Drug & supplement interaction

Simaruba + Obinutuzumab

Obinutuzumab brand name: Gazyva.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Simaruba and Obinutuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Obinutuzumab states a food rule worth keeping to.

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Interaction report

Simaruba and Obinutuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Obinutuzumab and Simaruba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Simaruba at all — not against Obinutuzumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Simaruba safety at a glance

Simaruba overall Use caution Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Likely Unsafe When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of s... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of s... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Obinutuzumab and Simaruba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Simaruba Itself Has Been Linked To

This is not an interaction — nothing below involves Obinutuzumab. It is the side-effect record for Simaruba on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Simaruba, this list is the first place to look.

  • Vomiting Additional detail

    “Orally, ingesting large amounts of simaruba can cause vomiting (18).”

    Simaruba · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Simaruba — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Obinutuzumab’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Obinutuzumab column appears here.

Special populations

Simaruba in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally during pregnancy due to apparent abortifacient effects; avoid using. There is insufficient reliable information available about the safety of simaruba during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Obinutuzumab Products Have a Food Rule — Simaruba Should Not Break It

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach. Most supplements — Simaruba included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Obinutuzumab on its own and move Simaruba to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Obinutuzumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

650–1,000 mg acetaminophen At least 30 minutes before GAZYVA infusion.

From the Dosage and Administration section of the FDA label we read for Obinutuzumab — where that label names a specific product, the instruction is that product's. See the Obinutuzumab drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

One more smart check

Taking Simaruba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Simaruba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Simaruba. Even though Simaruba itself has no known interaction with Obinutuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Simaruba and Obinutuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Simaruba
Top half

#614 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Obinutuzumab
Steady interest

#2,267 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Simaruba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Simaruba and Obinutuzumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Simaruba

What is Simaruba?

  • Diarrhea and dysentery
  • Digestive upset
  • Malaria and fevers (traditional)
  • Intestinal parasites
  • General antimicrobial use

Simaruba (Simarouba amara) is a tropical tree whose bark has long been used in folk medicine for diarrhea, dysentery, and fevers. Modern, high-quality human studies are very limited, so its benefits and safety are not well proven. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Simarouba amara · Simaroubaceae · Bark (especially root and stem bark), sometimes leaves · Dried bark for tea or decoction, tincture, capsules, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Simaruba is a good idea for someone in your situation. Here is what our Simaruba record says about it on its own.

Simaruba: dosing

There is no standardized, well-established dose for Simaruba. Traditional preparations were usually water-based extracts (decoctions) of the bark, but these vary widely in strength.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Simaruba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Simaruba monograph & all interactions
Medication

About Obinutuzumab Injection

What Is Obinutuzumab Injection Used For?

Brand name: Gazyva

Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy.

Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

See full Obinutuzumab Injection drug information
Keep checking

Other Drugs & Simaruba

Browse every other medication we’ve checked against Simaruba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Simaruba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Simaruba list.

See the full Simaruba interactions page
See every supplement checked against Obinutuzumab, ranked by severity
Evidence & sources

Simaruba References

The 2 references that drive our Simaruba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Hocking GM. A dictionary of natural products. 2nd ed. Medford, OR: Plexus Publishing, 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Simaruba and Obinutuzumab Together: Common Questions

Is it safe to take Simaruba with Obinutuzumab?
We do not list a known interaction between Simaruba and Obinutuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Simaruba and Obinutuzumab at the same time of day?
At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Obinutuzumab on its own and move Simaruba to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Simaruba monograph Uses, safety profile, and every drug interaction in one place Obinutuzumab Injection drug information The full plain-English guide to this medication Obinutuzumab supplement interactions Every supplement checked against Obinutuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Obinutuzumab and Simaruba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.