Drug & supplement interaction

Radish + Leuprolide Acetate, Norethindrone Acetate

Leuprolide Acetate, Norethindrone Acetate brand name: Lupaneta Pack.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Radish and Leuprolide Acetate, Norethindrone Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Radish and Leuprolide Acetate, Norethindrone Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leuprolide Acetate, Norethindrone Acetate and Radish in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Radish safety at a glance

Radish overall Generally safe Radish is widely eaten as food and is generally safe in normal dietary amounts.

Pregnancy Use caution Normal food amounts are likely fine, but concentrated supplements and unwashed raw sprouts should be avoided.

Breastfeeding Use caution Food amounts are likely fine, but safety of concentrated radish supplements is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leuprolide Acetate, Norethindrone Acetate and Radish? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Leuprolide Acetate, Norethindrone Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Leuprolide Acetate, Norethindrone Acetate is filed under 6 classifications — including progestin, cytochrome p450 2c19 (cyp2c19) inducers, cytochrome p450 1a2 (cyp1a2) inhibitors. Radish has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Leuprolide Acetate, Norethindrone Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Radish Does Interact With Other Medications

Radish has 86 moderate known drug interactions in our database — Leuprolide Acetate, Norethindrone Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Leuprolide Acetate, Norethindrone Acetate)

Taking anything else?

Check Another of Your Medications Against Radish

Covers the 2,830 medications we’ve checked against Radish. Pick one to open its full report.

What to actually watch for

What Radish Itself Has Been Linked To

This is not an interaction — nothing below involves Leuprolide Acetate, Norethindrone Acetate. It is the side-effect record for Radish on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Radish, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

Hives Worth acting on Additional detail
“A case of allergy to oral intake of radish has been reported. Symptoms included throat tightness and generalized urticaria.”

Radish · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).
1 source cited

94289. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
Stomach upset Additional detail
“Large amounts of radish may cause irritation of the gastrointestinal mucus membrane (18). Mild indigestion has also been associated with use of a specific product containing radish, camu camu, acerola, honey, and tapioca in clinical research. However, it is unclear if this adverse event is due to radish, other ingredients in the product, or the combination.”

Radish · Natural Medicines adverse-effect record, reported in dyspepsia.
2 sources cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

94290. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Radish — expand a row for the licensed statement it rests on. We haven’t matched Leuprolide Acetate, Norethindrone Acetate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Leuprolide Acetate, Norethindrone Acetate.

Everything else you take

See Every Supplement That Interacts With Leuprolide Acetate, Norethindrone Acetate

This page covers Radish only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leuprolide Acetate, Norethindrone Acetate page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 108 moderate · 41 minor.

From our pharmacist’s overview on the Leuprolide Acetate, Norethindrone Acetate page

“Lupaneta Pack (leuprolide acetate with norethindrone acetate) treats endometriosis pain, and the norethindrone tablet is where nearly all of these interactions land. Most ingredients on this page change how the liver handles that hormone through the CYP3A4 enzyme, some raising its level and side effects, others lowering it enough to we…”

Reviewed by 2 · Jul 18, 2026

Open the Leuprolide Acetate, Norethindrone Acetate interaction page

One more smart check

Taking Radish as Part of a Dietary Supplement Product? Check It for Interactions

We hold 644 real supplement products containing Radish, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Radish. Even though Radish itself has no known interaction with Leuprolide Acetate, Norethindrone Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Radish and Leuprolide Acetate, Norethindrone Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Radish

Top 25%

#294 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Leuprolide Acetate, Norethindrone Acetate

Steady interest

#2,151 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Radish reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Radish and Leuprolide Acetate, Norethindrone Acetate records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Radish

What is Radish?

Digestive support
Liver and gallbladder health
Antioxidant support
Respiratory and cough relief
General nutrition

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver support, but high-quality human evidence for supplement-level health benefits is limited. Eating radish as part of a normal diet is fine for most people; talk to your pharmacist or doctor before using concentrated supplements.

Raphanus sativus · Brassicaceae · Root, leaves, seeds, and sprouts · Fresh vegetable, juice, sprouts, powders, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Radish is a good idea for someone in your situation. Here is what our Radish record says about it on its own.

Radish: dosing

There is no standardized medicinal dose for radish. As a food, you can simply eat it as part of a normal diet.For radish juice, powders, or capsules, a proven supplement dose has not been established by research.

From our Radish monograph — the full record covers uses, side effects and every documented interaction.

Read the full Radish monograph & all interactions

Keep checking

Other Drugs & Radish

Browse every other medication we’ve checked against Radish — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

86Moderate

0Minor

2,743No known interaction

86 Moderate 2,743 No interaction

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Radish page.

No interaction 2,743 drugs checked — show the list

We also checked Radish against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Radish list.

See the full Radish interactions page

See every supplement checked against Leuprolide Acetate, Norethindrone Acetate, ranked by severity

Evidence & sources

Radish References

The 5 references that drive our Radish monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Radish and Leuprolide Acetate, Norethindrone Acetate Together: Common Questions

Is it safe to take Radish with Leuprolide Acetate, Norethindrone Acetate?

We do not list a known interaction between Radish and Leuprolide Acetate, Norethindrone Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Radish and Leuprolide Acetate, Norethindrone Acetate combination checked?

Interactions in our licensed database are recorded against drug classes. Leuprolide Acetate, Norethindrone Acetate is filed under 6 classifications, and Radish has documented interactions with 1 drug class — none of Leuprolide Acetate, Norethindrone Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Radish interact with any other medications?

Yes. Radish has 86 documented drug interactions in our database — Leuprolide Acetate, Norethindrone Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Leuprolide Acetate, Norethindrone Acetate interact with any supplements?

Yes. Leuprolide Acetate, Norethindrone Acetate has documented interactions with 152 supplements in our database — Radish is not one of them. The Leuprolide Acetate, Norethindrone Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Radish monograph Uses, safety profile, and every drug interaction in one place Leuprolide Acetate, Norethindrone Acetate supplement interactions Every supplement checked against Leuprolide Acetate, Norethindrone Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leuprolide Acetate, Norethindrone Acetate and Radish?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.