Drug & supplement interaction

Red-spur Valerian + Naltrexone

Naltrexone brand names: Trexan, Depade, Vivitrol.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Red-spur Valerian and Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Red-spur Valerian and Naltrexone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naltrexone and Red-spur Valerian in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Red-spur Valerian at all — not against Naltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red-spur Valerian safety at a glance

Red-spur Valerian overall Not established There is very little reliable safety data on red-spur valerian in humans.
Pregnancy Avoid Safety is unknown, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is no safety information for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naltrexone and Red-spur Valerian? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Naltrexone’s Own FDA Label Lists

This is not an interaction — none of it involves Red-spur Valerian. These are the most notable effects listed in the ADVERSE REACTIONS section of Naltrexone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • A stroke or mini-stroke Worth acting on
  • A bowel blockage Worth acting on
  • Dehydration Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on

Showing the 10 most notable of 62 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naltrexone. Read the label on DailyMed › Where a percentage is shown, it is the share of 40,504 voluntary FDA FAERS reports for Naltrexone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Red-spur Valerian’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Red-spur Valerian side to compare — that is a limit of the record, not a statement that Red-spur Valerian has no side effects.

Everything else you take

See Every Supplement That Interacts With Naltrexone

This page covers Red-spur Valerian only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naltrexone page lists 56 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 43 moderate · 9 minor.

From our pharmacist’s overview on the Naltrexone page

“The single biggest risk on this page is to your liver. Naltrexone (Vivitrol, Depade), prescribed for alcohol and opioid dependence, carries its own warnings about liver stress at higher doses, and 38 of the 56 supplements here share that liability, led by Siberian cocklebur, a major-rated entry tied to outright liver failure.”

Reviewed by 2 · Jul 18, 2026

Open the Naltrexone interaction page

How much people look this up

Where Red-spur Valerian and Naltrexone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red-spur Valerian
Steady interest

#756 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naltrexone
Top 5%

#99 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Red-spur Valerian is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red-spur Valerian reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red-spur Valerian and Naltrexone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red-spur Valerian

What is Red-spur Valerian?

Red-spur Valerian
  • Sleep and relaxation
  • Anxiety and nervousness
  • Digestive upset
  • Headaches

Red-spur valerian (Centranthus ruber) is a Mediterranean ornamental plant that has been used in folk medicine as a mild sedative, but there is almost no modern scientific research to support these uses. It is a different plant from true valerian (Valeriana officinalis), and its safety has not been well studied, so caution is warranted—especially during pregnancy, breastfeeding, and in children.

Centranthus ruber · Caprifoliaceae · Roots, leaves, and flowering tops · Rarely sold as a commercial supplement; traditionally used as teas or dried plant preparations

An interaction check asks whether these two react with each other — it does not ask whether Red-spur Valerian is a good idea for someone in your situation. Here is what our Red-spur Valerian record says about it on its own.

Red-spur Valerian: dosing

There is no established or standardized dose for red-spur valerian. It is not a common commercial supplement, and reliable dosing guidelines have not been set through research.If you find a product that contains it, follow the directions on the label and do not exceed the recommended amount.

From our Red-spur Valerian monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red-spur Valerian monograph & all interactions
Medication

About Naltrexone

What Is Naltrexone Used For?

Brand names: Trexan, Depade, Vivitrol

Naltrexone Hydrochloride tablets are used to treat alcohol dependence and to block the effects of opioids in people with opioid dependence. The extended-release injectable suspension — sold as Vivitrol and also available as a generic injectable — is used to treat alcohol dependence and to prevent relapse to opioid dependence after a person has completed opioid detoxification.

All formulations are meant to be part of a broader treatment plan that includes counseling and other support — naltrexone works best when it is not used alone.

Most-Reported Side Effects for Naltrexone

From FAERS, the FDA’s public side-effect reporting system (40,504 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site reaction 4,417 reports
Nausea 4,208 reports
Injection site pain 3,192 reports
Headache 2,685 reports
Fatigue 2,479 reports
See full Naltrexone drug information
Keep checking

Other Drugs & Red-spur Valerian

Browse every other medication we’ve checked against Red-spur Valerian — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Red-spur Valerian against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Red-spur Valerian list.

See the full Red-spur Valerian interactions page
See every supplement checked against Naltrexone, ranked by severity
Evidence & sources

Red-spur Valerian References

The 2 sources that drive our Red-spur Valerian monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Red-spur Valerian is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Valerian - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Valerian — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red-spur Valerian and Naltrexone Together: Common Questions

Is it safe to take Red-spur Valerian with Naltrexone?
We do not list a known interaction between Red-spur Valerian and Naltrexone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Naltrexone interact with any supplements?
Yes. Naltrexone has documented interactions with 56 supplements in our database — Red-spur Valerian is not one of them. The Naltrexone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red-spur Valerian monograph Uses, safety profile, and every drug interaction in one place Naltrexone drug information The full plain-English guide to this medication Naltrexone supplement interactions Every supplement checked against Naltrexone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naltrexone and Red-spur Valerian?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.