Shiatsu + Daprodustat
Daprodustat brand name: Jesduvroq.
We found no known interaction between Shiatsu and Daprodustat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Shiatsu and Daprodustat
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Daprodustat and Shiatsu in our sources. This does not guarantee that the combination is completely free of risk — research on Shiatsu alongside specific medications may be limited.
Worth understanding: our licensed dataset holds no drug-interaction record for Shiatsu at all — not against Daprodustat, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
Shiatsu is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Shiatsu safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Shiatsu in Pregnancy & Breastfeeding
When used appropriately. Shiatsu massage has been safely received by those who are pregnant without reports of serious adverse effects.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Daprodustat Is Prescribed For, and What Shiatsu Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Daprodustat is a prescription medicine with approved uses on its FDA label. Shiatsu is a treatment: what follows is what researchers have looked at it for, and how strong that evidence is.
Daprodustat is prescribed for: Jesduvroq (daprodustat) is approved to treat anemia due to chronic kidney disease (CKD) in adults who have been on dialysis for at least four months. It works by stimulating the body's own red blood cell production to reduce the need for blood transfusions. Important limits: Jesduvroq is not a substitute for emergency blood transfusions, and it is not approved for people with CKD who are not on dialysis. It has also not been shown to improve quality of life, fatigue, or overall well-being.
Shiatsu has been studied for:
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Quality of life studied, not established Shiatsu has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Shiatsu for quality of life
One small clinical study shows that shiatsu therapy once weekly for 5 weeks improves energy, stress, confidence, mobility, and other measures of quality of life in patients with advanced progressive disease receiving palliative care when compared to baseline. The validity of these findings is limited by the lack of a comparator group.
1 source cited
- 89100. Cheesman, S., Christian, R., and Cresswell, J. Exploring the value of shiatsu in palliative care day services. Int J Palliat Nurs 2001;7(5):234-239. PubMed
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Daprodustat on your own; if you are taking Shiatsu for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Daprodustat
This page covers Shiatsu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Daprodustat page lists 28 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), African Wild Potato (moderate), Breadfruit (moderate), Cannabidiol (cbd) (moderate) and Coffee Charcoal (moderate).
By severity: 1 major · 16 moderate · 11 minor.
From our pharmacist’s overview on the Daprodustat page
“People taking daprodustat (Jesduvroq) for anemia from chronic kidney disease are often the same people using fiber for constipation or CBD for sleep, and this interaction list deserves genuine care. Of the 28 supplement ingredients on file, eleven may block CYP2C8, the enzyme that clears daprodustat, which could raise its levels beyond…”
Reviewed by 2 · Jul 18, 2026
Where Shiatsu and Daprodustat Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,245 of 1,452 supplements looked up here in the last 7 days
#2,348 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Shiatsu reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Shiatsu and Daprodustat records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Shiatsu
What is Shiatsu?
- Stress and relaxation
- Muscle tension and stiffness
- Low back and neck pain
- Headaches
- General well-being
- Sleep problems
Shiatsu is a Japanese form of massage and bodywork, not a herb or dietary supplement, so it is not something you swallow. Many people find it relaxing and helpful for stress and muscle tension, but high-quality research on its health benefits is limited. It is generally low-risk for most people when done by a trained practitioner, but talk with your doctor first if you have a medical condition.
Not applicable — Shiatsu is a hands-on therapy, not a plant or supplement · In-person bodywork sessions performed by a trained practitioner
An interaction check asks whether these two react with each other — it does not ask whether Shiatsu is a good idea for someone in your situation. Here is what our Shiatsu record says about it on its own.
Shiatsu: dosing
Because Shiatsu is a hands-on therapy and not something you swallow, there is no dose in milligrams or pills. Sessions usually last around 30 to 60 minutes, and how often people go varies widely based on their goals and comfort.There is no standard "prescription" for how many sessions are needed. If you want to try Shiatsu, choose a qualified practitioner, start slowly, and discuss your health history with them.
From our Shiatsu monograph — the full record covers uses, side effects and every documented interaction.
About Daprodustat
What Is Daprodustat Used For?
Brand name: Jesduvroq
Jesduvroq (daprodustat) is approved to treat anemia due to chronic kidney disease (CKD) in adults who have been on dialysis for at least four months. It works by stimulating the body's own red blood cell production to reduce the need for blood transfusions.
