Drug & supplement interaction

Sarsaparilla + Glasdegib

Glasdegib brand name: Daurismo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sarsaparilla and Glasdegib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sarsaparilla and Glasdegib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glasdegib and Sarsaparilla in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sarsaparilla safety at a glance

Sarsaparilla overall Use caution Likely low-risk in food amounts, but human safety data for supplement doses are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glasdegib and Sarsaparilla? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glasdegib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glasdegib is filed under 3 classifications — qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Sarsaparilla has documented interactions with 2 drug classes — the most serious being digoxin (lanoxin) (moderate) and lithium (moderate) — and none of Glasdegib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sarsaparilla Does Interact With Other Medications

Sarsaparilla has 2 moderate known drug interactions in our database — Glasdegib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Glasdegib)
Taking anything else?

Check Another of Your Medications Against Sarsaparilla

Covers the 2,830 medications we’ve checked against Sarsaparilla. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sarsaparilla and Glasdegib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    Sarsaparilla

    “Occupational exposure to sarsaparilla root dust can cause rhinitis and asthma symptoms.”

    Sarsaparilla · Natural Medicines adverse-effect record, reported in asthma.

    1 source cited
    1. 4111. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

    Glasdegib

    Listed in the ADVERSE REACTIONS section of the FDA label for Glasdegib. Read the label on DailyMed ›

Reported for Sarsaparilla but not commonly for Glasdegib: a stuffy or runny nose.

Effects for Glasdegib come from the ADVERSE REACTIONS section of its FDA label; effects for Sarsaparilla come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Glasdegib Is Prescribed For, and What Sarsaparilla Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Glasdegib is a prescription medicine with approved uses on its FDA label. Sarsaparilla is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Glasdegib is prescribed for: Daurismo (glasdegib) is approved to treat newly-diagnosed acute myeloid leukemia (AML) — a fast-growing cancer of the blood and bone marrow. It is used specifically in adults who are 75 years of age or older, or in adults of any age whose other health conditions make intensive induction chemotherapy too risky. Daurismo is not used alone. It is always given together with low-dose cytarabine, a separate chemotherapy medicine, as part of a 28-day treatment cycle.

Sarsaparilla has been studied for:

  • Cancer studied, not established Sarsaparilla has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Sarsaparilla for cancer

    Although there has been interest in using oral sarsaparilla for cancer, there is insufficient reliable information about the clinical effects of sarsaparilla for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Glasdegib on your own; if you are taking Sarsaparilla for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Glasdegib

This page covers Sarsaparilla only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glasdegib page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 98 moderate · 40 minor.

From our pharmacist’s overview on the Glasdegib page

“Grapefruit is the first thing I would take off the table for anyone on glasdegib (Daurismo), a targeted pill for acute myeloid leukemia. It can push glasdegib levels up because the drug is cleared by the CYP3A4 enzyme, and 121 of the 146 ingredients touch that pathway, some raising its level and others, like St.”

Reviewed by 2 · Jul 18, 2026

Open the Glasdegib interaction page

One more smart check

Taking Sarsaparilla as Part of a Dietary Supplement Product? Check It for Interactions

We hold 171 real supplement products containing Sarsaparilla, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sarsaparilla. Even though Sarsaparilla itself has no known interaction with Glasdegib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sarsaparilla and Glasdegib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sarsaparilla
Top 25%

#253 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glasdegib
Steady interest

#2,227 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sarsaparilla reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sarsaparilla and Glasdegib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sarsaparilla

What is Sarsaparilla?

  • Skin conditions like psoriasis
  • Joint pain and arthritis
  • General tonic or 'blood purifier'
  • Boosting athletic performance
  • Flavoring in beverages

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it should not replace proven treatments. It is generally considered low-risk for short-term use, but pregnant and breastfeeding people should avoid it due to a lack of safety data.

Smilax spp. · Smilacaceae · Dried root and rhizome · Capsules, tablets, dried root, tea, liquid extract, tincture

An interaction check asks whether these two react with each other — it does not ask whether Sarsaparilla is a good idea for someone in your situation. Here is what our Sarsaparilla record says about it on its own.

Sarsaparilla: dosing

There is no well-established standard dose for sarsaparilla. Products vary widely in strength and how they are prepared, so the amount in one capsule or tea may be very different from another.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Sarsaparilla monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sarsaparilla monograph & all interactions
Medication

About Glasdegib

What Is Glasdegib Used For?

Brand name: Daurismo

Daurismo (glasdegib) is approved to treat newly-diagnosed acute myeloid leukemia (AML) — a fast-growing cancer of the blood and bone marrow. It is used specifically in adults who are 75 years of age or older, or in adults of any age whose other health conditions make intensive induction chemotherapy too risky.

Daurismo is not used alone. It is always given together with low-dose cytarabine, a separate chemotherapy medicine, as part of a 28-day treatment cycle.

See full Glasdegib drug information
Keep checking

Other Drugs & Sarsaparilla

Browse every other medication we’ve checked against Sarsaparilla — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Sarsaparilla against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Sarsaparilla list.

See the full Sarsaparilla interactions page
See every supplement checked against Glasdegib, ranked by severity
Evidence & sources

Sarsaparilla References

The 3 references that drive our Sarsaparilla monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sarsaparilla and Glasdegib Together: Common Questions

Is it safe to take Sarsaparilla with Glasdegib?
We do not list a known interaction between Sarsaparilla and Glasdegib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sarsaparilla and Glasdegib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Sarsaparilla and Glasdegib used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sarsaparilla in each. That is a conversation for your prescriber, especially if Glasdegib is being adjusted to a target.
How was the Sarsaparilla and Glasdegib combination checked?
Interactions in our licensed database are recorded against drug classes. Glasdegib is filed under 3 classifications, and Sarsaparilla has documented interactions with 2 drug classes — none of Glasdegib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Sarsaparilla interact with any other medications?
Yes. Sarsaparilla has 2 documented drug interactions in our database — Glasdegib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glasdegib interact with any supplements?
Yes. Glasdegib has documented interactions with 146 supplements in our database — Sarsaparilla is not one of them. The Glasdegib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sarsaparilla monograph Uses, safety profile, and every drug interaction in one place Glasdegib drug information The full plain-English guide to this medication Glasdegib supplement interactions Every supplement checked against Glasdegib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glasdegib and Sarsaparilla?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.