Drug & supplement interaction

Royal Jelly + Gemcitabine

Gemcitabine brand name: Gemzar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Royal Jelly and Gemcitabine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Royal Jelly and Gemcitabine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Gemcitabine and Royal Jelly in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Royal Jelly safety at a glance

Royal Jelly overall Use caution Generally well tolerated, but it can trigger serious allergic reactions in sensitive people.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Gemcitabine and Royal Jelly? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Gemcitabine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Gemcitabine is filed under 2 classifications — antineoplastics, hepatotoxic drugs. Royal Jelly has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (moderate) and warfarin (coumadin) (moderate) — and none of Gemcitabine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Royal Jelly Does Interact With Other Medications

Royal Jelly has 174 moderate known drug interactions in our database — Gemcitabine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 174 No known interaction 2,656 (incl. Gemcitabine)
Taking anything else?

Check Another of Your Medications Against Royal Jelly

Covers the 2,830 medications we’ve checked against Royal Jelly. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Royal Jelly and Gemcitabine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Royal Jelly

    “In people with a history of atopy or asthma, royal jelly taken orally appears to cause a high rate of allergic symptoms including pruritus, urticaria, eczema, eyelid and facial edema, conjunctivitis, rhinorrhea, dyspnea, oral allergy syndrome, and asthma. In severe cases, royal jelly can cause status asthmaticus, anaphylaxis, and death.”

    Royal Jelly · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 792. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
    2. 7315. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
    3. 7316. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
    4. 10623. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
    5. 10624. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
    6. 108511. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

    Gemcitabine

    Listed in the ADVERSE REACTIONS section of the FDA label for Gemcitabine. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Gemcitabine

    Listed in the ADVERSE REACTIONS section of the FDA label for Gemcitabine. Read the label on DailyMed ›

  • Swelling Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Gemcitabine

    Listed in the ADVERSE REACTIONS section of the FDA label for Gemcitabine. Read the label on DailyMed ›

  • A skin rash Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Gemcitabine

    Listed in the ADVERSE REACTIONS section of the FDA label for Gemcitabine. Read the label on DailyMed ›

Reported for Royal Jelly but not commonly for Gemcitabine: stomach pain, a severe allergic reaction, dizziness and hives.

Effects for Gemcitabine come from the ADVERSE REACTIONS section of its FDA label; effects for Royal Jelly come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 53,020 voluntary FDA FAERS reports for Gemcitabine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Gemcitabine

This page covers Royal Jelly only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gemcitabine page lists 39 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).

By severity: 3 major · 35 moderate · 1 minor.

Open the Gemcitabine interaction page

One more smart check

Taking Royal Jelly as Part of a Dietary Supplement Product? Check It for Interactions

We hold 677 real supplement products containing Royal Jelly, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Royal Jelly. Even though Royal Jelly itself has no known interaction with Gemcitabine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Royal Jelly and Gemcitabine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Royal Jelly
Top 25%

#308 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gemcitabine
Steady interest

#2,203 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Royal Jelly reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Royal Jelly and Gemcitabine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Royal Jelly

What is Royal Jelly?

Royal Jelly
  • Menopausal symptoms
  • Skin health and wound care
  • Immune support
  • General energy and vitality
  • Cholesterol support
  • Eye dryness (eye drops)

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limited for most uses. It is generally well tolerated by most people, but it can cause serious allergic reactions, especially in those allergic to bees or with asthma.

Secretion from the glands of worker honey bees (Apis mellifera) · Capsules, softgels, fresh (frozen) jelly, liquid, powder, and skin creams

An interaction check asks whether these two react with each other — it does not ask whether Royal Jelly is a good idea for someone in your situation. Here is what our Royal Jelly record says about it on its own.

Royal Jelly: dosing

There is no official or standardized dose of royal jelly. The amounts used in studies have varied widely, and products differ in their strength and purity.Because there is no proven best dose, it is wise to follow the directions on the product label and not take more than recommended.

From our Royal Jelly monograph — the full record covers uses, side effects and every documented interaction.

Read the full Royal Jelly monograph & all interactions
Medication

About Gemcitabine Injection

What Is Gemcitabine Injection Used For?

Brand name: Gemzar

Gemcitabine Injection (available as Avgemsi, Gemcitabine, and Infugem) is used to treat several types of cancer. It is given in combination with carboplatin for advanced ovarian cancer that has returned at least 6 months after platinum-based treatment, and in combination with paclitaxel as a first-line treatment for metastatic breast cancer after prior chemotherapy with an anthracycline (a specific class of chemo drug).

It is also given in combination with cisplatin for non-small cell lung cancer (NSCLC) that cannot be removed surgically or has spread. For pancreatic cancer that is locally advanced or has spread, it is used as a single agent — including in patients who have already been treated with fluorouracil.

Most-Reported Side Effects for Gemcitabine

From FAERS, the FDA’s public side-effect reporting system (53,020 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 4,850 reports
Thrombocytopenia 3,706 reports
Neutropenia 3,295 reports
Anemia 3,084 reports
Malignant neoplasm progression 2,912 reports
See full Gemcitabine Injection drug information
Keep checking

Other Drugs & Royal Jelly

Browse every other medication we’ve checked against Royal Jelly — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
174Moderate
0Minor
2,655No known interaction
174 Moderate 2,655 No interaction
Moderate

174 interactions

Showing 60 of 174 moderate interactions — see all 174 on the Royal Jelly page.

No interaction 2,655 drugs checked — show the list

We also checked Royal Jelly against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,655 medications checked with no known interaction — see the full Royal Jelly list.

See the full Royal Jelly interactions page
See every supplement checked against Gemcitabine, ranked by severity
Evidence & sources

Royal Jelly References

The 14 references that drive our Royal Jelly monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
  2. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
  3. Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
  4. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
  5. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
  6. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
  7. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
  8. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
  9. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  10. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
  11. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  12. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
  13. Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
  14. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Royal Jelly and Gemcitabine Together: Common Questions

Is it safe to take Royal Jelly with Gemcitabine?
We do not list a known interaction between Royal Jelly and Gemcitabine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Royal Jelly and Gemcitabine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Royal Jelly and Gemcitabine combination checked?
Interactions in our licensed database are recorded against drug classes. Gemcitabine is filed under 2 classifications, and Royal Jelly has documented interactions with 2 drug classes — none of Gemcitabine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Royal Jelly interact with any other medications?
Yes. Royal Jelly has 174 documented drug interactions in our database — Gemcitabine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Gemcitabine interact with any supplements?
Yes. Gemcitabine has documented interactions with 39 supplements in our database — Royal Jelly is not one of them. The Gemcitabine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Royal Jelly monograph Uses, safety profile, and every drug interaction in one place Gemcitabine Injection drug information The full plain-English guide to this medication Gemcitabine supplement interactions Every supplement checked against Gemcitabine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Gemcitabine and Royal Jelly?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.