Drug & supplement interaction

Rice Bran + Treprostinil (IV)

Treprostinil (IV) brand name: Remodulin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rice Bran and Treprostinil (IV) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rice Bran and Treprostinil (IV)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Treprostinil (IV) and Rice Bran in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Rice Bran at all — not against Treprostinil (IV), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rice Bran safety at a glance

Rice Bran overall Use caution Generally safe as food, but concentrated supplements have less safety data and may cause digestive effects.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for medicinal... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for medicinal... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Treprostinil (IV) and Rice Bran? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Rice Bran and Treprostinil (IV) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Rice Bran

    “Orally and topically, rice bran can cause allergic reactions such as urticaria, angioedema, wheezing, itching, and cough. In a case report, a 5-year-old male presented with allergic eczema, urticaria, and cough due to rice bran ingestion. In another case report, a 14-year-old male developed food-dependent, exercise-induced anaphylaxis after consuming 150 grams of rice bran.”

    Rice Bran · Natural Medicines adverse-effect record, reported in cough.

    3 sources cited
    1. 100733. Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
    2. 106589. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed
    3. 100732. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed

    Treprostinil (IV)

    Listed in the ADVERSE REACTIONS section of the FDA label for Treprostinil (IV). Read the label on DailyMed ›

  • A skin rash Additional detail

    Rice Bran

    “Topically, rice bran broth baths can cause itching and skin redness. In rare cases, rash and itching from rice bran has been associated with contact infestation with Pyemotes tritici, an arthropod commonly called straw itch mite.”

    Rice Bran · Natural Medicines adverse-effect record, reported in pruritus.

    2 sources cited
    1. 872. Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
    2. 2284. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI

    Treprostinil (IV)

    Listed in the ADVERSE REACTIONS section of the FDA label for Treprostinil (IV). Read the label on DailyMed ›

Reported for Rice Bran but not commonly for Treprostinil (IV): stomach upset, an allergic reaction, a severe allergic reaction and bloating or gas.

Effects for Treprostinil (IV) come from the ADVERSE REACTIONS section of its FDA label; effects for Rice Bran come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rice Bran in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for medicinal purposes during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Treprostinil (IV) Is Prescribed For, and What Rice Bran Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Treprostinil (IV) is a prescription medicine with approved uses on its FDA label. Rice Bran is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Treprostinil (IV) is prescribed for: Treprostinil injection is used to treat pulmonary arterial hypertension (PAH, WHO Group 1) — high blood pressure in the arteries that supply the lungs. It works to reduce the symptoms that make exercise difficult. Clinical studies included patients with moderate-to-severe PAH symptoms (NYHA Class II–IV) due to idiopathic or heritable PAH, PAH related to congenital heart defects, and PAH related to connective tissue diseases. It is also used for PAH patients who need to transition off epoprostenol — a related medication — to slow the worsening of their condition during that switch.

Read the rest of what Treprostinil (IV) is prescribed for

The risks and benefits of the transition should be carefully discussed with a specialist before starting.

Rice Bran has been studied for:

  • Hypertension studied, not established Rice Bran has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Rice Bran for hypertension

    Although there has been interest in using oral rice bran for hypertension, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Treprostinil (IV) on your own; if you are taking Rice Bran for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Treprostinil (IV)

This page covers Rice Bran only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Treprostinil (IV) page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Mistletoe (major), Danshen (major), Piracetam (major), Aconite (moderate) and African Wild Potato (moderate).

By severity: 3 major · 191 moderate · 18 minor.

From our pharmacist’s overview on the Treprostinil (IV) page

“Bleeding risk is the thread running through nearly every supplement flagged for treprostinil (Remodulin), the IV therapy for pulmonary arterial hypertension. The drug itself discourages platelets from clumping, so the overwhelming majority of these ingredients could push that tendency further, and I would not add anything from this pag…”

Reviewed by 2 · Jul 18, 2026

Open the Treprostinil (IV) interaction page

One more smart check

Taking Rice Bran as Part of a Dietary Supplement Product? Check It for Interactions

We hold 708 real supplement products containing Rice Bran, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rice Bran. Even though Rice Bran itself has no known interaction with Treprostinil (IV), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rice Bran and Treprostinil (IV) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rice Bran
Top 25%

#318 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Treprostinil (IV)
Top 25%

#543 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rice Bran reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rice Bran and Treprostinil (IV) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rice Bran

What is Rice Bran?

  • High cholesterol
  • Digestive health and fiber
  • Heart health support
  • Blood sugar support
  • Skin care (topical oil)

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most other uses the evidence is limited. It is generally considered safe as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Oryza sativa · Poaceae · Bran (the outer layer of the rice grain) and rice bran oil · Powder, capsules, tablets, rice bran oil, and as a fiber food additive

An interaction check asks whether these two react with each other — it does not ask whether Rice Bran is a good idea for someone in your situation. Here is what our Rice Bran record says about it on its own.

Rice Bran: dosing

There is no single official or standardized dose for rice bran supplements. The right amount depends on the product, the form (powder, capsule, or oil), and your reason for using it.The best approach is to follow the directions on the product label and not exceed the recommended amount. If you are adding rice bran for fiber, start with a small amount and increase slowly while drinking plenty of water.

From our Rice Bran monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rice Bran monograph & all interactions
Medication

About Treprostinil Injection

What Is Treprostinil Injection Used For?

Brand name: Remodulin

Treprostinil injection is used to treat pulmonary arterial hypertension (PAH, WHO Group 1) — high blood pressure in the arteries that supply the lungs. It works to reduce the symptoms that make exercise difficult. Clinical studies included patients with moderate-to-severe PAH symptoms (NYHA Class II–IV) due to idiopathic or heritable PAH, PAH related to congenital heart defects, and PAH related to connective tissue diseases.

It is also used for PAH patients who need to transition off epoprostenol — a related medication — to slow the worsening of their condition during that switch. The risks and benefits of the transition should be carefully discussed with a specialist before starting.

See full Treprostinil Injection drug information
Keep checking

Other Drugs & Rice Bran

Browse every other medication we’ve checked against Rice Bran — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Rice Bran against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Rice Bran list.

See the full Rice Bran interactions page
See every supplement checked against Treprostinil (IV), ranked by severity
Evidence & sources

Rice Bran References

The 7 references that drive our Rice Bran monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
  3. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
  4. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
  5. Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
  6. So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
  7. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rice Bran and Treprostinil (IV) Together: Common Questions

Is it safe to take Rice Bran with Treprostinil (IV)?
We do not list a known interaction between Rice Bran and Treprostinil (IV). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rice Bran and Treprostinil (IV) have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Rice Bran and Treprostinil (IV) used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Rice Bran in each. That is a conversation for your prescriber, especially if Treprostinil (IV) is being adjusted to a target.
Does Treprostinil (IV) interact with any supplements?
Yes. Treprostinil (IV) has documented interactions with 212 supplements in our database — Rice Bran is not one of them. The Treprostinil (IV) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rice Bran monograph Uses, safety profile, and every drug interaction in one place Treprostinil Injection drug information The full plain-English guide to this medication Treprostinil (IV) supplement interactions Every supplement checked against Treprostinil (IV), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Treprostinil (IV) and Rice Bran?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.