Drug & supplement interaction

Rye Grass + nitisinone

nitisinone brand names: Orfadin, Nityr.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rye Grass and nitisinone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Rye Grass and nitisinone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between nitisinone and Rye Grass in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Rye Grass at all — not against nitisinone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rye Grass safety at a glance

Rye Grass overall Use caution Generally well tolerated in studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining nitisinone and Rye Grass? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Rye Grass Itself Has Been Linked To

This is not an interaction — nothing below involves nitisinone. It is the side-effect record for Rye Grass on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Rye Grass, this list is the first place to look.

  • Heartburn / Nausea Additional detail

    “Orally, rye grass pollen extract can cause abdominal distention, heartburn, and nausea.”

    Rye Grass · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 5293. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433-8.

Everything above comes from the Natural Medicines adverse-effect record for Rye Grass — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of nitisinone’s FDA label too, and the two lists don’t meaningfully overlap — which is why no nitisinone column appears here.

Everything else you take

See Every Supplement That Interacts With nitisinone

This page covers Rye Grass only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the nitisinone page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cannabinol (cbn) (moderate), Cannabis (moderate), Coffee Charcoal (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the nitisinone page

“For a child or adult with hereditary tyrosinemia type 1, nitisinone (Orfadin, Nityr) is the medication holding a dangerous metabolic disease in check, which is why the 21 supplements on this page warrant genuine care rather than a shrug. Activated charcoal is the single major-rated entry and the one to understand first, since it can so…”

Reviewed by 2 · Jul 18, 2026

Open the nitisinone interaction page

How much people look this up

Where Rye Grass and nitisinone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rye Grass
Steady interest

#994 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication nitisinone
Top half

#1,325 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rye Grass reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rye Grass and nitisinone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rye Grass

What is Rye Grass?

  • Prostate symptoms (BPH)
  • Chronic prostatitis
  • Urinary symptoms
  • General wellness/nutrition
  • Allergy desensitization (research only)

Rye grass pollen extract is most often used as a supplement for prostate-related urinary symptoms, where some small studies suggest a possible benefit, but the overall evidence is limited and not conclusive. It is generally well tolerated, but it is not a proven treatment, and you should talk to your doctor or pharmacist before using it, especially if you have prostate or urinary problems.

Secale cereale · Poaceae · Pollen extract, grass (leaves), and seeds/grain · Tablets, capsules, pollen extracts, and dried grass powders

An interaction check asks whether these two react with each other — it does not ask whether Rye Grass is a good idea for someone in your situation. Here is what our Rye Grass record says about it on its own.

Rye Grass: dosing

There is no official or standardized dose for rye grass pollen extract. They can help you decide whether it is appropriate for you and review it alongside your other medicines and conditions.

From our Rye Grass monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rye Grass monograph & all interactions
Medication

About Nitisinone

What Is Nitisinone Used For?

Brand names: Orfadin, Nityr

Nitisinone (as Orfadin capsules, Orfadin oral suspension, Nityr tablets, and generic Nitisinone capsules) is used to treat hereditary tyrosinemia type 1 (HT-1) — a rare inherited disease in which the body cannot properly break down the amino acid tyrosine, leading to toxic buildup that damages the liver and kidneys. It is used in both adults and children, always together with a strict low-tyrosine, low-phenylalanine diet.

Harliku tablets are approved for a different rare inherited condition: alkaptonuria (AKU). In adults with AKU, Harliku reduces the level of homogentisic acid (HGA) — a harmful substance that builds up in the urine and body tissues. Harliku is not approved for HT-1, and the other nitisinone products are not approved for AKU.

Most-Reported Side Effects for nitisinone

From FAERS, the FDA’s public side-effect reporting system (948 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Amino acid level increased 133 reports
Liver transplant 118 reports
Hepatocellular carcinoma 61 reports
Alpha 1 foetoprotein increased 52 reports
Treatment noncompliance 51 reports
See full Nitisinone drug information
Keep checking

Other Drugs & Rye Grass

Browse every other medication we’ve checked against Rye Grass — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Rye Grass against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Rye Grass list.

See the full Rye Grass interactions page
See every supplement checked against nitisinone, ranked by severity
Evidence & sources

Rye Grass References

The 1 references that drive our Rye Grass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rye Grass and nitisinone Together: Common Questions

Is it safe to take Rye Grass with nitisinone?
We do not list a known interaction between Rye Grass and nitisinone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does nitisinone interact with any supplements?
Yes. nitisinone has documented interactions with 21 supplements in our database — Rye Grass is not one of them. The nitisinone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rye Grass monograph Uses, safety profile, and every drug interaction in one place Nitisinone drug information The full plain-English guide to this medication nitisinone supplement interactions Every supplement checked against nitisinone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About nitisinone and Rye Grass?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.