Medication interaction hub

What Supplements Interact with Leuprolide Acetate, Norethindrone Acetate?

Leuprolide Acetate, Norethindrone Acetate brand name: Lupaneta Pack. Every interaction below applies to the brands too.

152 Interactions 3 Major 108 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Leuprolide Acetate, Norethindrone Acetate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Leuprolide Acetate, Norethindrone Acetate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lupaneta Pack (leuprolide acetate with norethindrone acetate) treats endometriosis pain, and the norethindrone tablet is where nearly all of these interactions land. Most ingredients on this page change how the liver handles that hormone through the CYP3A4 enzyme, some raising its level and side effects, others lowering it enough to weaken the protection it is meant to give. I would give this list genuine, careful attention, starting with the three rated major: grapefruit, St. John's wort, and activated charcoal, which either swing hormone levels sharply or keep the pill from being absorbed at all.

A smaller group works in the gut instead of the liver, binding or slowing the tablet so less of it gets in; those need spacing well apart from the dose. Since the norethindrone exists partly to protect bone during leuprolide treatment, anything that drains it matters. The other 149 entries split into 108 moderate and 41 minor.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 108 Minor 41 No known interaction 1,300

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Leuprolide Acetate, Norethindrone Acetate: Top Interactions at a Glance

The Leuprolide Acetate, Norethindrone Acetate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 152 interacting ingredients — plus 1,300 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Leuprolide Acetate, Norethindrone Acetate Combinations Today

The Leuprolide Acetate, Norethindrone Acetate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Tea + Leuprolide Acetate, Norethindrone Acetatei

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Leuprolide Acetate, Norethindrone Acetatei

Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Read the full interaction Moderate Likelihood Possible Lentinan + Leuprolide Acetate, Norethindrone Acetatei

Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Possible Sulforaphane + Leuprolide Acetate, Norethindrone Acetatei

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Leuprolide Acetate, Norethindrone Acetatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Leuprolide Acetate, Norethindrone Acetatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Leuprolide Acetate, Norethindrone Acetate

All 1,452 ingredients in our database, ranked by severity — 152 with a Leuprolide Acetate, Norethindrone Acetate interaction on file and 1,300 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Leuprolide Acetate, Norethindrone Acetate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Black Tea + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Red Yeast Rice with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Full Red Yeast Rice + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Lentinan with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Sulforaphane with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.

Full Sulforaphane + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Syrian Rue with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Terminalia with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Thunder God Vine with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of thunder god vine constituents.

Full Thunder God Vine + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Tragacanth with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Turmeric with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Uva Ursi with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Vitamin E with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Leuprolide Acetate, Norethindrone Acetate answer

Can you take White Pepper with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Wild Cherry with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Yohimbe with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.

Full Yohimbe + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Zedoary with Leuprolide Acetate, Norethindrone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Thyroid Extract with Leuprolide Acetate, Norethindrone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Aegeline with Leuprolide Acetate, Norethindrone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Agar with Leuprolide Acetate, Norethindrone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Algin with Leuprolide Acetate, Norethindrone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Leuprolide Acetate, Norethindrone Acetate answer

Can you take Ashwagandha with Leuprolide Acetate, Norethindrone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Leuprolide Acetate, Norethindrone Acetate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Leuprolide Acetate, Norethindrone Acetate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Leuprolide Acetate, Norethindrone Acetate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Leuprolide Acetate, Norethindrone Acetate sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Leuprolide Acetate, Norethindrone Acetate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Leuprolide Acetate, Norethindrone Acetate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Leuprolide Acetate, Norethindrone Acetate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Leuprolide Acetate, Norethindrone Acetate through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Leuprolide Acetate, Norethindrone Acetate through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Leuprolide Acetate, Norethindrone Acetate through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Leuprolide Acetate, Norethindrone Acetate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Leuprolide Acetate, Norethindrone Acetate.

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Pharmacist Counseling Corner

Leuprolide Acetate, Norethindrone Acetate & Supplements: Common Questions

What supplements interact with Leuprolide Acetate, Norethindrone Acetate?
In our interaction database, 152 supplement and herbal ingredients have an interaction with Leuprolide Acetate, Norethindrone Acetate on file — 3 rated major, 108 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Leuprolide Acetate, Norethindrone Acetate supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Leuprolide Acetate, Norethindrone Acetate?
That depends entirely on which supplement. The honest answer for Leuprolide Acetate, Norethindrone Acetate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Lupaneta Pack have the same supplement interactions as Leuprolide Acetate, Norethindrone Acetate?
Yes — Lupaneta Pack all contain Leuprolide Acetate, Norethindrone Acetate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Leuprolide Acetate, Norethindrone Acetate and my other medications?
This page covers Leuprolide Acetate, Norethindrone Acetate against supplements and herbal ingredients. Checking Leuprolide Acetate, Norethindrone Acetate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.