Drug & supplement interaction

S-23 + Paclitaxel

Paclitaxel brand names: Taxol, Abraxane.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between S-23 and Paclitaxel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

S-23 and Paclitaxel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paclitaxel and S-23 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for S-23 at all — not against Paclitaxel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

S-23 safety at a glance

S-23 overall Avoid S-23 is an unapproved experimental drug with no human safety data and known hormonal risks.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androge... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paclitaxel and S-23? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Paclitaxel’s Own FDA Label Lists

This is not an interaction — none of it involves S-23. These are the most notable effects listed in the ADVERSE REACTIONS section of Paclitaxel’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 5.5% of FDA reports for Paclitaxel

From the ADVERSE REACTIONS section of the FDA label for Paclitaxel. Read the label on DailyMed › Where a percentage is shown, it is the share of 98,465 voluntary FDA FAERS reports for Paclitaxel that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. S-23’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no S-23 side to compare — that is a limit of the record, not a statement that S-23 has no side effects.

Special populations

S-23 in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing selective androgen receptor modulators (SARMs) are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Paclitaxel Is Prescribed For, and What S-23 Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Paclitaxel is a prescription medicine with approved uses on its FDA label. S-23 is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Paclitaxel is prescribed for: Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is used to treat three types of cancer. It treats metastatic breast cancer in patients whose prior chemotherapy has stopped working or who relapsed within 6 months of completing adjuvant (post-surgery) chemotherapy. It is also used as a first-line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC) — given together with carboplatin — in patients who cannot have surgery or radiation therapy. Additionally, it is approved as a first-line treatment for metastatic adenocarcinoma of the pancreas, given in combination with gemcitabine.

Read the rest of what Paclitaxel is prescribed for

All three uses apply specifically to Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound), including the brands Abraxane and related albumin-bound formulations.

S-23 has been studied for:

  • Breast cancer studied, not established S-23 has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    S-23 for breast cancer

    Although there is interest in using oral S-23 for breast cancer, there is insufficient reliable information about the clinical effects of S-23 for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Paclitaxel on your own; if you are taking S-23 for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Paclitaxel

This page covers S-23 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paclitaxel page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Grapefruit (major), St. John's Wort (major) and Sweet Orange (major).

By severity: 5 major · 108 moderate · 39 minor.

Open the Paclitaxel interaction page

One more smart check

Taking S-23 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing S-23, each one broken down to its full ingredient list — and combination products often carry several ingredients besides S-23. Even though S-23 itself has no known interaction with Paclitaxel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where S-23 and Paclitaxel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement S-23
Steady interest

#955 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paclitaxel
Steady interest

#1,788 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every S-23 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The S-23 and Paclitaxel records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About S-23

What is S-23?

  • Muscle building
  • Fat loss
  • Athletic performance enhancement
  • Body recomposition
  • Investigational male contraceptive (research only)

S-23 is an experimental, non-prescription synthetic drug called a selective androgen receptor modulator (SARM), not a dietary supplement, herb, or natural product. It has never been approved for human use, has not been proven safe in people, and is banned in sports; we do not recommend using it.

Not applicable; S-23 is a synthetic chemical compound · Liquid solutions, capsules, and powders sold as 'research chemicals'

An interaction check asks whether these two react with each other — it does not ask whether S-23 is a good idea for someone in your situation. Here is what our S-23 record says about it on its own.

S-23: dosing

There is no established or safe dose of S-23 for humans. It has never gone through the clinical testing that would set a safe and effective dose, so any amounts shared online are unverified and potentially dangerous.We do not provide dosing guidance for S-23 because doing so could imply it is safe to use, which it is not.

From our S-23 monograph — the full record covers uses, side effects and every documented interaction.

Read the full S-23 monograph & all interactions
Medication

About Paclitaxel (with albumin) Injection

What Is Paclitaxel (with albumin) Injection Used For?

Brand names: Taxol, Abraxane

Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is used to treat three types of cancer. It treats metastatic breast cancer in patients whose prior chemotherapy has stopped working or who relapsed within 6 months of completing adjuvant (post-surgery) chemotherapy. It is also used as a first-line treatment for locally advanced or metastatic non-small cell lung cancer (NSCLC) — given together with carboplatin — in patients who cannot have surgery or radiation therapy.

Additionally, it is approved as a first-line treatment for metastatic adenocarcinoma of the pancreas, given in combination with gemcitabine. All three uses apply specifically to Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound), including the brands Abraxane and related albumin-bound formulations.

Most-Reported Side Effects for Paclitaxel

From FAERS, the FDA’s public side-effect reporting system (98,465 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 5,500 reports
Neutropenia 5,424 reports
Diarrhea 5,152 reports
Dyspnea 5,113 reports
Anemia 4,794 reports
See full Paclitaxel (with albumin) Injection drug information
Keep checking

Other Drugs & S-23

Browse every other medication we’ve checked against S-23 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked S-23 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full S-23 list.

See the full S-23 interactions page
See every supplement checked against Paclitaxel, ranked by severity
Evidence & sources

S-23 References

The 1 references that drive our S-23 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking S-23 and Paclitaxel Together: Common Questions

Is it safe to take S-23 with Paclitaxel?
We do not list a known interaction between S-23 and Paclitaxel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are S-23 and Paclitaxel used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for S-23 in each. That is a conversation for your prescriber, especially if Paclitaxel is being adjusted to a target.
Does Paclitaxel interact with any supplements?
Yes. Paclitaxel has documented interactions with 152 supplements in our database — S-23 is not one of them. The Paclitaxel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

S-23 monograph Uses, safety profile, and every drug interaction in one place Paclitaxel (with albumin) Injection drug information The full plain-English guide to this medication Paclitaxel supplement interactions Every supplement checked against Paclitaxel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paclitaxel and S-23?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.