Drug & supplement interaction

Proteolytic Enzymes (proteases) + Amoxapine

Amoxapine brand name: Asendin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Proteolytic Enzymes (proteases) and Amoxapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Proteolytic Enzymes (proteases) and Amoxapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amoxapine and Proteolytic Enzymes (proteases) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Proteolytic Enzymes (proteases) at all — not against Amoxapine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Proteolytic Enzymes (proteases) safety at a glance

Proteolytic Enzyme... overall Use caution Generally well tolerated for most adults, but may cause digestive upset or allergic reactions.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy unless prescribed.
Breastfeeding Use caution There is little safety data during breastfeeding, so use is not recommended without medical advice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amoxapine and Proteolytic Enzymes (proteases)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Proteolytic Enzymes (proteases) Itself Has Been Linked To

This is not an interaction — nothing below involves Amoxapine. It is the side-effect record for Proteolytic Enzymes (proteases) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Proteolytic Enzymes (proteases), this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Proteolytic enzymes are commonly found in laundry detergents and pre-spotter products. Rarely, protease specific IgE positive tests possibly related to these products have occurred. Exposure may be airborne or topical. In addition, in case reports, occupational exposure to the airborne proteolytic enzyme pepsin has resulted in allergic rhinoconjunctivitis or asthma.”

    Proteolytic Enzymes (proteases) · Natural Medicines adverse-effect record, reported in asthma.

    3 sources cited
    1. 102705. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
    2. 102706. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
    3. 102707. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Proteolytic Enzymes (proteases) — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Amoxapine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Amoxapine column appears here.

Everything else you take

See Every Supplement That Interacts With Amoxapine

This page covers Proteolytic Enzymes (proteases) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amoxapine page lists 68 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), Scopolia (major), 5-htp (moderate) and Acetyl-l-carnitine (moderate).

By severity: 3 major · 49 moderate · 16 minor.

From our pharmacist’s overview on the Amoxapine page

“Amoxapine (Asendin) is an older tricyclic antidepressant, and its supplement list deserves real care. Three of the 68 ingredients on file are rated major: activated charcoal can soak up the drug before your body gets it, lithium raises the risk of serotonin syndrome (a dangerous serotonin overload), and scopolia piles onto amoxapine's…”

Reviewed by 2 · Jul 18, 2026

Open the Amoxapine interaction page

One more smart check

Taking Proteolytic Enzymes (proteases) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 713 real supplement products containing Proteolytic Enzymes (proteases), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Proteolytic Enzymes (proteases). Even though Proteolytic Enzymes (proteases) itself has no known interaction with Amoxapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Proteolytic Enzymes (proteases) and Amoxapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Proteolytic Enzymes (proteases)
Top 5%

#39 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amoxapine
Top half

#982 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Proteolytic Enzymes (proteases) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Proteolytic Enzymes (proteases) and Amoxapine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Proteolytic Enzymes (proteases)

What is Proteolytic Enzymes (proteases)?

  • Digestion and bloating
  • Muscle soreness and exercise recovery
  • Inflammation and swelling
  • Sinus and respiratory congestion
  • Post-surgery or injury recovery

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. People take them for digestion, inflammation, and muscle recovery, but the evidence is mixed and stronger for some uses (like aiding digestion in people who lack natural enzymes) than others. They are generally well tolerated, but talk with a pharmacist or doctor before use, especially if you have allergies, a bleeding risk, or are pregnant.

Enzymes sourced from fruit (pineapple, papaya), animal pancreas, or microbial/fungal fermentation · Capsules, tablets (often enteric-coated), powders

An interaction check asks whether these two react with each other — it does not ask whether Proteolytic Enzymes (proteases) is a good idea for someone in your situation. Here is what our Proteolytic Enzymes (proteases) record says about it on its own.

Proteolytic Enzymes (proteases): dosing

There is no single standardized dose for proteolytic enzyme supplements. Products vary widely in their source, strength, and how they measure enzyme activity (for example, units may be listed differently from one brand to another).Because of this, the best approach is to follow the directions on the product label and not exceed the recommended amount. Do not assume an over-the-counter product replaces a prescription pancreatic enzyme.

From our Proteolytic Enzymes (proteases) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Proteolytic Enzymes (proteases) monograph & all interactions
Medication

About Amoxapine

What Is Amoxapine Used For?

Brand name: Asendin

Amoxapine is used to treat symptoms of depression. This includes neurotic or reactive depression (depression triggered by life events), as well as endogenous depression (depression that arises from within, without a clear external cause) and psychotic depression.

It is also indicated for depression that comes with significant anxiety or agitation.

See full Amoxapine drug information
Keep checking

Other Drugs & Proteolytic Enzymes (proteases)

Browse every other medication we’ve checked against Proteolytic Enzymes (proteases) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Proteolytic Enzymes (proteases) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Proteolytic Enzymes (proteases) list.

See the full Proteolytic Enzymes (proteases) interactions page
See every supplement checked against Amoxapine, ranked by severity
Evidence & sources

Proteolytic Enzymes (proteases) References

The 3 references that drive our Proteolytic Enzymes (proteases) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Proteolytic Enzymes (proteases) and Amoxapine Together: Common Questions

Is it safe to take Proteolytic Enzymes (proteases) with Amoxapine?
We do not list a known interaction between Proteolytic Enzymes (proteases) and Amoxapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Amoxapine interact with any supplements?
Yes. Amoxapine has documented interactions with 68 supplements in our database — Proteolytic Enzymes (proteases) is not one of them. The Amoxapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Proteolytic Enzymes (proteases) monograph Uses, safety profile, and every drug interaction in one place Amoxapine drug information The full plain-English guide to this medication Amoxapine supplement interactions Every supplement checked against Amoxapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amoxapine and Proteolytic Enzymes (proteases)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.