Important limits: Jesduvroq is not a substitute for emergency blood transfusions, and it is not approved for people with CKD who are not on dialysis. It has also not been shown to improve quality of life, fatigue, or overall well-being.
Most-Reported Side Effects for Daprodustat
From FAERS, the FDA’s public side-effect reporting system (1,878 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Shiatsu
Browse every other medication we’ve checked against Shiatsu — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Shiatsu against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Escitalopram ›
- Rivaroxaban ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Methamphetamine ›
- Tadalafil ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Isotretinoin ›
- Lisinopril ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Amphetamine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Codeine ›
- Naproxen ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Shiatsu list.
Shiatsu References
The 16 references that drive our Shiatsu monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Iwanami H, Odaka M, Hirata K. [Bilateral cerebellar infarction caused by intracranial dissection of the vertebral artery after long periods of "Shiatsu"] . Brain Nerve 2007;59:169-71.
- Saito, H. Preventing and resolving post-laparotomy intestinal obstruction: an effective shiatsu method. Am J Chin Med 2000;28(1):141-145. PubMed
- Ingram, J., Domagala, C., and Yates, S. The effects of shiatsu on post-term pregnancy. Complement Ther Med 2005;13(1):11-15. PubMed
- Brady, L. H., Henry, K., Luth, J. F. 2nd, and Casper-Bruett, K. K. The effects of shiatsu on lower back pain. J Holist Nurs 2001;19(1):57-70. PubMed
- Cheesman, S., Christian, R., and Cresswell, J. Exploring the value of shiatsu in palliative care day services. Int J Palliat Nurs 2001;7(5):234-239. PubMed
- Brown CA, Bostick G, Bellmore L, Kumanayaka D. Hand self-Shiatsu for sleep problems in persons with chronic pain: a pilot study. J Integr Med 2014;12(2):94-101. PubMed
- Herskovitz S, Strauch B, Gordon MJ. Shiatsu massage-induced injury of the median recurrent motor branch. Muscle Nerve 1992;15(10):1215.
- Lichtenberg P, Vass A, Ptaya H, Edelman S, Heresco-Levy U. Shiatsu as an adjuvant therapy for schizophrenia: an open-label pilot study. Altern Ther Health Med 2009;15(5):44-6.
- Mumm AH, Morens DM, Elm JL, Diwan AR. Zoster after shiatsu massage. Lancet 1993;341(8842):447. PubMed
- Teimoori B, Rajabi S, Navvabi-Rigi SD, Arbabisarjou A. Evaluation effect of shiatsu technique on labor induction in post-term pregnancy. Glob J Health Sci 2014;7(3):177-83. PubMed
- Wada Y, Yanagihara C, Nishimura Y. Internal jugular vein thrombosis associated with shiatsu massage of the neck. J Neurol Neurosurg Psychiatry 2005;76(1):142-3. PubMed
- Yeh CC, Ko SC, Huh BK, et al. Shoulder tip pain after laparoscopic surgery analgesia by collateral meridian acupressure (shiatsu) therapy: a report of 2 cases. J Manipulative Physiol Ther. 2008;31(6):484-8. PubMed
- Tsuboi K, Tsuboi K. Retinal and cerebral artery embolism after "shiatsu" on the neck. Stroke 2001;32(10):2441. DOI
- Lanza G, Centonze SS, Destro G, et al. Shiatsu as an adjuvant therapy for depression in patients with Alzheimer's disease: A pilot study. Complement Ther Med. 2018;38:74-78. PubMed
- Kobayashi D, Shimbo T, Hayashi H, Takahashi O. Shiatsu for chronic lower back pain: Randomized controlled study. Complement Ther Med 2019;45:33-37. PubMed
- Harorani M, Garshasbi M, Sediqi M, et al. The effect of Shiatsu massage on agitation in mechanically ventilated patients: A randomized controlled trial. Heart Lung 2021;50(6):893-897. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Having Shiatsu While Taking Daprodustat: Common Questions
Is it safe to have Shiatsu while taking Daprodustat?
Do Shiatsu and Daprodustat have any of the same side effects?
Are Shiatsu and Daprodustat used for the same thing?
Does Daprodustat interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.