, Pibrentasvir says to take it with food. If you take Senega on an empty stomach out of habit, keep them separate and take Glecaprevir, Pibrentasvir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glecaprevir, Pibrentasvir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Glecaprevir, Pibrentasvir interact with any supplements?
Yes. Glecaprevir, Pibrentasvir has documented interactions with 144 supplements in our database — Senega is not one of them. The Glecaprevir, Pibrentasvir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Senega monograph Uses, safety profile, and every drug interaction in one place Glecaprevir and Pibrentasvir drug information The full plain-English guide to this medication Glecaprevir, Pibrentasvir supplement interactions Every supplement checked against Glecaprevir, Pibrentasvir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glecaprevir, Pibrentasvir and Senega?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.