Spiny Restharrow + Telotristat Etiprate
Telotristat Etiprate brand name: Xermelo.
We found no known interaction between Spiny Restharrow and Telotristat Etiprate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Telotristat Etiprate states a food rule worth keeping to.
Spiny Restharrow and Telotristat Etiprate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Telotristat Etiprate and Spiny Restharrow in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Spiny Restharrow safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Telotristat Etiprate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Telotristat Etiprate is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) inducers, oral drugs. Spiny Restharrow has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Telotristat Etiprate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Spiny Restharrow Does Interact With Other Medications
Spiny Restharrow has 1 moderate known drug interaction in our database — Telotristat Etiprate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Spiny Restharrow
We haven’t checked that one against Spiny Restharrow yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Spiny Restharrow. Pick one to open its full report.
Some Telotristat Etiprate Products Have a Food Rule — Spiny Restharrow Should Not Break It
At least one FDA label for a product containing Telotristat Etiprate says to take it with food. If you take Spiny Restharrow on an empty stomach out of habit, keep them separate — and take Telotristat Etiprate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Telotristat Etiprate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administration Take Xermelo with food [see Clinical Pharmacology ( 12.3 ), Clinical Studies ( 14 )] .
From the Dosage and Administration section of the FDA label we read for Telotristat Etiprate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Telotristat Etiprate
This page covers Spiny Restharrow only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Telotristat Etiprate page lists 36 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Boneset (moderate) and Borage (moderate).
By severity: 1 major · 26 moderate · 9 minor.
From our pharmacist’s overview on the Telotristat Etiprate page
“Telotristat etiprate (Xermelo) works in the gut to calm the severe diarrhea of carcinoid syndrome, and the lone major-rated interaction among its 36 flagged supplements strikes at that point. Activated charcoal can soak up the drug before it reaches the bloodstream, and 17 of the entries, mostly bulking fibers and charcoal products, ca…”
Reviewed by 2 · Jul 18, 2026
Taking Spiny Restharrow as Part of a Dietary Supplement Product? Check It for Interactions
We hold 17 real supplement products containing Spiny Restharrow, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Spiny Restharrow. Even though Spiny Restharrow itself has no known interaction with Telotristat Etiprate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Spiny Restharrow and Telotristat Etiprate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#909 of 1,452 supplements looked up here in the last 7 days
#2,214 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Spiny Restharrow reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Spiny Restharrow and Telotristat Etiprate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Spiny Restharrow
What is Spiny Restharrow?
- Increasing urine flow (mild diuretic)
- Flushing the urinary tract
- Mild bladder and kidney complaints
- Fluid retention
- Traditional support for skin and joint complaints
Spiny Restharrow is a traditional European herb whose root has long been used as a mild diuretic to help flush the urinary tract. Solid human evidence for its benefits is very limited, so any effect remains unproven. If you want to try it, talk with a pharmacist or doctor first, especially if you have kidney, heart, or fluid-balance concerns.
Ononis spinosa · Fabaceae · Root (and sometimes the aerial/flowering parts) · Tea (dried root), tinctures, liquid extracts, capsules
An interaction check asks whether these two react with each other — it does not ask whether Spiny Restharrow is a good idea for someone in your situation. Here is what our Spiny Restharrow record says about it on its own.
Spiny Restharrow: dosing
There is no well-established standardized dose for Spiny Restharrow. Traditional use mainly involves a tea made from the dried root, but exact amounts vary widely between products and references.The safest approach is to follow the directions on the product label and not exceed them.
From our Spiny Restharrow monograph — the full record covers uses, side effects and every documented interaction.
About Telotristat
What Is Telotristat Used For?
Brand name: Xermelo
Xermelo (telotristat) tablets are approved to treat carcinoid syndrome diarrhea in adults. Carcinoid syndrome is a set of symptoms caused by certain tumors — called neuroendocrine tumors — that release excess serotonin into the body, triggering frequent, often severe diarrhea.
Xermelo is used in combination with somatostatin analog (SSA) therapy — a class of injected medications commonly used to control carcinoid syndrome — in patients whose diarrhea is still not adequately controlled by SSA therapy alone.
Other Drugs & Spiny Restharrow
Browse every other medication we’ve checked against Spiny Restharrow — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Spiny Restharrow against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Spiny Restharrow list.
Spiny Restharrow References
The 2 references that drive our Spiny Restharrow monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Spiny Restharrow and Telotristat Etiprate Together: Common Questions
Is it safe to take Spiny Restharrow with Telotristat Etiprate?
Should I take Spiny Restharrow and Telotristat Etiprate at the same time of day?
How was the Spiny Restharrow and Telotristat Etiprate combination checked?
Does Spiny Restharrow interact with any other medications?
Does Telotristat Etiprate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.